A5017453315- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Renal and Vascular Pathologies
- Bladder and Urothelial Cancer Treatments
- Organ Donation and Transplantation
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Adrenal and Paraganglionic Tumors
- Organ Transplantation Techniques and Outcomes
- Ureteral procedures and complications
- Renal cell carcinoma treatment
- Kidney Stones and Urolithiasis Treatments
- Cell Adhesion Molecules Research
- Hormonal and reproductive studies
- Pituitary Gland Disorders and Treatments
- Sexual function and dysfunction studies
- Urologic and reproductive health conditions
- Monoclonal and Polyclonal Antibodies Research
- Nitric Oxide and Endothelin Effects
- Thyroid Disorders and Treatments
Showa University Fujigaoka Hospital
2014-2016
Ito Hospital
2009-2014
Showa University
2004-2012
Tokyo Women's Medical University
2004
Niigata University
1981-1996
Nagaoka Red Cross Hospital
1993
From January 17, 1992 to 16, 1993, laparoscopic adrenalectomy was performed in 7 patients (3 men, 4 women) with primary aldosteronism ranging age from 35 65 years (mean 48.7 years). Five of the adrenal lesions were on left side and two right. six trocar-sheath units used, tumors successfully removed adjacent normal glands all patients. The operative time ranged 165 572 min 302 min), blood loss between 50 450 ml 217.2 ml), there no major complication. In conclusion, is a safe alternative...
Abstract In this study we examined the expression of intercellular adhesion molecule‐1 (ICAM‐I) in 28 cases renal‐cell cancer (RCC). We also ICAM‐I on RCC cell lines response to cytokines. Immunohistochemistry revealed frequent (23 positive among RCCs) RCC. The molecule was not detected renal tubular cells as far could be determined. Furthermore, number ICAM‐I‐positive significantly correlated with degree mononuclear infiltration, involving mainly T lymphocytes and a smaller macrophages...
The clinical characteristics of myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis caused by antithyroid drugs are still unclear because most reports describe only a small number patients.The objective was to analyze large patients with MPO-ANCA-associated determine the time onset, drug and dose taken, symptoms, relationship between symptoms MPO-ANCA titer, incidence.We analyzed 92 in whom adverse reaction reported Chugai Pharmaceutical, company that markets...
Thyroid ultrasonography (US) is the most sensitive method for detecting thyroid nodules, and US-guided aspiration biopsy accurate diagnostic procedure nodules. We performed this retrospective study to establish prevalence of nodules in Graves' disease patients with Hashimoto's thyroiditis at time their initial visit.We US as routine screening 1652 2036 fine-needle when diameter a nodule >1 cm or was suspected being malignant.The papillary carcinoma higher than (1.77% vs. 0.97%), two (0.098%)...
Background: Methimazole (MMI) is usually used at an initial dose of 30 mg/day for severe Graves' disease (GD) hyperthyroidism, but adverse effects are more frequent this than MMI 15 mg/day. Objectives: We designed a regimen to address the lack primary therapeutic effect by combining it with inorganic iodine 38.2 Our aim was compare two regimens (MMI mg+inorganic (M15+I) vs. (M30)) in terms effect, effects, and remission rate. Design Patients: In prospective study, 310 patients untreated GD...
Abstract Hic‐5 is a LIM protein with striking similarity to paxillin, and shuttles between focal adhesions the nucleus. Our previous study suggested that participates in transcriptional control of several genes such as c‐ fos p21 genes. In present study, we examined function nucleus using promoter region gene. When localized nucleus, was found transactivate through two five Sp1 sites proximal TATA box. The effect mediated by transactivation domain functional interaction p300 LIM4 domain....
Abstract Very late antigen‐4 (VLA‐4) composed of α and β, a member the β ‐integrin subfamily, facilitates cell‐to‐cell interaction with vascular celladhesion molecule‐1 (VCAM‐1) on endothelial cells (EC). Attachment bloodborne tumor to EC is crucial step for hematogenous metastasis, VLA‐4‐positive can attach by binding VCAM‐1. Renalcell cancer (RCC) reveals proportionally greater percentages metastases than other carcinomas at initial diagnosis. We investigated whether VLA‐4 expressed RCC,...
No AccessJournal of Urology1 Mar 1993Immunohistochemical Detection Intercellular Adhesion Molecule-1 (ICAM-1) and Major Histocompatibility Complex Class I Antigens in Seminoma Yoshihiko Tomita, Motohiko Kimura, Toshiki Tanikawa, Tsutomu Nishiyama, Hideo Morishita, Masayuki Takeda, Michio Fujiwara, Shotaro Sato TomitaYoshihiko Tomita More articles by this author , KimuraMotohiko Kimura TanikawaToshiki Tanikawa NishiyamaTsutomu Nishiyama MorishitaHideo Morishita TakedaMasayuki Takeda...
The p53 gene product has been detected frequently in various human malignancies. We have studied the expression of protein urothelial transitional cell cancers (TCCs) and examined its correlation with pathologic grade, stage(pT) patient survival. Specimens from 69 surgically-resected TCCs (38 cases urinary bladder cancer, 17 ureteral cancer 14 renal pelvic cancer) were by immunohistochemical staining, using two anti-p53 monoclonal antibodies, PAb1801 PAb240, a polyclonal antibody, CM-1....
Abstract Extrathymic generation of T cells in the liver and intestine was recently demonstrated. We investigated herein whether such cells, especially those liver, are present other organs mice. This investigation is possible employing our introduced method with which even a minor proportion extrathymic, intermediate TCR than can be identified. Intermediate expressed higher levels IL‐2Rβ LFA‐1 bright (i.e., thymic origin) as revealed by two‐color staining. Although were at small spleen...
The patient was a 61-year-old woman who had well-differentiated pancreatic neuroendocrine tumor (PNET) with lymph node metastasis. After 15 months of octreotide treatment, glucose control deteriorated and pigmentation the tongue moon face developed, leading to diagnosis ectopic adrenocorticotropic hormone (ACTH) syndrome. An abnormal secretion growth (GH) identified, plasma hormone-releasing (GHRH) level elevated. A biopsy specimen positively immunostained for ACTH GHRH. Ectopic seems have...
We report a case of primary localized amyloidosis the bladder with amyloid deposits which was characterized as being immunoglobulin light chain origin (AL) including Λ type (A Λ) and P component (AP) using KMnO4 pre-treatment method immunohistochemical procedures. The patient treated successfully intravesical dimethyl sulfoxide instillation oral administration high-dose cepharanthin after transurethral resection. Combination therapy shown to be useful for bladder.
A pressure-flow study of the corpus cavernosum penis in dog was performed during flaccid, tumescent, erect and rigid stages. Perfusion selectively made into penile deep artery. The stage induced with local administration papaverine hydrochloride, by electrostimulation ischiocavernous muscle stage. Concurrently, vascular casts at each erection were observed under a scanning electron microscope for anatomical analysis mechanisms controlling cavernous pressure. In study, it demonstrated that...
To visualize the entire shape of intraepithelial nerve fibers, whole mount preparations dog urethra were produced and immunostained with an antiserum against CGRP, one predominant substances contained in nerves.The immunoreactive nerves lamina propria smooth (non-beaded) appearance weak immunoreaction. Within epithelium, they displayed typical beaded profiles intense The fibers branched wound into extensive network wide meshes (“reticular terminal”). bead-like swellings included large ones...