A5073436447- RNA Research and Splicing
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- SARS-CoV-2 detection and testing
- CRISPR and Genetic Engineering
- Neurogenetic and Muscular Disorders Research
Centre for Genomic Regulation
2020-2024
Universitat Pompeu Fabra
2021-2024
Institute of Science and Technology
2020
The regulation of pre-mRNA processing has important consequences for cell division and the control cancer proliferation, but underlying molecular mechanisms remain poorly understood. We report that three splicing factors, SPF45, SR140, CHERP, form a tight physical functionally coherent complex regulates variety alternative events, frequently by repressing short exons flanked suboptimal 3′ splice sites. These comprise embedded in genes with functions cell-cycle progression, including G2/M key...
The COVID-19 pandemic has posed and is continuously posing enormous societal health challenges worldwide. research community mobilized to develop novel projects find a cure or vaccine, as well contribute mass testing, which been critical measure contain the infection in several countries. Through this article, we share our experiences learnings group of volunteers at Centre for Genomic Regulation (CRG) Barcelona, Spain. As members ORFEU project, an initiative by Government Catalonia achieve...