A5080299919- Astrophysical Phenomena and Observations
- Advanced X-ray Imaging Techniques
- Particle Detector Development and Performance
- Gamma-ray bursts and supernovae
- Pulsars and Gravitational Waves Research
- Astrophysics and Cosmic Phenomena
- Advanced Surface Polishing Techniques
- Adaptive optics and wavefront sensing
- Nuclear Physics and Applications
- High-pressure geophysics and materials
- Particle Accelerators and Free-Electron Lasers
- Radiation Detection and Scintillator Technologies
- X-ray Spectroscopy and Fluorescence Analysis
- Crystallography and Radiation Phenomena
- Superconducting Materials and Applications
- Calibration and Measurement Techniques
- Advanced Semiconductor Detectors and Materials
- Thin-Film Transistor Technologies
- Astronomy and Astrophysical Research
- Colorectal Cancer Treatments and Studies
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Galaxies: Formation, Evolution, Phenomena
- Stellar, planetary, and galactic studies
- Astronomical Observations and Instrumentation
Hôpital Européen
2016-2025
Cosine (Netherlands)
2015-2024
Politecnico di Milano
2023
Brera Astronomical Observatory
2022-2023
University of Leicester
2023
University of California, Berkeley
2010-2018
Aix-Marseille Université
2018
National Institute for Astrophysics
2009-2017
Hôpital Ambroise-Paré
2014
Laboratoire d'Analyse et d'Architecture des Systèmes
2006-2011
The Nuclear Spectroscopic Telescope Array (NuSTAR) mission, launched on 2012 June 13, is the first focusing high-energy X-ray telescope in orbit. NuSTAR operates band from 3 to 79 keV, extending sensitivity of far beyond ∼10 keV cutoff achieved by all previous satellites. inherently low background associated with concentrating light enables probe hard sky a more than 100-fold improvement over collimated or coded mask instruments that have operated this bandpass. Using its unprecedented...
We report the discovery of 3.76 s pulsations from a new burst source near Sgr A* observed by NuSTAR observatory. The strong signal SGR J1745−29 presents complex pulse profile modulated with pulsed fraction 27% ± 3% in 3–10 keV band. Two observations spaced nine days apart yield spin-down rate =(6.5 1.4) × 10−12. This implies magnetic field B = 1.6 1014 G, power =5 1033 erg s−1, and characteristic age P/2 =9 103 yr for rotating dipole model. However, current may be erratic, especially during...
Some supernovae (SNe) may be powered by the interaction of SN ejecta with a large amount circumstellar matter (CSM). However, quantitative estimates CSM mass around such SNe are missing when material is optically thick. Specifically, current estimators sensitive to uncertainties regarding density profile and velocity. Here we outline method measure thick SNe. We present new visible-light X-ray observations 2010jl (PTF 10aaxf), including first detection an in hard band using NuSTAR. The total...
Sagittarius A* harbors the supermassive black hole that lies at dynamical center of our Galaxy. spends most its time in a low luminosity emission state but flares frequently infrared and X-ray, increasing up to few hundred fold brightness for hours time. The physical processes giving rise X-ray are uncertain. Here we report detection with NuSTAR observatory Summer Fall 2012 four medium amplitude energies 79 keV. For first time, clearly see power-law spectrum extends high energy, no evidence...
We present a statistical analysis of the X-ray flux distribution Sgr A* from Chandra Observatory's 3 Ms Visionary Project (XVP) in 2012. Our indicates that observed can be decomposed into steady quiescent component, represented by Poisson process with rate $Q=(5.24\pm0.08)\times10^{-3}$ cts s$^{-1},$ and variable power law ($dN/dF\propto F^{-\xi},$ $\xi=1.92_{-0.02}^{+0.03}$). This slope matches our recently-reported flare luminosities. The variability may also described log-normal median...
Immune checkpoint inhibitors (ICIs) are responsible for causing immune-related adverse events (irAEs). The frequency and severity of irAEs depend on various factors, but the role molecule used remains unclear. Our aim was to assess comparative safety profile different programmed cell death-1 (anti-PD1) death ligand-1 (anti-PD-L1) in a real-life setting. occurrence severe (grade ≥3) their characteristics were recorded all patients treated with anti-PD1 or anti-PD-L1, alone combination, at our...
We present the first sub-arcminute images of Galactic Center above 10 keV, obtained with NuSTAR. NuSTAR resolves hard X-ray source IGR J17456–2901 into non-thermal filaments, molecular clouds, point sources, and a previously unknown central component emission (CHXE). detects four extending detection their power-law spectra Γ ∼ 1.3–2.3 up to ∼50 keV. A morphological spectral study filaments suggests that origin may be heterogeneous, where previous studies suggested common in young pulsar wind...
We present the first survey results of hard X-ray point sources in Galactic Center (GC) region by NuSTAR. have discovered 70 (3-79 keV) a 0.6 deg^2 around Sgr A* with total exposure 1.7 Ms, and 7 B2 field 300 ks. identify clear Chandra counterparts for 58 NuSTAR assign candidate remaining 19. The reaches luminosities ~4 x ~8 10^32 erg s^-1 at GC (8 kpc) 3-10 10-40 keV bands, respectively. source list includes three persistent luminous binaries likely run-away pulsar called Cannonball. New...
