Soy isoflavones sensitize prostate cancer cells to radiation therapy by inhibiting cell survival pathways activated radiation. At the same time, soy have significant antioxidant and anti-inflammatory activity, which may help prevent side effects of Therefore, we hypothesized that could be useful when given in conjunction with curative patients localized cancer. In addition enhancing efficacy therapy, adverse We conducted a pilot study investigate isoflavone supplementation on acute subacute...

The goal of this study was to explore the perspectives and practice radiation oncologists who treat breast cancer patients have had reconstruction.In 2010, an original electronic survey sent all physician members American Society Radiation Oncology, National Cancer Research Institute-Breast Studies Group in United Kingdom, Thai Therapeutic Radiology Swiss Turkish Oncology Society. We identified factors associated with reconstruction performed prior obtained information regarding management...

The study aimed to calculate chest-wall skin dose associated with different frequencies of bolus applications in post-mastectomy three-dimensional conformal radiotherapy (3D-CRT) and provide detailed information the selection an appropriate regimen this clinical setting. CT-Simulation scans 22 patients were used. Chest wall for target volume (CTV) a including 2-mm surface thickness chest structures delineated. Precise PLAN 2.11 treatment planning system (TPS) was used 3D-CRT planning. 50 Gy...

We conducted a study to investigate if lycopene could reduce gastrointestinal toxicity of abdominal and pelvic radiation in Wistar albino rats. Animals received either control diet (Group 1), lycopene-supplemented 2), 3), plus 4). In Groups 2 4, the rats 5 mg/kg/day for 10 days. 3 single fraction 8 Gy (RT) on Day 10. Study endpoints included weight loss, diarrhea, duration survival, an oxidative stress marker, plasma level thiobarbituric acid reactive substance (TBARS). The receiving RT only...

To evaluate the relationship between fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) maximum standardized uptake value (SUV(max)) and pain response to radiation therapy (RT) in patients with bone metastasis.Institutional ethical board approval for study was obtained, informed consent, this prospective study. Thirty-one metastatic who underwent FDG PET/computed before RT were included. Patients diagnosed lung (n = 16), breast 7), stomach 2), head neck cancers 3), as...

This study aimed to analyze three-dimensional (3D) dosimetric data of conventional two-dimensional (2D) palliative spinal bone irradiation using different reference points and treatment plans with respect the International Commission on Radiation Units Measurements (ICRU) Report 50. Forty-five simulation CT scans 39 patients previously treated for thoraco-lumbar metastases were used. Three created: (1) single posterior field ICRU (ICRUrps); (2) Bone Metastasis Consensus Working Party...

Optimal treatment of high-risk prostate cancer remains controversial. We aimed to compare outcomes patients treated with definitive external-beam radiotherapy (ExRT) or radical prostatectomy (RP). The records 120 clinical stage T2b-T4 N0 M0 ExRT RP were reviewed. Patients pretreatment prostate-specific antigen (PSA) levels ≥20 ng/mL ≥T3 Gleason score (GS) ≥8 included in the study. Biochemical failure free survival (BFFS), distant metastasis (DMFS), cancer-specific (CSS) and overall (OS)...

The authors compared treatment adherence rates and outcome in Caucasian African American patients with inflammatory breast cancer (IBC).The records of 55 (25 30 American) IBC treated curative intent from 1995 to 2009 were reviewed. All received neoadjuvant doxorubicin (Adriamycin) and/or taxane-based chemotherapy, mastectomy or without radiotherapy. median follow-up period for was similar (39.5 months 36.1 months, respectively).There no difference between races age, tumor size, grade,...

We aimed to research whether lycopene (L) could prevent radiation-induced acute esophageal toxicity in Wistar albino rats. 60 rats were placed five groups as follows: control, L, radiotherapy (RT), L before RT (L + RT), and after L). 6 mg/kg bw/day was administered 7 days the group, group. 35 Gy thoracic performed. Serum levels measured, esophagi evaluated histopathologically for intraepithelial degenerative changes-necrosis, vacuole formation, inflammation, regeneration-mitosis,...

The aim of this study was to explore whether an in-house dosimetry protocol and optimisation method are able produce a homogeneous dose distribution in the target volume, how often is required vaginal cuff brachytherapy. Treatment planning carried out for 109 fractions 33 patients who underwent high rate iridium-192 (Ir(192)) brachytherapy using Fletcher ovoids. Dose prescription normalisation were performed catheter-oriented lateral points (dps) within range 90-110% prescribed dose. apex...

The aim of this study was to compare the dosimetric data from conventional two-dimensional (2D) helmet-field whole-brain irradiation (WBI) with those three-dimensional conformal radiotherapy (3D-CRT), and investigate potential benefits 3D-CRT as regards both dose coverage brain retro-orbital (RO) area ocular lens protection. Simulation CT scans 30 patients were used. In planning, brain, optic nerves, lenses RO areas contoured. Two opposed lateral fields used matched non-divergently behind...

In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), administered at 5 mg/kg/days for 7 days, RT (RT), before (J + RT), seven days RT, both and after J), 3 days. The weights rats measured on the 1st, 7th, 10th study. sacrificed to obtain tissues from liver intestine, which was followed by taking blood samples...

Summary The aim of this study was to assess the effect Trendelenburg position in comparison prone on small bowel volume and treatment dose gynecologic pelvic external beam radiotherapy using three‐dimensional conformal plans. Eight patients with cancers, treated definitive or postoperative were investigated. Pelvic computerized tomography (CT) scans for planning performed 25 degree positions each patient. dose‐volume histograms within fields obtained compared both positions. clinical target...

Purpose To evaluate the relationship between fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) maximum standardized uptake value (SUVmax) and pain response to radiation therapy (RT) in patients with bone metastasis. Materials Methods Institutional ethical board approval for study was obtained, informed consent, this prospective study. Thirty-one metastatic who underwent FDG PET/computed before RT were included. Patients diagnosed lung (n = 16), breast 7), stomach 2),...

Total body irradiation is used in conjunction with chemotherapy as a conditioning regimen the treatment of many disease such leukemia, myelodysplastic syndrome, aplastic anemia, multiple myeloma and lymphoma prior to hematopoetic stem cell transplantation.The main purposes transplantation are eradication recipient bone marrow any residual cancer cells, creation space receipient for donor immunosuppression prevent rejection cells case an allotransplant.

Erken teşhis ve tedavi yöntemlerindeki gelişmeler sonrasındaki destek bakımlarla hayatta kalan kanserli hasta oranı gittikçe artmaktadır. Bu durum, söz konusu hastalarda uygulanan tedavilere bağlı olarak, geç dönem yan etkilerin daha çok görülmesine de neden olabilmektedir. Radyoterapi (RT), hastaların hem primer, adjuvan palyatif tedavisinde yaygın olarak kullanılan bir yöntemdir. Radyoterapinin en ciddi etkilerinden biri radyasyona ikincil kanserlerdir. Radyasyona kanser, maruz kalındıktan...