A5066033447- Psoriasis: Treatment and Pathogenesis
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Hair Growth and Disorders
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Nail Diseases and Treatments
- Acne and Rosacea Treatments and Effects
- Retinoids in leukemia and cellular processes
- Skin Protection and Aging
- Hepatitis C virus research
- Skin and Cellular Biology Research
- RNA regulation and disease
- Autoimmune Bullous Skin Diseases
- T-cell and Retrovirus Studies
- Laser Applications in Dentistry and Medicine
- Mast cells and histamine
- Fungal Infections and Studies
- Liver Disease Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Facial Rejuvenation and Surgery Techniques
- Vascular Tumors and Angiosarcomas
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
Cairo University
2014-2024
Ain Shams University
2024
Advanced Dermatology
2015
Identification of epidemiologic and phenotypic variations psoriasis among different ethnic groups can further our understanding this perplexing disease, aiming at better management patients worldwide.To provide a descriptive analysis registered Kasr Al-Ainy Psoriasis Unit Disease Registry.This retrospective single-center registry study included patient records between November 2015 2018 (2534 patients). Sociodemographic data were analyzed.The mean age the was 39.3 years 56.3% men. Stress...
Abstract Background Data have been accumulating in the past few years that identify vitiligo as a disorder with systemic implications. Results and methods In this hospital‐based, cross‐sectional, case–control study, 50 patients non‐segmental age‐ sex‐matched controls underwent analysis of serum lipid profile, oxidative stress biomarkers carotid duplex. Hydrogen peroxide (H 2 O ) malondialdehyde (MDA) were significantly higher than ( p ‐value < .001, <.001, respectively); on other hand,...
Enlarged facial pores are becoming a matter of cosmetic concern. Injections (botulinum toxin type A) have an increasing popularity among procedures.To determine the efficacy and safety intradermal injection botulinum in treatment excess sebum secretion enlarged pores.This split face-controlled pilot study was conducted on 20 patients with seborrhea. One cheek treated by toxin, other injected saline. Patient assessment performed after 1 then 4 months.At 1-month assessment, both sides showed...
<b><i>Background:</i></b> Angiogenesis is the production of new blood vessels from an existing vascular network; it plays a critical role in solid tumor development and metastasis. <b><i>Objectives:</i></b> To assess angiogenesis early cases mycosis fungoides (MF) to determine patterns MF dermoscopically. <b><i>Methods:</i></b> 25 patients with 20 healthy controls were included. The lesions assessed CD34...
Melasma is a hard-to-manage disorder with considerable relapsing behavior. Dermoscopy emerged to help in comprehensive evaluation of pigmentary disorders and melasma. The aim the study was evaluate potential role dermoscopy assessing melasma monitoring efficacy 1064-nm low-fluence Q-switched neodymium:yttrium-aluminum-garnet (QS Nd:YAG) laser. A total 31 patients facial were included. five laser sessions performed 2-week intervals. Patients evaluated at baseline 2 weeks after last session...
High interleukin (IL)-17 contributes to vitiligo pathogenesis. Vitamin D has been assessed in vitiligo, with no reports targeting its relation IL-17.To evaluate a possible regulatory effect of vitamin on IL-17 and their disease activity vitiligo.This study included 30 patients 40 controls evaluated for serum levels by ELISA technique.IL-17 was significantly higher (p = 0.001) whereas found be lower among the < 0.001). Multivariable regression performed relationship between demographic data...
Background Acne vulgaris is a multifactorial disease of the skin. Several studies have shown that sebocyte proliferation and/or lipogenesis, as well inflammatory reactions, may be regulated by peroxisome proliferator-activated receptor (PPAR)γ-mediated pathways. Aim To investigate whether Pro12Ala polymorphism PPARγ gene might associated with risk acne, and to assess effect this on acne severity. Methods This case–control study enrolled 100 patients apparently healthy subjects. The clinical...
Abstract Background Trichoscopy is a useful tool for diagnosis and follow‐up of alopecia areata (AA) patients. Both platelet‐rich plasma (PRP) intralesional corticosteroids (ILCs) are important treatment modalities patchy AA. Aim Trichoscopic AA monitoring the response to PRP versus ILCs in treatment. Patients/Methods This comparative study included 31 patients with AA, divided into two groups: (group A) received while B) once monthly 3 months. Evaluation was done by Severity Alopecia Tool...
None of therapeutic options for the treatment keloids has been found completely effective and satisfactory. A combination approach is best modality.To assess clinical safety efficacy radiofrequency (RF) followed by intralesional (IL) steroid injection in keloids.This pilot study included 18 patients who were suffering from keloids. All subjected to 3 4 sessions RF IL injection. Assessment scar volume both objective subjective parameters performed before after completion sessions.There was a...
Abstract Background Chronic hepatitis C virus (HCV) infection negatively impacts health-related quality of life (HRQL). We aimed to assess patient-reported outcomes (PROs) evaluate the impact treating chronic HCV with directly acting antivirals (DAAs) on HRQL. Methods PROs were assessed prospectively using PROQOL-HCV questionnaire before (week 0), at end 12), and after DAA treatment week 24. HRQL was measured in six different dimensions: physical health, emotional future uncertainty,...
