A5034956931- Sperm and Testicular Function
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Urological Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Signaling Pathways in Disease
- Tissue Engineering and Regenerative Medicine
- Testicular diseases and treatments
- Ovarian function and disorders
- Genetics, Aging, and Longevity in Model Organisms
University of South Florida
2025
Bülent Ecevit University
2020-2023
Sağlık Bilimleri Üniversitesi
2020
To study the relationship between FK506-binding protein 51 (FKBP51) and ovarian aging and/or diminished reserve (DOR) in human ovaries by comparing FKBP51 levels granulosa (GC) cumulus cells (CC), collected during controlled stimulation (COS) from women of advanced reproductive age with a diagnosis DOR that young normal reserve. explore association increased expression further, was compared stroma post-menopausal versus pre-menopausal women. Lastly, this relation further queried several...
Prenatal stress (PNS) impairs offspring ovarian development by exerting negative long-term effects on postnatal function and folliculogenesis. FKBP51 is a stress-responsive protein that inhibits glucocorticoid progesterone receptors. We hypothesize contributes to impaired folliculogenesis induced PNS. Timed-pregnant Fkbp5+/+ (wild-type) Fkbp5−/− (knockout) mice were randomly assigned either the undisturbed (nonstress) or PNS group, with exposure maternal restraint from embryonic days 8 18....
Abstract Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality, with maternal stress-related disorders, such as depression anxiety, linked to idiopathic PTB (iPTB). At the maternal-fetal interface, decidualized stromal cells (DSCs) exclusively express progesterone receptor (PR) play pivotal roles in maintaining pregnancy initiating labor. DSCs also FKBP51, protein that binds inhibits transcriptional activity glucocorticoid PR receptors associated diseases. We previously...
Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. Infertility is a global with high prevalence. Non-obstructive azoospermia may occur due to genetic factors, exposure toxic substances, anticancer treatments such as radiotherapy and chemotherapy testicular torsion. experiments been conducted determine efficacy MSCs treatment male infertility their differentiation capacity paracrine effect. In these studies, capacities...
Yapılan pek çok yeni çalışmada, mezenkimal kök hücrelerin (MSC) farklı hastalık modellerinde terapötik etkileri gösterilmiştir. İnfertilite, yaygınlığı yüksek küresel bir olup erkek faktörü, azalmış over rezervi, ovulatuar faktör, tubal uterin pelvik faktör ve açıklanamayan infertilite nedeniyle ortaya çıkabilir. MSC'lerin, farklılaşma kapasiteleri parakrin etki özellikleri nedeniyle, ovaryan yetmezlik tedavisindeki etkilerini belirlemek için birçok çalışma yapılmıştır. Araştırmalarda...