A5100668619- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Conducting polymers and applications
- Neural dynamics and brain function
- Advanced Sensor and Energy Harvesting Materials
- Advanced Memory and Neural Computing
- Transcranial Magnetic Stimulation Studies
- Photoreceptor and optogenetics research
- Electrochemical sensors and biosensors
- Thin-Film Transistor Technologies
- Primate Behavior and Ecology
- Near-Field Optical Microscopy
- Analytical Chemistry and Sensors
- Nanowire Synthesis and Applications
- Force Microscopy Techniques and Applications
- Antifungal resistance and susceptibility
- Graphene and Nanomaterials Applications
- Tactile and Sensory Interactions
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Phytochemistry and Biological Activities
- Photosynthetic Processes and Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Neural Networks Stability and Synchronization
Center for Translational Neurophysiology of Speech and Communication
2016-2024
Italian Institute of Technology
2012-2024
University of Genoa
1993-2021
La Jolla Bioengineering Institute
2018
University of California, San Diego
2018
Union des Industries Ferroviaires Européennes
2016
IRBM Science Park
2013
Abstract We report on the superior electrochemical properties, in-vivo performance and long term stability under electrical stimulation of a new electrode material fabricated from lithographically patterned glassy carbon. For direct comparison with conventional metal electrodes, similar ultra-flexible, micro-electrocorticography (μ-ECoG) arrays platinum (Pt) or carbon (GC) electrodes were manufactured. The GC microelectrodes have more than 70% wider window higher CTC (charge transfer...
Extracellular metal microelectrodes are widely used to record single neuron activity in vivo. However, their signal-to-noise ratio (SNR) is often far from optimal due high impedance value. It has been recently reported that carbon nanotube (CNT) coatings may decrease microelectrode impedance, thus improving performance. To tease out the different contributions SNR of CNT-coated we carried and noise spectroscopy measurements platinum/tungsten coated with a polypyrrole–CNT composite. Neuronal...
Electrocorticography (ECoG) is becoming a common tool for clinical applications, such as preparing patients epilepsy surgery or localizing tumor boundaries, it successfully balances invasiveness and information quality. Clinical ECoG arrays use millimeter-scale electrodes centimeter-scale pitch cannot precisely map neural activity. Higher-resolution are of interest both current providing access to more precise activity localization novel prosthetics, where density spatial resolution...
Conductive tattoo nanosheets are fabricated on top of decal transfer paper and transferred target surfaces as temporary tattoos. Circuits patterned with ink-jet printing. Tattoo envisioned unperceivable human–device interfaces because conformal adhesion to complex including skin. They tested dry electrodes for surface electromyography (sEMG), which permits the control a robotic hand.
Finding the most appropriate technology for building electrodes to be used long term implants in humans is a challenging issue. What are technologies? How could one achieve robustness, stability, compatibility, efficacy, and versatility, both recording stimulation? There no easy answers these questions as even fundamental apparently obvious factors taken into account, such necessary mechanical, electrical biological properties, their interplay, under debate. We present here our approach...
We report for the first time how coatings made by directly growing carbon nanotubes (CNTs) on tip of neural microelectrodes outperform others electrodeposited CNT composites. Not only do they reduce microelectrode impedance but also are able to inject high currents without degradation and stable in time. These results suggest that excellent candidates chronic applications especially when both recording stimulation have be performed same microelectrode.
The ongoing interest in densely packed miniaturized electrode arrays for high-resolution epicortical recordings has induced many researchers to explore the use of nanomaterial coatings reduce impedance while increasing signal-to-noise ratio and charge injection capability. Although these materials are very effective, their clinical practice is strongly inhibited by concerns about potential risks derived from nanomaterials direct contact with human brain. In this work we propose a novel...
