A5091158444- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Sirtuins and Resveratrol in Medicine
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Surgical site infection prevention
- Cardiac Fibrosis and Remodeling
- Reconstructive Surgery and Microvascular Techniques
- Cardiac Arrest and Resuscitation
- Pleural and Pulmonary Diseases
- Calpain Protease Function and Regulation
- Neuropeptides and Animal Physiology
- Congenital heart defects research
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
Beth Israel Deaconess Medical Center
2011-2024
Harvard University
2011-2024
Creative Commons
2022
Novem (Netherlands)
2020
Massachusetts General Hospital
2020
Brigham and Women's Hospital
2020
Deaconess Hospital
2018
Brown University
2010-2017
Lifespan
2017
Cardiovascular Research Center
2013
Chymase is activated after acute myocardial ischemia/reperfusion (AMI-R) and associated with an early activation of matrix metalloproteinase-9 (MMP-9), which increases infarct size experimental AMI, late fibrosis. We assessed the effect chymase inhibition on protection signs fibrosis AMI-R. Fourteen pigs underwent AMI-R received intravenously either vehicle (V; <i>n</i> = 7) or inhibitor (CM; 7). Separately, rat fibroblast was incubated (<i>n</i> 4), low-dose high-dose plus 4). Infarct (V,...
Background Despite evidence suggesting detrimental effects of perioperative hyperoxia, hyperoxygenation remains commonplace in cardiac surgery. Hyperoxygenation may increase oxidative damage and neuronal injury leading to potential differences postoperative neurocognition. Therefore, this study tested the primary hypothesis that intraoperative normoxia, as compared reduces cognitive dysfunction older patients having Methods A randomized double-blind trial was conducted aged 65 yr or coronary...
Background— We investigated the effects of cardiopulmonary bypass (CPB) on peripheral arteriolar reactivity and associated signaling pathways in poorly controlled (UDM), (CDM), case-matched nondiabetic (ND) patients undergoing coronary artery grafting (CABG). Methods Results— Skeletal muscle arterioles were harvested before after CPB from UDM (hemoglobin A1c [HbA1c]=9.0±0.3), CDM (HbA1c=6.3±0.15), ND (HbA1c=5.2±0.1) CABG surgery (n=10/group). In vitro relaxation responses precontracted to...
Appreciation of unique presentation, patterns and underlying pathophysiology coronary artery disease in women has driven gender based risk stratification reduction efforts over the last decade. Data regarding whether these advances have resulted unequivocal improvements outcomes CABG is conflicting. The objective our study was to assess differences post-operative following CABG.Retrospective analyses institutional data housed Society Thoracic Surgeons (STS) database for patients undergoing...
Moderate consumption of alcohol, particularly red wine, has been shown to decrease cardiac risk. We used a hypercholesterolemic swine model chronic ischemia examine the effects 2 alcoholic beverages on heart. Yorkshire fed high-cholesterol diet underwent left circumflex ameroid constrictor placement induce at 8 weeks age. One group (HCC, n=9) continued alone, second (HCW, n=8) was supplemented with wine (pinot noir, 12.5% 375 mL daily), and third (HCV, vodka (40% 112 daily). After 7 weeks,...