The ATHENA mission, a European large (L) class X-ray observatory to be launched in 2028, will essentially consist of an lens and two focal plane instruments. lens, based on Wolter-I type double reflection grazing incidence angle design, very (~ 3 m diameter) meet the science requirements effective area (1-2 m<sup>2</sup> at few keV) length 12 m. To high angular resolution (5 arc seconds) requirement also need accurate. Silicon Pore Optics (SPO) technology has been invented enable building...
Crystals are the elementary constituents of Laue lenses, an emerging technology which could allow realization a space-borne telescope 10–100 times more sensitive than existing ones, in 100 keV–1.5 MeV energy range. This paper addresses development efficient crystals for lens. In theoretical part, 35 candidate crystals, both pure and two-component considered. Their peak reflectivity at 100, 500 keV 1 is calculated assuming they mosaic crystals. It found that, by careful selection it possible...
We present a new way of describing the flares from Sgr A* with self-consistent calculation particle distribution. All relevant radiative processes are taken into account in evolution electron distribution and resulting spectrum. spectral modelling for X-ray observed by NuSTAR, together older observations different wavelengths, discuss changes plasma parameters to produce flare. show that under certain conditions, real can differ significantly standard distributions assumed most studies....
We report on two NuSTAR observations of GRS 1741.9-2853, a faint neutron star low mass X-ray binary burster located 10' away from the Galactic center. detected source serendipitously as it was emerging quiescence: its luminosity $6\times 10^{34}$ erg~s$^{-1}$ 2013 July 31, and $5\times 10^{35}$ in second observation August 3. A bright, 800-s long, H-triggered mixed H/He thermonuclear Type I burst with mild photospheric radius expansion (PRE) present during observation. Assuming that PRE at...
The Arches cluster is a young, densely packed massive star in our Galaxy that shows high level of formation activity. nature the extended non-thermal X-ray emission around remains unclear. observed bright Fe Kα line at 6.4 keV from material neutral or low ionization state can be produced either by photoionization cosmic-ray particle bombardment both. In this paper, we report on first detection above 10 with NuSTAR mission, and present results its morphology spectrum. spatial distribution...
A new X-ray parallel beam facility (XPBF 2.0) has been installed in the laboratory of Physikalisch-Technische Bundesanstalt at synchrotron radiation BESSY II Berlin to characterize silicon pore optics (SPOs) for future observatory ATHENA. As existing XPBF which is operated since 2005, beamline provides a pencil very low divergence, vacuum chamber with hexapod system accurate positioning SPO be investigated, and vertically movable CCD-based camera register direct reflected beam. In contrast...
The diffraction properties of a crystalline silicon plate which one face was mechanically indented have been studied. This treatment induced permanent curvature in the sample, allowed efficiency 88% for 150 keV photons, i.e. reflectivity 64% including absorption. is constant over 14 arcseconds and very close to theoretical expectation, meaning that highly homogeneous. technique enables fabrication, reproducible fashion, crystals realization an astronomical hard X-ray concentrator (Laue lens).
Understanding the origin of flaring activity from Galactic center supermassive black hole, Sagittarius A*, is a major scientific goal NuSTAR plane survey campaign. We report on data obtained between July 2012 and April 2015, including 27 observations Sgr A* with total exposure ~ 1 Ms. found ten X-ray flares detected in observation window, luminosities range $L_{3-79~keV}$~$(0.2-4.0) \times 10^{35}~erg~s^{-1}$. With this largest hard flare dataset to date, we studied spectral properties....
Silicon Pore Optics is a high-energy optics technology, invented to enable the next generation of high-resolution, large area X-ray telescopes such as ATHENA observatory, European (L) class mission with launch date 2028. The technology development carried out by consortium industrial and academic partners focuses on building an focal length 12 m that shall achieve angular resolution better than 5". So far we have built 50 20 m. This paper presents details work build silicon stacks for...
4019 Background: The incidence of SRC gastric cancers is markedly increasing in Western countries. may harbor intrinsic resistance to chemotherapy (CTx) leaving many clinicians unsure the benefits delaying surgery pursue a neoadjuvant approach. primary objective this study was assess whether upfront plus adjuvant CTx would provide enough survival benefit for phase III trial when compared perioperative CTx. Methods: Patients with stage IB-III cancer were randomly assigned receive (epirubicin,...
The Beam Expander Testing X-ray facility (BEaTriX) is a unique apparatus now operated at the Istituto Nazionale di Astrofisica (INAF), Osservatorio Astronomico Brera (OAB), in Merate, Italy. It has been specifically designed to measure point spread function (PSF) and effective area (EA) of mirror modules (MMs) Advanced Telescope for High-ENergy Astrophysics (ATHENA), based on silicon pore optics (SPO) technology, verification before integration into assembly. To this end, BEaTriX generates...
Silicon Pore Optics (SPO), developed at cosine with the European Space Agency (ESA) and several academic industrial partners, provides lightweight, yet stiff, high-resolution x-ray optics. This technology enables ATHENA to reach an unprecedentedly large effective area in 0.2 - 12 keV band angular resolution better than 5''. After developing for 50 m 20 focal length, this year has witnessed first length mirror modules being produced. The development is also gaining momentum three different...
Athena, the largest space-based x-ray telescope to be flown by European Space Agency, uses a revolutionary new modular technology assemble its 2.6 m diameter lens. The lens will consist of several hundreds smaller lenslets, called mirror modules, which each about 70 pairs. Those modules are arranged in circles large optics structure and focus photons with an energy 0.5 10 keV at distance 12 onto detectors Athena. point-spread function (PSF) optic shall achieve half-energy width (HEW) 5" 1...