Evaluation of serum ferritin and vitamin D levels in females with chronic telogen effluvium (TE) or female pattern hair loss (FPHL), order to validate their role these common diseases.Eighty (18 45 years old) loss, the form TE FPHL, 40 age-matched no were included study. Diagnosis was based upon clinical examination as well trichogram dermoscopy. Serum D2 determined for each participant.Serum (14.7 ± 22.1 μg/l) FPHL (23.9 38.5 candidates significantly lower than controls (43.5 20.4 μg/l)....

Summary Intralesional ( IL ) corticosteroid therapy is a treatment for keloids. botulinum toxin type A BTA has been postulated in such an indication with controversial reports. To compare efficacy and safety of to the Twenty‐four patients keloids were randomly divided into two equal groups: receiving steroid repeated every 4 weeks six sessions (group A) 5 IU /cm 3 8 three B). Objective parameters (hardness, elevation, redness), subjective complaints (itching, pain, tenderness), patient...

Patients with dystrophic epidermolysis bullosa (DEB) have mutations in type VII collagen gene. Type is synthesized by keratinocytes and fibroblasts. Based on the ability of bone marrow non-hematopoeitic stem cells (NHBMSC) to develop into fibroblasts, we decided investigate use NHBMSC treatment recessive DEB (RDEB). This study included fourteen patients RDEB; first seven them were given cyclosporine after infusion NHBMSC. As has been used for RDEB not second group patients. Skin biopsies...

Female pattern hair loss (FPHL) is the most common form of in women. Nevertheless, its management represents a real challenge. Among FDA approved therapeutic modalities for FPHL are topical minoxidil and more recently low-level light therapy (LLLT).Assess efficacy safety LLLT comparison to 5% combination both therapies treatment FPHL.This study included 45 female patients with proven FPHL. They were randomly divided into three equal groups, where group (i) instructed apply twice daily, (ii)...

Percutaneous collagen induction (PCI) promotes removal of damaged and induces more immediately under the epidermis. The chemical reconstruction skin scars (CROSS) method is a focal application full-concentration trichloroacetic acid (TCA) to atrophic acne scars. CROSS has advantage reconstructing by increasing dermal thickening production.To compare safety efficacy PCI 100% TCA for treatment scars.Thirty participants were randomly equally divided into two groups; group 1 underwent four...

Psoriasis is a disorder with genetic and immunologic background. Leptin can regulate the T-helper response.Our primary goal to study functional polymorphism (G-2548A) of leptin (LEP) gene in predisposition psoriasis, our secondary examine factors affecting plasma levels psoriasis compare patients without metabolic syndrome (MS).The involved 94 100 healthy controls. Analysis G-2548A LEP was made by PCR restriction fragment length technique. The relationship between clinical features analysed....

To investigate the role of paraoxonase 1 (PON1) and vitamin E in pathogenesis some autoimmune diseases, to correlate their levels with disease activity.This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo alopecia areata (AA) 15 each group] healthy controls. Venous blood tissue biopsy were collected subject estimate PON1.All showed significantly lower both PON1 serum than controls (p < 0.001).An association between oxidative stress...

Laser-assisted hair removal causes miniaturization of shafts which are the principal contributors to inflammation in acne keloidalis nuchae (AKN). To assess efficacy reduction by long pulsed Nd-YAG laser as a therapeutic modality for AKN. This interventional pilot trial included 16 patients with AKN who received 5 sessions laser. Lesions were objectively and subjectively assessed at third fifth sessions, 1 year after. Global response treatment was rated using quartile grading scale regarding...

Hypertrophic scars and keloids exhibit high recurrence rates following surgical excision. Intralesional cryosurgery (ILC) can achieve a higher degree of effectiveness than the surface cryotherapy. The aim this study is to assess clinical efficacy ILC using Weshahy cryoneedles followed by IL steroid in trial getting rid fibrous mass destruction, not surgery avoid being under tension new scar. This included 22 patients. Evaluation volume reduction lesions was done after single session...

