A5069364660- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Sirtuins and Resveratrol in Medicine
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Nitric Oxide and Endothelin Effects
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Aortic aneurysm repair treatments
- Cardiac Arrest and Resuscitation
- Signaling Pathways in Disease
- Neuropeptides and Animal Physiology
- Inflammatory mediators and NSAID effects
- Congenital Heart Disease Studies
- Surgical Simulation and Training
- Acute Myocardial Infarction Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2023-2025
Tufts University
2021-2024
Johns Hopkins Hospital
2023-2024
Tufts Medical Center
2021-2023
Maine Medical Center
2016-2022
University Medical Center
2021-2022
Tenwek Hospital
2022
Maine Medical Center
2018-2022
Boston University
2021
Objective: We investigate the impact of different regimens parenteral hydrogen sulfide (H2S) administration on myocardium during ischemia-reperfusion (IR) and molecular pathways involved in its cytoprotective effects. Methods: Eighteen male Yorkshire pigs underwent 60 minutes mid-left anterior descending coronary artery occlusion followed by 120 reperfusion. Pigs received either placebo (control, n = 6) or H2S as a bolus (bolus group, 6, 0.2 mg/kg over 10 seconds at start reperfusion) an...
Background— Resveratrol may provide protection against coronary artery disease. We hypothesized that supplemental resveratrol will improve cardiac perfusion in the ischemic territory of swine with hypercholesterolemia and chronic myocardial ischemia. Methods Results— Yorkshire were fed either a normal diet (control, n=7), hypercholesterolemic (HCC, or (100 mg/kg/d orally, HCRV, n=7). Four weeks later, an ameroid constrictor was placed on left circumflex artery. Animals underwent MRI...
Intramyocardialhemorrhage (IMH) reflects severe reperfusion injury in acute myocardial infarction. Non-invasive detection of IMH by cardiovascular magnetic resonance (CMR) may serve as a surrogate marker to evaluate the effect preventive measures reduce and hence provide additional prognostic information. We sought investigate whether could be detected CMR exploiting T1 shortening methemoglobin an experimental model The results were compared T2-weighthed short tau inversion recovery...
Background We sought to determine whether publication of blood conservation guidelines by the S ociety T horacic urgeons in 2007 influenced transfusion rates and understand how patient‐ hospital‐level factors product usage. Study Design Methods identified 4,465,016 patients N ationwide I npatient ample database who underwent cardiac operations between 1999 2010 (3,202,404 before 1,262,612 after). Hierarchical linear modeling was used account for hospital‐ patient‐level clustering. Results...
Gastrointestinal complications after cardiac surgery are relatively rare entities but carry a high mortality. We identified over 70 articles written since 2010 using the PubMed database. included 40 in our review. The most common include paralytic ileus, gastrointestinal bleeding, and bowel ischemia. Patients who undergo procedures at risk for poor perfusion of tract and, thus, resulting complications. Risk factors these peri-operative use vasopressors, prolonged operative time, time...
Background— Hypercholesterolemia is prevalent in patients who experience myocardial ischemia-reperfusion injury (IR). We investigate the impact of dietary-induced hypercholesterolemia on myocardium setting acute IR. Methods and Results— In normocholesterolemic (NC, n=7) hypercholesterolemic (HC, Yucatan male pigs, left anterior descending coronary artery was occluded for 60 minutes, followed by reperfusion 120 minutes. Hemodynamic values were recorded, TTC staining used to assess necrosis....
Introduction The need for permanent pacemaker implantation (PCM) following surgical aortic valve replacement (SAVR) is uncommon but can lead to increased hospital resource utilization. Using nationwide data, we sought (1) identify hospital, patient, and procedure-level risk factors PCM after SAVR (2) determine incremental Methods We identified 659,692 patients from the Nationwide Inpatient Sample database who underwent with or without coronary artery bypass grafting (CABG), mitral...
BACKGROUND: Prior studies identified thresholds for mean arterial pressure (MAP <65 mm Hg) and central venous (CVP >12 beyond which risk cardiac surgery-associated acute kidney injury (AKI) increases. Optimal hemodynamic targets—that is, where active protection from AKI is observed—are unclear; however, current guidelines suggest maintaining MAP >65 CVP 8 to 12. The aim of this study was identify ranges associated with both increased decreased by evaluating narrow MAP, CVP, joint...
We investigated the impact of hydrogen sulfide (H2S) on myocardium in setting cold crystalloid cardioplegia and cardiopulmonary bypass (CP/CPB). Eighteen male Yorkshire pigs underwent 1 h CP/CPB followed by 2 reperfusion. Pigs received either: placebo (control, n=9), or H2S (as NaHS) as a bolus/infusion (bolus/infusion, n=6), an infusion (infusion, n=6). The expression pattern various myocardial effector pathways was investigated. Coronary microvascular relaxation to endothelium-dependent...