A5079171500- Pluripotent Stem Cells Research
- Parkinson's Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- RNA Research and Splicing
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Biochemical effects in animals
- Microbial Metabolites in Food Biotechnology
- Immune Response and Inflammation
- Sirtuins and Resveratrol in Medicine
- Neurological Disease Mechanisms and Treatments
- Plant nutrient uptake and metabolism
- Nuclear Receptors and Signaling
China Medical University Hospital
2016-2025
China Medical University
2016-2025
Southern Medical University
2024
Nanfang Hospital
2024
Asia University
2015-2021
Institute of Immunology
2002-2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2016
Institute of Molecular Biology, Academia Sinica
2007
National Taiwan University
2003-2005
Two novel yeast splicing factors required for spliceosome disassembly have been identified. Ntr1 and Ntr2 (NineTeen complex-Related proteins) were identified their weak association with components of the Prp19-associated complex. Unlike other components, these two proteins primarily associated intron-containing during reaction. Extracts depleted or exhibited full activity, but accumulated large amounts lariat-intron in after splicing, indicating that normal function complex activation was...
Background Parkinson's disease (PD) is the second most common degenerative disorder of central nervous system that impairs motor skills and cognitive function. To date, has no effective therapies. The identification new drugs provide benefit in arresting decline seen PD patients focus much recent study. However, lengthy time frame for progression neurodegeneration increases both cost examining potential therapeutic compounds mammalian models. An alternative to first evaluate efficacy...
It is extremely challenging to achieve strong adhesion in soft tissues while minimizing toxicity, tissue damage, and other side effects caused by wound sealing materials. In this study, flexible synthetic hydrogel sealants were prepared based on polyethylene glycol (PEG) PEG a material that nontoxic inert and, thus, suitable for use medical products. We evaluated the vitro biocompatibility tests of dressings assess cytotoxicity irritation, sensitization, pyrogen systemic toxicity following...
The Saccharomyces cerevisiae splicing factors Ntr1 (also known as Spp382) and Ntr2 form a stable complex can further associate with DExD/H-box RNA helicase Prp43 to functional complex, termed the NTR which catalyzes spliceosome disassembly.We show that interacts Ntr1-Ntr2 in dynamic manner.The also bind first, before recruiting catalyze disassembly.Binding of or does not require ATP, but disassembly requires hydrolysis ATP.The dynamically U5 snRNP.Ntr2 component Brr2 is essential for both...
The movement disorder Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease, and associated with aging, environment, genetic factors. intracellular aggregation of α-synuclein loss dopaminergic neurons in substantia nigra pars compacta are pathological hallmark PD. At present, there no successful treatment for Maackiain (MK) a flavonoid extracted from dried roots Sophora flavescens Aiton. MK has emerged as novel agent PD that acts by inhibiting monoamine...
Epidermal growth factor receptor (EGFR), a critical promotes lung cancer cell proliferation and survival. Knockdown of EGFR expression thus promise beating clinically. Functionalized gold nanoparticles may serve an effective vehicle carrying theranostic bio-active materials. Herein, physically were fabricated with biocompatible collagen to improve siRNA loading capacity treat cancer. Physic-chemical properties comprehensively characterized for the nanoparticle (C–Au), conjugation,...
Microtubule-actin cross-linking factor 1 (MACF1), also known as actin family protein 7 (ACF7), is a giant cytolinker with multiple conserved domains that can orchestrate cytoskeletal networks of and microtubules. MACF1 involved in various biological processes, including cell polarity, cell–cell connection, proliferation, migration, vesicle transport, signal transduction, neuronal development. In this review, we updated the physiological pathological roles MACF1, highlighting components...
Carnosic acid (CA), a diterpene found in the rosemary (Rosmarinus officinalis), has been reported to have neuroprotective effect. Glutathione S-transferase (GST) P (GSTP) is phase II detoxifying enzyme that provides The aim of this study was explore whether effect CA via an upregulation GSTP expression and possible signaling pathways involved. SH-SY5Y cells were pretreated with 1 μM followed by treatment 100 6-hydroxydopamine (6-OHDA). Both immunoblotting activity results show also induced...
Parkinson's disease (PD) is the second most common degenerative disorder of central nervous system in elderly. It characterized by progressive loss dopaminergic neurons substantia nigra pars compacta, as well motor dysfunction. Although causes PD are not understood, aggregation α-synuclein (α-syn) contributes to this disease. Current therapeutics for provides satisfactory symptom relief but a cure. Treatment strategies include attempts identify new drugs that will prevent or arrest course...
Parkinson’s disease (PD) causes motor dysfunction and dopaminergic cell death. Drug treatments can effectively reduce symptoms but often cause unwanted side effects. Stem therapies using replacement or indirect beneficial secretomes have recently emerged as potential therapeutic strategies. Although various types of stem cells been proposed possible candidates, adipose-derived (ADSCs) are easily obtainable, more abundant, less ethically disputed, able to differentiate into multiple lineages....
Amyotrophic lateral sclerosis (ALS) is a fatal disease in which motor neurons gradually degenerate. The mutation of the C9orf72 gene main genetic cause ALS (C9-ALS). One its specific pathological features production proline-arginine (PR) dipeptide repeat protein (DPR). In this study, we developed PR-DPR (PR50)-expressing human HMC3 microglial cell model. We found that PR50 mainly aggregates into spots nucleus and induces significant NLRP3 inflammasome activity. Moreover, mouse NSC-34 neuron...
The ideal characteristics of surface modification on the vascular graft for clinical application would be with excellent hemocompatibility, endothelialization capacity, and antirestenosis ability. Here, Fourier transform infrared spectroscopy (FTIR), enhanced Raman (SERS), atomic force microscopy (AFM), contact angle (θ) measurement, thermogravimetric analysis (TGA) were used to evaluate chemical mechanical properties collagen-gold nanocomposites (collagen+Au) 17.4, 43.5, 174 ppm Au...
Aflatoxins are carcinogenic secondary metabolites of fungi that contaminate many staple crops and foods. Aflatoxin contamination is a worldwide problem, especially in developing countries, posing health hazards, e.g., causing aflatoxicosis hepatocellular carcinoma, even death. Biological solutions for aflatoxin detoxification environmentally friendly cheaper alternative than chemical methods. The aims the current study were to investigate: (1) ability MSMEG_5998, an aflatoxin-degrading...
Gold nanoparticles (AuNPs) were fabricated with biocompatible collagen (Col) and then conjugated berberine (BB), denoted as Au-Col-BB, to investigate the endocytic mechanisms in Her-2 breast cancer cell line bovine aortic endothelial cells (BAEC). Owing superior biocompatibility, tunable physicochemical properties, potential functionalization biomolecules, AuNPs have been well studied carriers of biomolecules for diseases therapeutics. Composites biopolymer, such fibronectin or Col, revealed...
Parkinson's disease (PD) is a degenerative that can cause motor, cognitive, and behavioral disorders. The treatment strategies being developed are based on the typical pathologic features of PD, including death dopaminergic (DA) neurons in substantia nigra midbrain accumulation α-synuclein neurons. Peiminine (PMN) an extract Fritillaria thunbergii Miq has antioxidant anti-neuroinflammatory effects. We used Caenorhabditis elegans SH-SY5Y cell models PD to evaluate neuroprotective potential...