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A5101523454
Research Areas
- Medicinal Plant Pharmacodynamics Research
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Fungal Infections and Studies
Abstract Icaritin, a small molecule currently being investigated in phase III clinical trials China (NCT03236636 and NCT03236649) for treatment of advanced hepatocellular carcinoma (HCC), is prenylflavonoid derivative obtained from the Epimedium genus . Previously, it was found that Icaritin decreased expression PD‐L1, but its direct molecular targets underlying mechanisms have not been identified. In this study, we report identification IKK‐α as protein target by biotin‐based affinity...
10.1002/eji.202048905
article
EN
cc-by-nc-nd
European Journal of Immunology
2020-12-23
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