A5074382441- Viral gastroenteritis research and epidemiology
- Transgenic Plants and Applications
- Toxin Mechanisms and Immunotoxins
- Clostridium difficile and Clostridium perfringens research
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Liver Disease and Transplantation
- interferon and immune responses
- Gut microbiota and health
- RNA Interference and Gene Delivery
- Bacteriophages and microbial interactions
- Diabetic Foot Ulcer Assessment and Management
- Silk-based biomaterials and applications
- Organ Transplantation Techniques and Outcomes
- Antimicrobial Peptides and Activities
- Salmonella and Campylobacter epidemiology
Arizona State University
2018-2020
Necrotic enteritis is an economically important poultry disease caused by the bacterium Clostridium perfringens. There are currently no necrotic vaccines commercially available for use in broiler birds, most target population. Salmonella-vectored represent a convenient and effective option controlling this disease. We used single attenuated Salmonella vaccine strain, engineered to lyse within host, deliver up three C. perfringens antigens. Two of antigens were toxoids, based on α-toxin NetB...
Numerous treatments have been developed to promote wound healing based on current understandings of the process. Hemorrhaging, clotting, and associated inflammation regulate early healing. We investigated treatment with a virus-derived immune modulating serine protease inhibitor (SERPIN), Serp-1, which inhibits thrombolytic proteases inflammation, in mouse excisional model. Saline or recombinant Serp-1 were applied directly wounds as single doses 1 μg 2 µg two boluses. A chitosan-collagen...
Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is gammaherpesvirus model for producing severe vasculitis, colitis lethal hemorrhagic pneumonia interferon gamma receptor-deficient (IFNγR-/-) mice. In prior work, myxomavirus-derived Serp-1 or derivative peptide S-7 (G305TTASSDTAITLIPR319) induced immune...
Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens. Total global economic losses to poultry industry due NE estimated be over two billion dollars annually. Traditionally, has been effectively controlled inclusion antibiotics in diet poultry. However, recent concerns regarding impact this practice on increasing antibiotic resistance human pathogens have led us consider alternative approaches, such as vaccination, for controlling disease. C....
Ischemia-reperfusion injury (IRI) is an antigen-independent, innate immune response to arterial occlusion and ischemia with subsequent paradoxical exacerbation after reperfusion. IRI remains a critical problem vessel infarction or during harvest surgery in transplants. After transplant, liver (LIRI) contributes increased acute chronic rejection graft loss. Tissue loss LIRI has been attributed local macrophage activation invasion excessive inflammation together hepatocyte apoptosis necrosis....
Necrotic enteritis is an economically important poultry disease caused by the bacterium Clostridium perfringens. There are currently no necrotic vaccines available for use in broiler birds, most target population. Salmonella-vectored represent a convenient and effective option controlling this disease. We used single attenuated Salmonella vaccine strain, engineered to lyse within host, deliver up three C. perfringens antigens. Two of antigens were toxoids, based on ?-toxin NetB toxin. The...
Background . Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens Total global economic losses to poultry industry due NE estimated be over 2 billion dollars annually. Traditionally, has been effectively controlled inclusion antibiotics in diet poultry. However, recent concerns regarding impact this practice on increasing antibiotic resistance human pathogens have led us consider alternative approaches, such as vaccination, for controlling disease. C....
Background . Necrotic enteritis (NE) is caused by type A strains of the bacterium Clostridium perfringens Total global economic losses to poultry industry due NE estimated be over 2 billion dollars annually. Traditionally, has been effectively controlled inclusion antibiotics in diet poultry. However, recent concerns regarding impact this practice on increasing antibiotic resistance human pathogens have led us consider alternative approaches, such as vaccination, for controlling disease. C....