A5101727029- Lung Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Mitochondrial Function and Pathology
- Advanced Radiotherapy Techniques
- Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Metabolism and Genetic Disorders
- HIV Research and Treatment
- Breast Implant and Reconstruction
- Cytomegalovirus and herpesvirus research
- Chronic Disease Management Strategies
- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Cancer Studies
- HIV-related health complications and treatments
- Autophagy in Disease and Therapy
- Retinal and Macular Surgery
- Biliary and Gastrointestinal Fistulas
- Endometrial and Cervical Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Inflammatory Bowel Disease
University of Ulsan
2008-2025
Asan Medical Center
2006-2025
Ulsan College
2025
University of British Columbia
2023-2025
Jewish General Hospital
2024
Samsung Medical Center
2019
Public Health Agency of Canada
2019
Northwestern Memorial Hospital
2017
University of North Carolina at Chapel Hill
2003
Abstract Background Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease, particularly ulcerative colitis. Despite its clinical significance, the spatiotemporal dynamics neoplastic progression in CAC remain poorly understood. This study aimed to elucidate evolutionary trajectory using spatial transcriptomics. Methods We employed transcriptomics analyze four tissue samples from three patients with colitis at various stages progression. Whole-slide...
Abstract Diffuse large B-cell lymphoma (DLBCL) relapses in approximately 40% of patients following frontline therapy. We reported that STAT6 D419 mutations are enriched relapsed/refractory DLBCL (rrDLBCL) samples, suggesting JAK/STAT signaling plays a role therapeutic resistance. hypothesized can improve cell survival by reprogramming the microenvironment to sustain activation. Thus, we investigated on growth and its microenvironment. found phospho-STAT6 D419N was retained nucleus longer...
The Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) study is a prospective, multicenter, Canadian cohort investigating human immunodeficiency virus-1 (HIV-1) reservoirs, chronic inflammation, and immune responses in children with perinatally acquired HIV-1 infection. focus of this report reservoirs correlates the peripheral blood who achieved sustained virologic suppression (SVS) for ≥5 years.HIV-1 were determined by measuring DNA mononuclear cells inducible cell-free RNA CD4+...
The International Council of Nurses supports the development Classification for Nursing Practice® (ICNP®) catalogues to support construction electronic health records and evidence-based practice. Such a catalogue is needed inpatient falls.The ICNP®-Based Inpatient Fall-Prevention Catalogue ('The Catalogue') was developed following six steps recommended by Nurses: (1) identifying falls as priority, (2) gathering relevant concepts from 10 international guidelines comparing locally defined sets...
Purpose: The purpose of this work was to describe the changes primary tumor and mediastinal lymph nodes on CT after neoadjuvant concurrent chemoradiotherapy correlate findings with pathology. Method: Twenty-one consecutive patients [N2 disease (n = 19) or resectable T4 N2 2)] non-small cell lung cancer underwent chemoradiotherapy. Changes before therapy were assessed using CT. correlated pathologic findings. Results: With therapy, decrease in T stage achieved 9 21 (43%) On pathology,...
The proportion and significance of HIV-1 infection CD8+ T-cells was examined in a patient cohort seropositive (n=28) seronegative individuals (n=4). It hypothesized that irrespective the clinical status patients, productively infected would be found these cells contribute to plasma viral load vivo. Flow cytometric analysis using fluorochrome-conjugated antibodies, RT-PCR HIV-1(pol) specific primers, quantification transcripts by ex vivo culture isolated were employed. In 22 28 samples...
Abstract Mitochondria require the constant import of nuclear-encoded proteins for proper functioning. Impaired protein not only depletes mitochondria essential factors but also leads to toxic accumulation un-imported outside organelle. Defects in mitochondrial are associated with neurodegenerative and bioenergetic diseases. Here, we investigated consequences stress human cells. We demonstrated that can clog by stalling inside translocase outer membrane (TOM). found integrated response (ISR)...
Purpose: To present a case of post-traumatic dislocation the WIOL-CF<sup>®</sup> accommodating intraocular lens (IOL), composed hydrogel material and featuring full-optic body design, in vitrectomized eye, highlighting considerations for surgical correction.Case summary: A 54-year-old man with history left-eye implantation vitrectomy experienced sudden onset vision deterioration left eye following trauma. The IOL was dislocated due to posterior capsule rupture, anterior...
4050 Background: We conducted a prospective randomized trial to define the optimal sequence of chemotherapy and radiotherapy postoperative adjuvant treatment in stage II III rectal cancer. Methods: Three hundred eight patients were enrolled onto study. randomly assigned 155 arm I (early group) 153 (late group). Treatment included cycles at 4-week intervals pelvic 45 Gy 25 fractions. Radiotherapy started on day 1 first cycle third II. The regimen consisted fluorouracil 375 mg/m 2 /d...
8570 Background: The combination of rituximab and CHOP chemotherapy (R-CHOP) has improved survival patients with diffuse large B-cell lymphoma (DLBCL). Recently, several reports have shown that standard International Prognostic Index (IPI) became less powerful prognostic predictor in DLBCL the era R-CHOP. We evaluated factors treated Detailed analysis was planned regarding number extranodal sites because its higher frequency Korea. Methods: Between January 2002 May 2008, 126 stage III/IV...