Eugenol, the generic name of 4-allyl-2-methoxyphenol, is major component clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain terminals like hydrogen, hydroxyl, ester, chlorine, carboxylic acid, were synthesized in present work. These compounds later subjected to epoxidation conditions give corresponding oxiranes. All derivatives evaluated against their effect...

Thymol and carvacrol derivatives were synthesised. Two of them proved to be mildly active against Sf9 insect cell line one has presented selectivity by proving less toxic human cells than the naturally derived starting materials.

Eugenol, 4-allyl-2-methoxyphenol, is the main constituent of clove essential oil and has demonstrated relevant biological activity, namely anticancer activity. Aiming to increase this we synthesized a series eugenol β-amino alcohol β-alkoxy derivatives, which were then tested against two human cancer cell lines, gastric adenocarcinoma cells (AGS) lung (A549). An initial screening was performed identify most cytotoxic compounds. The results that three derivatives had activity justified...

A series of β-amino alcohols were prepared by the reaction eugenol epoxide with aliphatic and aromatic amine nucleophiles. The synthesized compounds fully characterized evaluated as potential insecticides through assessment their biological activity against Sf9 insect cells, compared a commercial synthetic pesticide (chlorpyrifos, CHPY). Three derivatives bearing terminal benzene ring, either substituted or unsubstituted, identified most potent molecules, two them displaying higher toxicity...

A series of catecholamines (dopamine, norepinephrine, tyramine and octopamine) their corresponding amino acid precursors in the biosynthetic pathway, L-phenylalanine, L-tyrosine L-3,4-dihydroxyphenylalanine (DOPA), were reacted with 1-hydroxymethylpyrene presence N,N′-carbonyldiimidazole (CDI). Photolysis studies on carbamate conjugates carried out under irradiation at different wavelengths (250, 300, 350 nm), followed by HPLC/UV 1H NMR, aim evaluating applicability N-pyrenylmethoxycarbonyl...

The search for graphene or few-layer production methods that are simple, allow mass production, and yield good quality material continues to provoke intense investigation. present work contributes this investigation through the study of aqueous exfoliation four types sources, which namely graphite nanoflakes with different morphologies geographical origins. was achieved in an solution a soluble pyrene derivative synthesized achieve maximum interaction surface at low concentration (5 × 10-5...

Article A Simple and Sensitive Spectrophotometric Determination of Monoamine Oxidase Activity was published on January 1, 1973 in the journal Clinical Chemistry Laboratory Medicine (CCLM) (volume 11, issue 9).

A recently synthesized new eugenol derivative, ethyl 4-(2-methoxy-4-(oxiran-2-ylmethyl)phenoxy)butanoate, with a high insecticidal activity against Sf9 (Spodoptera frugiperda) insect cells, was encapsulated in the liposomal formulations of egg-phosphatidylcholine/cholesterol (Egg-PC:Ch) 70:30 and 100% dioleoylphosphatidylglycerol (DOPG), aiming at future application as insecticides. Compound-loaded DOPG liposomes have sizes 274 ± 12 nm, while Egg-PC:Ch exhibit smaller hydrodynamic diameters...

A series of azo dyes containing eugenol, the major phenolic compound in clove (Syzygium aromaticum) essential oil, was synthesized by coupling reactions diazonium salts different amines based on 3-aminobenzoic acid with eugenol. The new eugenol-based were fully characterized usual analytical techniques and used preliminary reactive dyeing tests polyamide fabric to determine colour fastness staining under domestic washing conditions. results obtained revealed potential these for applications...

Semisynthetic eugenol derivatives with insecticidal activity and potential affinity for an odorant binding protein 1 acetylcholinesterase were efficiently nanoencapsulated released.

Natural products belonging to different chemical classes have been established as a promising source of novel anticancer drugs. Several low-molecular-weight compounds from the monoterpenes, phenylpropanoids, and flavonoids were shown possess activities in previous studies. In this work, over 20 semisynthetic derivatives molecules these classes, namely thymol, eugenol, 6-hydroxyflavanone synthesized tested for their cytotoxicity against two human cancer cell lines, AGS cells (gastric...

A new set of alkoxy alcohols were synthesised by reaction eugenol oxirane with aliphatic and aromatic alcohols. These derivatives evaluated against their effect upon the viability insect cell line Sf9 (Spodoptera frugiperda).The most promising compounds, 4-(3-(tert-butoxy)-2-hydroxypropyl)-2-methoxyphenol 4-(2-((4-fluorobenzyl)oxy)-3-hydroxypropyl)-2-methoxyphenol submitted to in silico assays predict possible targets. Thought an Inverted Virtual Screening approach, 23 common pesticide...

The search for graphene or few layer production methods that are simple, allow mass and yield good quality material continues to provoke intense investigation. present work contributes through the study of aqueous exfoliation four types sources, namely graphite nanoflakes with different morphologies geographical origin. was achieved in an solution a soluble pyrene derivative synthesized achieve maximum interaction surface at low concentration (5 x 10-5 M). bilayer obtained quantified by...

Eugenol is a major constituent of clove essential oil with interesting biological activity, namely antimicrobial and antioxidant. Structural changes eugenol are useful strategy in order to improve activity at the same time obtain new analogues reduced side effects. In this work, series amine nucleophiles were reacted epoxide so as corresponding amino alcohols, considering their potential biopesticides. These alcohols evaluated against insect cells, specifically Sf9 cell line.

Essential oils (EOs) have been studied owing to their properties, such as remarkable biological activities and health promoting benefits, including analgesic, anti-inflammatory, antibiotic, antioxidant antimicrobial activities, well potential insecticides. In spite of all EOs present low water solubility, poor bioavailability, volatility, reduced stability, resistance environmental stresses like light, oxygen, temperature which difficult applications. To mitigate these limitations, can be...

The control of insect pests and the need for increased food production due to world population growth, together with environmental issues associated synthetic pesticides, has stimulated development new "greener" alternatives, based on natural compounds. Eugenol is a compound that major component clove oil. It demonstrated antimicrobial antioxidant activity, being also powerful insecticide. Recently, eugenol derivatives have been developed, some molecules displaying insecticide activity. One...

Three new carvacrol derivatives 1–3 possessing aliphatic carbon chains with different sizes as hydroxyl group substituents were synthesized in order to evaluate their insecticidal activity against the insect cell line Sf9 (Spodoptera frugiperda).