A5068434925- Plant Molecular Biology Research
- Plant Reproductive Biology
- Genomics and Chromatin Dynamics
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Immune cells in cancer
- Polysaccharides and Plant Cell Walls
- Immune Cell Function and Interaction
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2020-2023
Growing tumors avoid recognition and destruction by the immune system. During continuous stimulation of tumor-infiltrating lymphocytes (TILs) tumors, TILs become functionally exhausted; thus, they unable to kill tumor cells produce certain cytokines lose their ability proliferate. This collectively results in escape cancer cells. Here, we show that breast expressing PD-L1 can accelerate exhaustion persistently activated human effector CD4+ T cells, manifesting high PD-1 expression level son...
SWI/SNF ATP-dependent chromatin remodeling complexes (CRCs) play important roles in the regulation of transcription, cell cycle, DNA replication, repair, and hormone signaling eukaryotes. The core CRCs composed a SWI2/SNF2 type ATPase, SNF5 two SWI3 subunits is sufficient for execution nucleosome vitro. Arabidopsis genome encodes four ATPases, SWI3, single SWP73 subunits. Genes components have critical but not fully overlapping during plant growth, embryogenesis, sporophyte development. Here...
The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs) comprising (ER), ERECTA-LIKE 1 (ERL1), and 2 (ERL2) controls epidermal patterning, inflorescence architecture, stomata development patterning. These proteins are reported to be plasma membrane associated. Here we show that the er/erl1/erl2 mutant exhibits impaired gibberellin (GA) biosynthesis perception alongside broad transcriptional changes. ERf kinase domains were found localize nucleus where they...
Abstract The Arabidopsis ERECTA family (ERf) of leucine-rich repeat receptor-like kinases (LRR-RLKs), comprising (ER), ERECTA-LIKE 1 (ERL1) and 2 (ERL2), control epidermal patterning, inflorescence architecture, stomata development, hormonal signaling. Here we show that the er/erl1/erl2 triple mutant exhibits impaired gibberellin (GA) biosynthesis perception alongside broad transcriptional changes. ERf proteins interact in nucleus, via kinase domains, with SWI3B subunit SWI/SNF chromatin...