Chronic venous leg ulcers drastically reduce the quality of life affected patients. There is heightened interest in autologous platelet-rich plasma (PRP) as one promising therapies for ulcers.Our aim was to compare clinical efficacy PRP management chronic vs conventional treatment.In total, 40 patients with were included study. Twenty treated weekly 6 weeks (Group A), and 20 treatment (compression dressing) B). Treatment results calculated by percentage improvement area ulcer.Compared...

Abstract Background Several studies have addressed the association of metabolic syndrome (MetS) with androgenetic alopecia ( AGA ) in men few reports focusing on this females. The aim work was to investigate MetS among Egyptian women different stages female pattern hair loss FPHL and compare results age‐ sex‐matched controls. Methods This study included 90 participants, 45 cases classified according Ludwig scale healthy control participants that were cases. Assessment components done Adult...

Psoriatic plaques have been shown to contain increased levels of pro-inflammatory cytokines. Also, serum several cytokines reported elevated in psoriatic patients. It is postulated that changes cytokine production both locally and systemically could be useful monitoring disease activity. The aim this study was evaluate profile interleukin (IL)-8, γ-interferon (IFN-γ) tumor necrosis factor-α (TNF-α) Egyptian patients by enzyme-linked immunosorbent assay (ELISA) technique correlate these with...

Abstract Angiogenesis and microvascular endothelial injury play a role in the pathogenesis of systemic lupus erythematosus (SLE). Vascular growth factor (VEGF), key regulator angiogenesis, nail fold capillaroscopy (NFC) have been investigated few studies SLE with no reports targeting cutaneous manifestations. To evaluate NFC changes VEGF serum level relation to disease activity patients versus without Thirty (15 manifestations [group I], 15 II]) healthy controls were evaluated for levels,...

Background. There is raised interest in the involvement of interleukin-(IL-)23/T-helper 17 cells (Th17) axis pathogenesis psoriasis. Objectives. To compare effect narrow band ultraviolet B (NB-UVB) and methotrexate (MTX) therapy on serum levels IL-17 IL-23 psoriatic patients. Methods. Thirty patients with severe plaque psoriasis were included: 15 received NB-UVB three times weekly (group I) MTX 0.3 mg/kg per week II), both for 8 weeks. Before after treatment, investigated by ELISA technique...

High interleukin (IL)-17 contributes to vitiligo pathogenesis. Vitamin D has been assessed in vitiligo, with no reports targeting its relation IL-17.To evaluate a possible regulatory effect of vitamin on IL-17 and their disease activity vitiligo.This study included 30 patients 40 controls evaluated for serum levels by ELISA technique.IL-17 was significantly higher (p = 0.001) whereas found be lower among the < 0.001). Multivariable regression performed relationship between demographic data...

Background . Two preparations of botulinum A toxin (BTX-A) are commercially available for the treatment palmar hyperhidrosis (PPH): Botox (Allergan; 100 U/vial) and Dysport (Ipsen Limited; 500 U/vial), which not bioequivalent. Results regarding an appropriate conversion factor between them controversial. Objectives This paper aims to compare efficacy in PPH using a 1 : 2.5. Methods Eight patients with severe received intradermal injections one palm other same session. Clinical assessment was...

Summary Background Striae distensae ( SD ), a type of dermal scarring, are psychologically disappointing. To date, information and scientific research behind the role hormonal factors in development still unclear. It is vital to understand striae offer patients best therapeutic options. Objectives investigate early alterations regarding expression estrogen, androgen, glucocorticoid receptors (estrogen receptor ER androgen AR GR ) skin samples multigravida MG nulligravida NG cases compare...

Neo-angiogenesis is reported to be essential in the pathogenesis of oral lichen planus (LP). We aimed investigate angiogenesis through CD34 staining and vascular endothelial growth factor (VEGF) expression cutaneous LP lesions evaluate relation these markers with degree inflammation. Thirty patients 10 healthy controls were included. Skin biopsies from all subjects studied immunohistochemically for microvessel density (MVD) by VEGF expression. Relation parameters grade inflammation was...