Pemphigus vulgaris (PV) represents a potentially life-threatening autoimmune blistering disease in which IgG autoantibodies are directed against cell-cell adhesion molecules. Tumour necrosis factor (TNF)-alpha has been suggested to have possible role the mechanism underlying acantholysis.This comparative double-blinded study was carried out estimate use of both sulfasalazine (SSZ) and pentoxifylline (PTX) (low-cost anti-TNF drugs) as an adjuvant therapy for PV.The included 64 patients with...

Deep peeling using phenol and percutaneous collagen induction (PCI) are used in treating acne scars.To compare deep PCI combined with trichloroacetic acid (TCA) 20% atrophic scars.24 patients post-acne scars were randomly divided into two groups; group 1 was subjected to one session of phenol, 2 four sessions TCA 20%. As a secondary outcome measure, side effects recorded asked assess their % improvement by questionnaire completed 8 months after the procedure.Scar severity scores improved...

Introduction The paucity of studies evaluating teledermatology (TD) in developing countries was the impetus behind conducting this work. We aimed to evaluate feasibility and reliability TD remote areas where medical facilities consultant dermatologists are not available, through measurement diagnostic concordance rates between face-to-face diagnosis store-and-forward (SAF) diagnosis. Methods A total 600 patients with dermatological ailments who attended Abshway Hospital were recruited into...

Enlarged facial pores are becoming a matter of cosmetic concern. Injections (botulinum toxin type A) have an increasing popularity among procedures.To determine the efficacy and safety intradermal injection botulinum in treatment excess sebum secretion enlarged pores.This split face-controlled pilot study was conducted on 20 patients with seborrhea. One cheek treated by toxin, other injected saline. Patient assessment performed after 1 then 4 months.At 1-month assessment, both sides showed...

Skin tags (STs), are papillomas commonly found in the neck and axillae of middle-aged elderly people. Metabolic syndrome (MS) is a complex interrelated risk factors for cardiovascular disease diabetes. Epidemiologic studies different ethnic populations have indicated that hyperleptinaemia leptin resistance strongly associated with MS.To study possible relation skin levels to MS guided by International Diabetes Federation (IDF) diagnostic criteria.This included 80 participants, 40 ST patients...

There have been no well-controlled studies evaluating the efficacy of combining 1540 nm nonablative fractional laser with percutaneous collagen induction (PCI) and trichloroacetic acid (TCA) 20% in treatment atrophic acne scars.We hypothesized that combined alternating sessions both modalities would show better results than each individual modality.Thirty-nine patients post scars were included this study. Patients randomly equally divided into three groups; group 1 was subjected to six PCI...

Summary Background Chemical peels and topical depigmenting agents have become a popular modality in the treatment of melasma. Aims To compare clinical efficacy trichloroacetic acid peel 20% vs. Jessner’s solution mixture hydroquinone 2% kojic acid. Patients methods Forty five patients with melasma were randomly assigned into three groups fifteen each. Group A received peel, group B 20%, C All seen follow‐up period after 16 weeks; evaluation using Melasma Area Severity Index (MASI) score...

Background: Combined azelaic acid (AA) and salicylic (SA) have not been previously used for acne. Objective: To compare the efficacy of this combination versus trichloroacetic (TCA) 25% peel in Methods: Thirty-four patients were included trial. Patients received four sessions 2 weeks apart. The combined solution was applied to one side face, while TCA other. Our outcomes physician-reported clinical improvement, dermoscopic assessment erythema patient's satisfaction. Results: After two...

Melasma is a hard-to-manage disorder with considerable relapsing behavior. Dermoscopy emerged to help in comprehensive evaluation of pigmentary disorders and melasma. The aim the study was evaluate potential role dermoscopy assessing melasma monitoring efficacy 1064-nm low-fluence Q-switched neodymium:yttrium-aluminum-garnet (QS Nd:YAG) laser. A total 31 patients facial were included. five laser sessions performed 2-week intervals. Patients evaluated at baseline 2 weeks after last session...

Melasma is a challenging pigmentation disorder.To assess and compare the efficacy of tranexamic acid (TXA) intradermal microinjection alone versus its combination with low-power, low-density fractional CO2 laser in sequential pattern melasma.This study included 29 patients melasma. Half face was randomly assigned to laser; other half TXA. This split-face session repeated every 6 weeks for 3 sessions. In between, TXA applied full 2 weeks. Treatment duration 4 months. Dermoscopy, melanin index...