A5055768729- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Bacterial Genetics and Biotechnology
- Immune Response and Inflammation
- Plant Molecular Biology Research
- Birth, Development, and Health
- Bacterial biofilms and quorum sensing
- Sirtuins and Resveratrol in Medicine
- Protein Structure and Dynamics
- Endoplasmic Reticulum Stress and Disease
- Celiac Disease Research and Management
- Hearing Loss and Rehabilitation
- Helicobacter pylori-related gastroenterology studies
- Bacillus and Francisella bacterial research
- Peptidase Inhibition and Analysis
- Computational Drug Discovery Methods
- Digestive system and related health
- Nutrition, Genetics, and Disease
Tel Aviv University
2018-2024
Hebrew University of Jerusalem
2011-2016
Noise-induced hearing loss (NIHL) results from a complex interplay of damage to the sensory cells inner ear, dysfunction its lateral wall, axonal retraction type 1C spiral ganglion neurons, and activation immune response. We use RiboTag single-cell RNA sequencing survey cell-type-specific molecular landscape mouse ear before after noise trauma. identify induction transcription factors STAT3 IRF7 immune-related genes across all cell-types. Yet, transcriptomic changes dominate The ATF3/ATF4...
ABSTRACT CAPRI rounds 28 and 29 included, for the first time, peptide‐receptor targets of three different systems, reflecting increased appreciation importance peptide‐protein interactions. The allowed us to objectively assess performance Rosetta FlexPepDock, one protocols explicitly include peptide flexibility in docking, accounting conformational changes upon binding. We discuss here successes challenges modeling these targets: we obtain top‐performing, high‐resolution models motif cases...
Nutrient deprivation (starvation) induced by fasting and hypercaloric regimens are stress factors that can influence cell tissue homeostasis in mammals. One of the key cellular responses to changes nutrient availability is survival pathway autophagy. While there has been much research into protein networks regulating autophagy, less known about gene expression involved this fundamental process. Here, we applied a network algorithm designed analyse omics datasets, identify sub-networks...
Cochlear supporting cells (SCs) are glia-like critical for hearing function. In the neonatal cochlea, greater epithelial ridge (GER) is a mitotically quiescent and transient organ, which has been shown to nonmitotically regenerate SCs. Here, we ablated Lgr5 + SCs using Lgr5-DTR mice found mitotic regeneration of by GER in vivo. With lineage tracing, show that houses progenitor robustly divide migrate into organ Corti replenish Regenerated display coordinated calcium transients, markers SC...
Introduction Mutations in microRNA-96 (miR-96), a microRNA expressed within the hair cells (HCs) of inner ear, result progressive hearing loss both mouse models and humans. In this study, we present first HC-specific RNA-sequencing (RNA-seq) dataset from newborn Mir96 Dmdo heterozygous, homozygous mutant, wildtype mice. Methods Bulk RNA-seq was performed on HCs Differentially gene analysis conducted mutant compared to littermate controls, followed by GO term protein-protein interaction these...
The peripheral and central auditory subsystems together form a complex sensory network that allows an organism to hear. genetic programs of the two must therefore be tightly coordinated during development. Yet, their interactions common expression pathways have never been systematically explored. MicroRNAs (miRNAs) are short non-coding RNAs regulate gene essential for normal development system. We performed mRNA small-RNA sequencing organs from both at three critical developmental timepoints...