Antiviral drug resistance is one of the most common problems in medicine, and, therefore, finding new antiviral agents, especially from natural resources, seems to be necessary. This study was designed assay activity curcumin and its derivatives like gallium-curcumin Cu-curcumin on replication HSV-1 cell culture. The research performed as an vitro which different concentrations three substances including curcumin, Gallium-curcumin were tested HSV-1. cytotoxicity compounds also evaluated Vero...

Gracilaria corticata is a red alga which can be collected from many sea coasts around the world such as China, India, Persian Gulf, etc. The Gulf unique marine habitat infested with diverse seaweeds. aim of present study to explore anticancer potential crude extracts G. was Bushehr coast (South west Iran). Here, different concentration aqueous extract tested for probable antitumoral activity on Jurkat and molt4 human lymphoblastic leukemic cell lines. cells were treated by algal number...

Abstract Background The emergence of fluoroquinolone resistance in clinical isolates Klebsiella pneumoniae is a growing concern. To investigate the mechanisms behind this resistance, we studied total 215 K. from hospitals Bushehr province, Iran, collected between 2017 and 2019. Antimicrobial susceptibility test for fluoroquinolones was determined. presence plasmid mediated quinolone (PMQR) mutations resistance-determining region (QRDR) gyrA parC genes ciprofloxacin-resistant were identified...

This study was conducted at a 900+ bed general teaching hospital, from May to September 2007, in Iran. The aim of this determine the prevalence extended-spectrum beta-lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae their antimicrobial pattern. Kirby-Bauer disk diffusion method phenotypic confirmatory test were performed for each isolate. total 206 isolates including 106 E. 100 K. collected which 122 (59.2%) ESBL positive. ESBL-producing strains 59.2% (122/206). All...

Tumor-targeted superantigens (TTSs) have been used to treat a variety of tumors in preclinical studies. The TTS utilizes the powerful T-cell activation strategy by means staphylococcal enterotoxins (SEs) as (Sags) target tumor cells. Monoclonal antibodies and tumor-related ligands targeting molecules Sag. In this study, we assessed antitumor potency tumor-targeted superantigen (TTS) design produce fusion protein new candidate. third loop (L3) transforming growth factor α (TGF-α) was...

Increasing the rate of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae has given rise to a major healthcare issue in clinical settings over past few years. Treatment these strains is hardly effective since plasmid encoding ESBL may also carry other resistance genes including aminoglycosides. The current study aimed evaluate prevalence ESBL-producing K. and investigate coexistence Cefoxitamase-Munich (blaCTX-M) with aminoglycoside-modifying enzyme (AME) genes, aac(3)IIa...

Abstract Food fraud and profiteering are becoming increasingly common in the meat industry. Therefore, it is essential to identify such practices prevent consumer deception maintain food safety. This study aimed determine contents of minced samples labeled as beef mutton retail stores across Tehran province, Iran, instances adulteration. To this end, randomly collected 300 from over 4 years (2018–2022) analyzed them using duplex polymerase chain reaction (PCR). The results revealed that more...

Recent research has attempted to direct superantigens towards tumors by means of tumor-targeted superantigen (TTS) strategy. In this study, we explored the antitumor property TTS fusing third loop transforming growth factor α (TGFαL3) staphylococcal enterotoxin type B (SEB) and investigated possibility therapeutic application TGFαL3-SEB as a novel candidate in mice bearing breast cancer. Treatment was performed through intratumoral intravenous injection TGFαL3-SEB. Tumor size/volume,...

Tuberculosis is a well-known infectious disease in human beings and domestic animals since ancient times. Tuberculin skin test as the only indicator of latent infection with Mycobacterium tuberculosis has low specificity sensitivity value. This also cannot distinguish between bovis BCG vaccination, or exposure to environmental mycobacteria. Recent identification RD1 region M. provides new opportunity for development novel diagnostic tools. The purpose this study was clone express 10-kda...

Production of metallo-β-lactamases (MBLs) is an important mechanism resistance to carbapenems. This study aimed detect the MBL-producing Pseudomonas aeruginosa clinical isolates and investigate presence blaVIM, blaIMP, blaSPM, blaNDM, blaGIM, blaAIM, blaSIM genes in these Bushehr, Iran.A total 169 P. were collected from three hospitals Bushehr. The modified carbapenem inactivation method (mCIM) was used for phenotypic detection carbapenemase production. A combination disk test (CDT)...

Background and Objectives: Klebsiella pneumoniae is an opportunistic pathogen responsible for causing nosocomial community-acquired infections. Its pathogenicity associated with a variety of virulence factors antibiotic resistance. The aim the present study was to compare attributes between ESBL non-ESBL producing isolates. Materials Methods: A total 113 K. including 56 57 non ESBL-producers were collected in Bushehr province, Iran, from November 2017 February 2019. Enzymatic profile,...

Coronavirus disease 2019 (COVID-19) is a new medical challenge for all individuals, especially those with underlying disorders, such as congenital bleeding disorders (CBDs). Therefore, the pandemic might significantly change behaviour of patients CBDs and results in some challenges. In present study, we assessed main challenges COVID-19 infection to CBDs. Data were collected from files interviews who had infection. Follow-ups performed on active severe acute respiratory syndrome coronavirus...

The development of the thymus is linked to that parathyroid glands, which are small endocrine glands in neck and produce hormone responsible for calcium homeostasis (1). a lymphoepithelial organ derived embryologically from third fourth pharyngeal pouches, descend anterior mediastinum by sixth week gestation (2). Because dorsal wing pouch with thymus, an ectopic thymus-parathyroid complex, mechanistically suggests aberrant migration (3). Inthis paper, we report these rare concomitant events...