Abstract Background Psoriasis is a common chronic, immune-mediated inflammatory skin disease. Despite the availability of several systemic therapeutic agents, treatment psoriasis remains challenge because associated adverse effects and/or financial burden these medications, given chronicity Objectives We aimed to compare efficacy and safety combined pulse azathioprine (AZA) low-dose methotrexate (MTX) vs. conventional dose MTX in patients with chronic plaque psoriasis. Methods In this...
To investigate the therapeutic efficacy and safety of growth factors combined with fractional carbon dioxide (CO2 ) laser in comparison CO2 alone a sample patients facial mature burn scars.Fifteen Egyptian bilateral scars were treated six sessions at 6-week intervals. Following each session, topical cocktail was applied to one side face split-face manner. Clinical evaluation by Vancouver Scar Scale (VSS), Patient Observer Assessment (PSOS), photography before 2 months after last session...
Background and Objectives To compare the efficacy safety of intradermal injection tranexamic acid (TXA) versus Q switched (QS) KTP (532 nm) in treatment facial ephelides. Study Design/Materials Methods A randomized comparative split‐face study included a total 30 female patients with bilateral One cheek was treated by intra‐dermal TXA injections other QS‐KTP nm). Patient assessment performed photography, pigmentation area, severity index spectrophotometry at baseline, 1 week after treatment,...
Plasmin (PL) is a potent inflammatory cell activator, and ultraviolet (UV)B has immunomodulatory effects on cutaneous responses. There are no previous studies comparing the effect of narrowband (NB)-UVB tissue PL levels in psoriasis.To estimate possible role pathogenesis psoriasis, to evaluate NB-UVB psoriasis.This case-control study enrolled 21 patients with psoriasis 20 clinically healthy volunteers matched for age sex. Patients underwent 24 sessions radiation. Biopsy samples using 4 mm...
Vitiligo is an acquired, multifactorial disorder of the skin and mucous membranes. An elevated homocysteine level has been described in vitiligo. Methylenetetrahydrofolate reductase (MTHFR) cystathionine B synthase (CBS) are major determinants metabolism.Determine serum levels vitiligo patients as well association between MTHFR (C677T, A1298C) CBSgene polymorphisms susceptibility to a sample those populations.Homocysteine were estimated by radioimmunoassay while detected polymerase chain...
Acral lesions of vitiligo are most likely recalcitrant to the known lines treatment. Ablative fractional CO2 has shown efficacy in treatment combination with other modalities.Thirty non-segmental patients acral lesion were included study. Each patient was subjected Carbon Dioxide Laser Treatment followed by application 5 fluorouracil (5FU) cream for five consecutive days. Evaluation done 3 weeks from start and 12 after last session using VESTA score, evaluation patients' photos blinded...
<b><i>Background:</i></b> Janus kinases (JAKs) are a family of non-receptor protein tyrosine that expressed in variety tissues. Several JAK-controlled cytokine receptor pathways incriminated the initiation and progression psoriasis. Genetic polymorphisms influencing JAK expression would be anticipated to have great impact on disease activity. <b><i>Objective:</i></b> The aim study was evaluate association between <i>JAK1</i>...
BackgroundDysregulation in transforming growth factor (TGF)‐β1 signalling pathways has been linked to cancer.
Alopecia areata (AA) is, an organ‐specific autoimmune disease, characterized by aberrant expression of cytokines the T helper 1 type. Tumour necrosis factor‐like weak inducer apoptosis (TWEAK) is a multifactorial cytokine that exerts role in pathogenesis inflammatory and diseases, especially cutaneous diseases. To estimate serum level TWEAK AA to correlate it with different parameters. This case–control study enrolled 40 patients 50 clinically healthy volunteers matched for age sex. A blood...
Trichoscopy is a simple, noninvasive procedure practiced in the diagnosis of multitude scalp and hair disorders. Hair shaft abnormalities usually represent diagnostic challenge to dermatologists.The aim study was determine practicality, versatility, value using handheld dermoscope assessment different hair/scalp disorders.Eight hundred seven patients both sexes, aged from 1 76 years, with complaints pertaining hair, were subjects study. All examined by dermoscope, 400 additionally...
Treatment of onychomycosis includes topical and systemic agents. However, prolonged use oral treatment could cause adverse effects antifungal agents have limited penetration. To compare the clinical efficacy safety fractional CO2 laser combined with tioconazole nail solution versus Q-switched 1064 Nd: YAG in fingernail onychomycosis. This randomized comparative trial was conducted on 13 patients (47 nails) Patients were to receive either or Q-Switched nm every 2 weeks for 3 months followed...
Abstract Background Spontaneous bacterial peritonitis (SBP) is a critical infection in patients with liver cirrhosis and ascites, necessitating early diagnosis for effective intervention. The standard diagnostic criterion SBP an ascitic fluid polymorphonuclear leukocyte (PMN) count of ≥ 250 cells/mm³. This study explored alternative markers SBP, including high sensitivity C-reactive protein (hsCRP), serum procalcitonin, urinary lipocalin, lactoferrin, homocysteine, fecal or calprotectin. Aim...