Key points The cortical mechanisms of grasping have been extensively studied in macaques and humans; here, we investigated whether common marmosets could rely on similar despite strong differences hand morphology grip diversity. We recorded electrocorticographic activity over the sensorimotor cortex two during execution different types, which allowed us to study (power spectrum) physiologically inferred connectivity (phase‐slope index). Analyses were performed beta (16–35 Hz) gamma (75–100...
Abstract We report on a novel technology for microfabricating 3D origami-styled micro electro-mechanical systems (MEMS) structures with glassy carbon (GC) features and supporting polymer substrate. GC MEMS devices that open to form microstructures are microfabricated from patterns made through pyrolysis of precursors high-temperature resisting substrates like silicon or quartz then transferring the patterned flexible substrate polyimide followed by deposition an insulation layer. The folded...
The long-term reliability of neural interfaces and stability high-quality recordings are still unsolved issues in neuroscience research. High surface area PEDOT-PSS-CNT composites able to greatly improve the performance recording stimulation for traditional intracortical metal microelectrodes by decreasing their impedance increasing charge transfer capability. This enhancement significantly reduces size implantable device though preserving excellent electrical performances. On other hand,...
Abstract Thin‐film neural devices are an appealing alternative to traditional implants, although their chronic stability remains matter of investigation. In this study, a chronically stable class thin‐film for electrocorticography is manufactured incorporating silicon carbide and diamond‐like carbon as adhesion promoters between glassy (GC) electrodes polyimide GC platinum traces. The aged in three solutions—phosphate‐buffered saline (PBS), 30 × 10 −3 150 m H 2 O /PBS—and stressed using...
Abstract Localized drug delivery represents one of the most challenging uses systems based on conductive polymer films. Typically, anionic drugs are incorporated within polymers through electrostatic interaction with positively charged polymer. Following this approach, synthetic glucocorticoid dexamethasone phosphate is often delivered from neural probes to reduce inflammation surrounding tissue. In light recent literature neuroprotective and anti‐inflammatory properties tauroursodeoxycholic...
Neuromedin U (NMU) is an endogenous peptide implicated in the regulation of feeding, energy homeostasis, and glycemic control, which being considered for therapy obesity diabetes. A key liability NMU as a therapeutic its very short half-life vivo. We show here that conjugation to human serum albumin (HSA) yields compound with long circulatory half-life, maintains full potency at both peripheral central receptors. Initial attempts conjugate via prevalent strategy reacting maleimide derivative...
The authors present an electrochemically controlled, drug releasing neural interface composed of a glassy carbon (GC) microelectrode array combined with multilayer poly(3,4-ethylenedioxythiophene) (PEDOT) coating. system integrates the high stability GC electrode substrate, ideal for electrical stimulation and electrochemical detection neurotransmitters, on-demand drug-releasing capabilities PEDOT-dexamethasone compound, through mechanically stable interlayer PEDOT-polystyrene sulfonate...
Abstract PEDOT (Poly(3,4‐ethylenedioxythiophene)) is one of the most promising electrode materials for biomedical applications like neural recording and stimulation, thanks to its enhanced biocompatibility electronic properties. Drug delivery by typically achieved incorporating drugs as dopants during electrodeposition procedure a subsequent release can be promoted applying cathodic trigger that reduces while enabling drug diffuse. This approach has several disadvantages including, instance,...
High-density surface microelectrodes for electrocorticography (ECoG) have become more common in recent years recording electrical signals from the cortex. With an acceptable invasiveness/signal fidelity trade-off and high spatial resolution, micro-ECoG is a promising tool to resolve fine task-related spatial-temporal dynamics. However, volume conduction - not negligible phenomenon likely frustrate efforts obtain reliable resolved sub-millimeter electrode array. To address this issue, we...
Abstract Implantable electrodes are one of the most common tools in electrophysiology research, both for acute recording intracortical signals and chronical experiments. A stable low‐impedance electrode to tissue interface is fundamental obtain reliable, long term recordings central nervous system activity. Commonly used metal do not fully meet such requirements, as their surface often degrades time they have high impedance. Nanostructured coatings, platinum black past more recently...