A5058173008- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Complementary and Alternative Medicine Studies
- Cutaneous lymphoproliferative disorders research
- Ocular Surface and Contact Lens
- Health Systems, Economic Evaluations, Quality of Life
- Asthma and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Autoimmune and Inflammatory Disorders Research
- Skin Diseases and Diabetes
- Sympathectomy and Hyperhidrosis Treatments
- Dermatological and Skeletal Disorders
- Antifungal resistance and susceptibility
- Allergic Rhinitis and Sensitization
- Bee Products Chemical Analysis
- Body Contouring and Surgery
- Pharmaceutical studies and practices
- Ginseng Biological Effects and Applications
- melanin and skin pigmentation
- Diabetes and associated disorders
- Vitamin D Research Studies
- Dermatologic Treatments and Research
- PI3K/AKT/mTOR signaling in cancer
- Inflammatory mediators and NSAID effects
Cairo University
2016-2025
Identification of epidemiologic and phenotypic variations psoriasis among different ethnic groups can further our understanding this perplexing disease, aiming at better management patients worldwide.To provide a descriptive analysis registered Kasr Al-Ainy Psoriasis Unit Disease Registry.This retrospective single-center registry study included patient records between November 2015 2018 (2534 patients). Sociodemographic data were analyzed.The mean age the was 39.3 years 56.3% men. Stress...
Psoriasis is a persistent inflammatory skin disorder driven by T cells. The disease characterized aberrant keratinocytes (KCs) differentiation, epidermal proliferation, and excessive hyperplasia of veins arteries. purpose the study was to identify levels circulating lnc-HULC, miR-122, Sirtuin 1 (SIRT-1) in psoriatic patients, evaluate their possible roles as diagnostic biomarkers, link with development metabolic syndrome during psoriasis progression. This included 176 participants. subjects...
Abstract Background and Objective New improved treatment modalities, including lasers energy‐based devices, are promising options for hypertrophic scars. This study aimed to assess the efficacy safety of fractional microneedle radiofrequency (FMR) compared with carbon dioxide (CO 2 ) laser in postburn Patients Methods Twenty patients scars were enrolled study. Two areas each patient randomly assigned CO or FMR. Four sessions, 6–8 weeks apart performed. The Patient Observer Scar Assessment...
<b><i>Background:</i></b> Janus kinases (JAKs) are a family of non-receptor protein tyrosine that expressed in variety tissues. Several JAK-controlled cytokine receptor pathways incriminated the initiation and progression psoriasis. Genetic polymorphisms influencing JAK expression would be anticipated to have great impact on disease activity. <b><i>Objective:</i></b> The aim study was evaluate association between <i>JAK1</i>...
To evaluate the retinal vasculature in psoriasis patients and detect if metabolic syndrome is an additional risk factor. This cross-sectional analytic study was carried out on 80 eyes of subjects; 28 with only (PS group), 12 to (PMS group) 40 healthy controls (HS). The capillary plexuses were evaluated by OCTA. disease activity Psoriasis Area Severity Index (PASI) score extent. superficial plexus (SCP) vascular density significantly lower PS group than HS while PMS it whole image superior...
Abstract Background Misconceptions among psoriatic patients often lead to a negative impact on disease outcomes. Objectives Our main target was knowledge assessment sample of in the Middle East and North Africa (MENA) region where data are scarce. Methods The present study is cross‐sectional descriptive survey. It consists an online questionnaire comprising 19 questions designed assess psoriasis five demographic questions. link posted official Facebook page Kasr Al Ainy Psoriasis Unit...
Cyclooxygenase-2 (COX-2) is an inducible modulator of inflammation that acts through increasing prostaglandin levels and has been described as a major mediator linking to cancer. Previous studies supported COX-2-765G>C -1195A>G polymorphisms were associated with increased risk several solid tissue cancers well some hematological malignancies.The aim the study was elucidate association between functional COX-2 genotypes (-765G>C -1195A>G) developing mycosis fungoides (MF).This hospital-based,...
Growing evidence suggests the important role of IL-36 in pathogenesis psoriasis. Cathepsin G is a neutrophil-derived protease that can activate IL-36γ.To assess expression IL-36γ and cathepsin psoriasis to quantify impact treatment with narrow-band ultraviolet B phototherapy (NB-UVB) on their levels.This case-control study involved 26 patients moderate-severe 25 healthy volunteers. Psoriasis eligible for received 24 NB-UVB sessions. Punch skin biopsies were obtained from all participants at...
Psoriasis is a chronic multisystem inflammatory disease affecting primarily the skin and joints but also involves several comorbidities. The affects between 0.2 4% of population worldwide. Kasr Al-Ainy Unit developed protocol therapy for psoriasis. Part I discussed topical systemic therapies. This part discusses biological therapy. Biological therapies psoriasis are agents that can specifically target an immune mediator block specific molecular steps important in pathogenesis Despite cost,...
Psoriasis is a chronic multisystem inflammatory disease affecting primarily the skin and joints also involves several comorbidities. The affects between 0.2 4% of population worldwide. approach to patient its proper management needs holistic approach, where physician treats not just plaques psoriasis. Kasr Al-Ainy Unit developed protocol therapy for psoriasis, based on best available scientific evidence expert opinion team, taking into consideration regional characteristics our patients...
Signal transducer and activator of transcription (STAT)-3 belongs to a group latent factors phosphorylated activated by several protein tyrosine kinases, including members Janus kinases (JAKs) family. It has been implicated that the JAK-STAT pathway activation could promote quiescence in hair cycle, topical treatment mouse human skin with JAK inhibitors was shown result rapid growth.Our aim assess tissue expression STAT3 patients androgenetic alopecia correlate it disease severity clinical...
Department of Dermatology, Kasr Alainy Hospital, Faculty Medicine, Cairo University, Giza, Egypt. Correspondence: Yousra Azzazi, MD, Giza 41516, Egypt (e-mail: [email protected]). The authors declare no conflicts interest.
Background Psoriasis is an immune-mediated systemic inflammatory disease in which corneal affection takes various forms such as dry eye (DED), punctate epithelial keratitis, and sterile infiltrates. Purpose The aim of this study was to evaluate the profile psoriasis patients using anterior segment optical coherence tomography (AS-OCT). Patients methods This a cross-sectional analytic that included 81 eyes: 39 eyes 20 42 21 healthy age-matched sex-matched controls. They were divided into...