A5046414260- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuropeptides and Animal Physiology
- Extracellular vesicles in disease
- Cardiovascular and exercise physiology
- Eicosanoids and Hypertension Pharmacology
- Stress Responses and Cortisol
- Sphingolipid Metabolism and Signaling
- Gut microbiota and health
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Lipid Membrane Structure and Behavior
- Probiotics and Fermented Foods
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- Mechanical Circulatory Support Devices
- High Altitude and Hypoxia
- Fatty Acid Research and Health
- Muscle activation and electromyography studies
- Protein Hydrolysis and Bioactive Peptides
- Tryptophan and brain disorders
Georgia State University
2025
Tufts University
2023-2024
Auburn University
2016-2023
Center for Neurosciences
2021
Angiotensin II (AngII) is implicated in neuroinflammation, blood-brain barrier (BBB) disruption, and autonomic dysfunction hypertension. We have previously shown that exogenous AngII stimulates Toll-like receptor 4 (TLR4) via type 1 (AT1R), inducing activation of hypothalamic microglia ex vivo, AngII-AT1R signaling necessary for the loss BBB integrity spontaneously hypertensive rats (SHRs). Herein, we hypothesized microglial TLR4 AT1R interactions represent a crucial mechanistic link between...
Relief from psychological stress confers cardio-protection by altering brain activity and lowering blood pressure; however, the neuronal circuits orchestrating these effects are unknown. Here, we used male mice to discern conferring relief reduced pressure. We found that neurons residing in central nucleus of amygdala (CeA) expressing angiotensin type 2 receptors (AT R), deemed CeA AT2R , innervate nuclei regulating responding. In vivo optogenetic excitation lowered pressure this effect was...
Female biased pathology and cognitive decline in Alzheimer's disease (AD) have been consistently observed with unclear underlying mechanisms. Although brain sphingolipid ceramide is elevated AD patients, whether how may contribute to sex-specific differences amyloid unknown. Here we investigated the impact of chronic pharmacological inhibition neutral sphingomyelinase (nSMase), a key enzyme responsible for metabolism, on vivo neuron-derived exosome dynamics, Aβ plaque load, function...
Alzheimer's disease (AD) is characterized by the presence of two hallmark pathologies: accumulation Amyloid beta (Aβ) and tau proteins in brain. There a growing body evidence suggesting that astrocytes, type glial cell brain, play crucial roles clearing Aβ binding to proteins. However, due heterogeneity specific different astrocyte subpopulations response remain unclear. To enhance understanding AD, we investigated lineage cells based on single-nuclei transcriptomic data obtained from both...
The mechanisms by which changes in intracranial pressure (ICP) occur during hypertension are unclear. experimental 2K1C (2-kidney, 1-clip) is a model characterized sympathetic and renin-angiotensin system overactivation ICP still needs investigation. In the present study, we analyzed alterations development of using invasive noninvasive recording methods. We also tested importance AT1R (angiotensin II type 1 receptor) activation for investigated integrity blood-brain barrier within central...
Neurogenic hypertension is characterized by heightened sympathetic drive to the cardiovascular system from key brain regions, including hypothalamic paraventricular nucleus (PVN). Dysregulation of Angiotensin II (AngII) during linked elevated synthesis pro‐inflammatory cytokines in PVN, suggesting a role for AngII modulating sympathoexcitation through neuroinflammation. We have recently shown functional interaction between type‐I receptor (AT1r) and Toll‐like 4 (TLR4) mediating...
Angiotensin II (AngII) plays a primary role in the pathophysiology of hypertension, directly influencing glia and neurons through its type I receptor (AT1R) within central cardioregulatory nuclei. Yet, exact cell type‐specific signaling pathway(s) by which AngII contributes to hypertensive state are unclear. We hypothesized that impairs cellular antioxidant defense systems via Nrf2 (nuclear factor erythroid 2‐related 2) dysregulation, resulting astrogliosis contributing neuroinflammation....
Previous efforts to define the mechanisms underlying neurogenic hypertension implicate angiotensin II (AngII) as a critical force behind blood‐brain barrier (BBB) disruption observed in this pathology. We have further shown that exposure of hypothalamic microglia AngII stimulates Toll‐like receptor 4 (TLR4) via type 1 (AT1R), resulting microglial activation. propose abnormal AngII‐mediated activation through AT1R‐TLR4 crosstalk drives vicious feed‐forward loop comprised BBB disruption,...
Oxidative stress is a central mechanism underlying Angiotensin II (AngII)-induced enhanced sympathetic outflow within brain cardio-regulatory nuclei in neurogenic hypertension. Yet, causal association between AngII, Nrf2 (nuclear factor erythroid 2-related 2 - the master regulator of antioxidant response), and activity hypertension has not been explored. We hypothesized that increased AngII impairs signaling pathway paraventricular nucleus hypothalamus (PVN), leading to oxidative stress,...
PURPOSE Factors influencing maintenance of force development (i.e., fatigue) remain incompletely understood. Previous research in the perfused canine gastrocnemius‐superficial digital flexor muscle complex (GS) (e.g., Barclay. J Appl Physiol 61(3):1084–90, 1986) has suggested that higher blood flow, independent O 2 delivery diminishes fatigue rate. The aim this investigation was to evaluate skeletal at two different metabolic rates GS while flow varied but held constant. METHODS Canine...
Abstract Background Altered ceramide metabolism is implicated in Alzheimer’s disease (AD) progression. Although prior work shows that inhibition of neutral sphingomyelinase (nSMase) 2, a key enzyme responsible for hydrolysis sphingomyelin to ceramide, reduces exosome secretion, attenuates Aβ pathology, and improves cognitive function, these studies have been limited vitro application or short‐term treatments fast‐progressing models. Method We employed the slow‐progressing APP NL‐F/NL‐F...
Introduction Previous studies have shown a decreased muscle oxygen consumption (V′O 2 ) during moderate intensity exercise in hypoxia after augmented nitric oxide (NO) bioavailability, which suggests an increased efficiency of oxidative metabolism. It is not clear if these effects are related to NO‐induced increase convective O delivery and/or enhanced mitochondrial coupling efficiency. The aim this study was examine skeletal contraction economy hypoxic following nitrite infusion with...
Gut microbiota dysbiosis has been associated with hypertension. Long‐term use of probiotics have shown to decrease blood pressure, improve baroreflex, and ameliorate endothelial dysfunction in Spontaneously Hypertensive Rats (SHR). Yet, the mechanisms are not well understood. We aimed evaluate peripheral centrally mediated by which probiotic kefir promotes beneficial effects SHRs. used Wistar Kyoto (WKY) SHR male rats, divided into: WKY treated vehicle, milk fermented grains (5%; SHR‐Kefir;...
Hypertension is linked to blood-brain barrier (BBB) disruption and neuroinflammation in areas such as the hypothalamic paraventricular nucleus (PVN) rostral ventrolateral medulla (RVLM). We have shown that Angiotensin II (AngII) induces BBB breakdown via type 1 receptors (AT1r) activates microglia ex vivo through AT1r Toll-like receptor 4 (TLR4). hypothesized TLR4 activation a key contributor AngII-mediated disruption, neuroinflammation, autonomic dysfunction. Spontaneously hypertensive rats...