A5055820132- Cellular Mechanics and Interactions
- Advanced Fluorescence Microscopy Techniques
- Force Microscopy Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Hippo pathway signaling and YAP/TAZ
- Phagocytosis and Immune Regulation
- Microtubule and mitosis dynamics
- Neural dynamics and brain function
- Modular Robots and Swarm Intelligence
Université Paris Cité
2024-2025
ESPCI Paris
2023-2024
Sorbonne Université
2023-2024
Université Paris Sciences et Lettres
2023-2024
Centre National de la Recherche Scientifique
2023-2024
Institut Curie
2023-2024
Physique et Mécanique des Milieux Hétérogènes
2023-2024
Institut Pierre-Gilles de Gennes pour la Microfluidique
2023-2024
Focal adhesions are protein complexes that transmit actin cytoskeleton forces to the extracellular matrix and serve as signaling hubs regulate cell physiology. While their growth is achieved through a local force-dependent process, requirement of sustaining stress at scale suggests global regulation collective organization focal adhesions. To investigate evidence such large-scale regulation, we compared changes in shape adhesion-like structures during early spreading fibroblasts either on...
Animal cell shape changes are controlled by the actomyosin cortex, a peripheral actin network tethered to plasma membrane membrane-to-cortex attachment (MCA) proteins. Previous studies have focused on how myosin motors or turnover can generate local deformations required for morphogenesis. However, controls nucleation remains poorly understood. By combining molecular engineering with biophysical approaches and in situ characterization of cortical architecture, we show that tethering...
Abstract The cellular actin cortex provides crucial mechanical support and plays critical roles in numerous functions, including cell division migration. proteins of the ERM family, ezrin, radixin, moesin, are central to these processes by linking plasma membrane cytoskeleton. To investigate individual contributions three leukocyte migration, we generated single triple knock-out macrophages. Surprisingly, found that even absence ERMs, macrophages can still form different structures promoting...
Abstract The cellular cortex provides crucial mechanical support and plays critical roles during cell division migration. proteins of the ERM family, comprised ezrin, radixin, moesin, are central to these processes by linking plasma membrane actin cytoskeleton. To investigate contributions leukocyte migration, we generated single triple knockout macrophages. Surprisingly, found that even in absence proteins, macrophages still form different structures promoting such as filopodia,...