To investigate the therapeutic efficacy and safety of growth factors combined with fractional carbon dioxide (CO2 ) laser in comparison CO2 alone a sample patients facial mature burn scars.Fifteen Egyptian bilateral scars were treated six sessions at 6-week intervals. Following each session, topical cocktail was applied to one side face split-face manner. Clinical evaluation by Vancouver Scar Scale (VSS), Patient Observer Assessment (PSOS), photography before 2 months after last session...

Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for treatment vitiligo. To histopathologically compare early effects NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E HMB-45. Methods: Thirty subjects with non-segmental vitiligo lesions were treated twice a week 6 weeks MEL, while was used treat contra laterally. Skin biopsies taken from lesional areas before...

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is an essential in the growth and maturation of blood cells as well modulation immune system. Few studies have investigated its involvement development vitiligo, no been performed on Egyptian patients.To assess GM-CSF serum level among non-segmental vitiligo patients to determine possible role etiopathogenesis disease.Forty with 40 age- sex-matched subjects were assessed for levels using ELISA technique.The this study showed...

Background Systemic Sclerosis (SSc) is characterized by skin thickening, fibrosis and vascular obliteration. The onset course are heterogeneous. Prominent features include autoimmunity, inflammation damage. Aim of Study To measure the level serum Anti-Annexin V antibodies in SSc patients to study its significance relation damage these patients. Patients Methods Twenty with (12 diffuse 8 limited form) 10 healthy age sex matched volunteers as controls were all subjected routine laboratory...

Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian contradictory results. Objective: aim here to assess the between GSTM1/T1 and susceptibility a larger sample patients generalized vitiligo. Methods: This study included 122 200 healthy controls that were age, gender matched. Assessment gene done using multiplex polymerase chain reaction (PCR). Results: Increased odds observed...

Introduction: Stretch marks, or striae distensae (SD), are the lesions of dermis caused by its linear atrophy at sites stretching. They occur in more than 70% pregnant women and adolescents as a result cutaneous This study aimed evaluating comparing clinical histological efficacy fractional CO2 laser versus long pulsed (LP) Nd: YAG treatment alba. Methods: Thirty female subjects having bilateral symmetrical stretch marks were managed LP on right side left side. The course consisted 3...

<title>Abstract</title> BACKGROUND Nail psoriasis is a chronic, inflammatory condition which difficult to treat, linked with greater severity, and may be associated anxiety significant functional impairment of the quality life. The 1064nm Nd:YAG laser was reported yield satisfactory results in treatment nail psoriasis. OBJECTIVE To assess clinical ultrasonographic efficacy long-pulsed fingernail compare its effect control fingernails. METHODS This intra-patient randomized controlled trial...

Abstract Nail psoriasis is a chronic, inflammatory condition which difficult to treat, linked with greater severity, and may be associated anxiety significant functional impairment of the quality life. The 1064 nm Nd: YAG laser was reported yield satisfactory results in treatment nail psoriasis. aim study assess clinical ultrasonographic efficacy long-pulsed fingernail compare its effect control fingernails. This intra-patient randomized controlled trial analyzed 86 fingernails collected...

Psoriasis is a common chronic systemic disease affecting the skin, nails, and joints. Nails are commonly associated with greater severity of disease. Radiofrequency (RF) nonionizing radiation that provides energy originating from electric current to generate heat inside dermis anti-inflammatory effects.

Genetic factors play an important role in the pathogenesis of vitiligo. Cyclooxygenase 2 (COX2) gene induced by ultraviolet radiation controls synthesis prostaglandins, which are found to be beneficial treating COX2 polymorphism has been previously evaluated Chinese population. We aimed study relation between two common polymorphisms with vitiligo and its subtypes amongEgyptian patients.This included 200 participants (100 patients 100 healthy controls). COX2-765G/C -1195A/G was studied...

Objective Vitiligo is a specific type of leukoderma characterized by depigmentation the epidermis. This study aimed to compare effectiveness methotrexate, narrow-band phototherapy, and corticosteroid as three different treatment modalities for vitiligo. Patients methods The included 52 patients suffering from nonsegmental vitiligo 20 healthy participants that served control group. They were recruited Dermatology Outpatient Clinic, National Research Center (Cairo, Egypt). randomly divided...