A5071687462- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Aquaculture disease management and microbiota
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Genomics and Phylogenetic Studies
- Hydrocarbon exploration and reservoir analysis
- Geological and Geophysical Studies
- Medicinal Plants and Neuroprotection
- Bioinformatics and Genomic Networks
- Natural Antidiabetic Agents Studies
- Essential Oils and Antimicrobial Activity
- Pharmaceutical and Antibiotic Environmental Impacts
- Marine and fisheries research
- Paleontology and Stratigraphy of Fossils
- Microbial Applications in Construction Materials
- Synthesis and Catalytic Reactions
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Fermentation and Sensory Analysis
- Steroid Chemistry and Biochemistry
- Analytical Chemistry and Chromatography
- Bioactive Compounds and Antitumor Agents
- Chemical synthesis and alkaloids
- Isotope Analysis in Ecology
Rhodes University
2017-2025
ABSTRACT Forest Fruits Organic Honey Vinegar (FFOHV) is a spontaneously fermented (yeast) and acetified (Acetic Acid Bacteria—AAB) Miombo Woodland honey vinegar developed in Zambia. Live vinegars containing live microbial cultures are marketed for their probiotic health benefits. The correlation between well‐developed gut microbiome human well studied products such as AAB contribute to healthy microbiome. This study details metagenomic analysis of stable, bottled FFOHV (Zambia) alongside two...
Feature-Based Molecular Networking (FBMN) is a popular analysis approach for LC-MS/MS-based non-targeted metabolomics data. While processing LC-MS/MS data through FBMN fairly streamlined, downstream handling and statistical interrogation often key bottleneck. Especially, users new to struggle effectively handle analyze complex matrices. In this protocol, we provide comprehensive guide the of results. We explain structure principles clean-up normalization, as well uni- multivariate...
Lithified layers of complex microbial mats known as microbialites are ubiquitous in the fossil record, and modern forms increasingly identified globally. A key challenge to developing an understanding microbialite formation environmental role is how investigate diverse communities situ . We selected living, layered (stromatolites) a peritidal environment near Schoenmakerskop, Eastern Cape, South Africa conduct spatial survey mapping composition small molecule production from samples....
The temperate marine sponge, Tsitsikamma favus, produces pyrroloiminoquinone alkaloids with potential as anticancer drug leads. We profiled the secondary metabolite reservoir of T. favus sponges using HR-ESI-LC-MS/MS-based molecular networking analysis followed by preparative purification efforts to map diversity new and known pyrroloiminoquinones related compounds in extracts seven specimens. Molecular taxonomic identification confirmed all five specimens (chemotype I) were found produce...
Sponges are important sources of bioactive secondary metabolites. These compounds frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to sponge progeny parent. In this study, we investigated communities associated with Tethya rubra Samaai and Gibbons 2005. Sponge specimens were collected Evans Peak RIY Banks reefs in Algoa Bay, South Africa taxonomically identified spicule analysis molecular barcoding. Crude chemical extracts...
Sponges of the Latrunculiidae family produce bioactive pyrroloiminoquinone alkaloids including makaluvamines, discorhabdins, and tsitsikammamines. The aim this study was to use LC-ESI-MS/MS-driven molecular networking characterize secondary metabolites produced by six latrunculid species. These are Tsitsikamma favus, pedunculata, Cyclacanthia bellae, Latrunculia apicalis as well recently discovered species, nguni michaeli. Organic extracts 43 sponges were analyzed, revealing distinct...
Lithified layers of complex microbial mats known as microbialites are ubiquitous in the fossil record, and modern forms increasingly identified globally. A key challenge to developing an understanding microbialite formation environmental role is how investigate diverse communities situ. We selected living, layered (stromatolites) a peritidal environment near Schoenmakerskop, Eastern Cape, South Africa conduct spatial survey mapping composition small molecule production from samples....
Ethnopharmacological relevanceCanarium schweinfurthii, also called ''Elemierd'Afrique'', is used in Cameroonian folk medicine (bark decoction) to treat patients suffering from hypertension.Aim of the study: This study aimed at evaluating antihypertensive activities stem bark Canarium schweinfurthii and identifying potential compounds present its extract that may support or oppose ethnomedicinial use.Materials methodsStem was prepared by maceration using 70 % ethanol followed redissolution...
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While anthropogenic pollution is a major threat to aquatic ecosystem health, our knowledge of the presence xenobiotics in coastal Dissolved Organic Matter (DOM) still relatively poor. This especially true for water bodies Global South with limited information gained mostly from targeted studies that rely on comparison authentic standards. In recent years, non-targeted tandem mass spectrometry has emerged as powerful tool collectively detect and identify pollutants biogenic DOM components...
Bacterial symbionts are critical members of many marine sponge holobionts. Some sponge-associated bacterial lineages, such as Poribacteria, SAUL, and Tethybacterales appear to have broad host ranges associate with a diversity species, while others more species-specific, having adapted the niche environment their host. Host-associated spirochete that numerically dominant been documented in several invertebrates including termites, starfish, corals. However, populations rare sponges, thus far...
Bacterial symbionts are critical members of many marine sponge holobionts. Some sponge-associated bacterial lineages, such as Poribacteria, unclassified lineage (SAUL), and Tethybacterales, appear to have broad-host ranges associate with a diversity species, while others more species-specific, having adapted the niche environment their host. Host-associated spirochete that numerically dominant been documented in several invertebrates including termites, starfish, corals. However, populations...
Evidence of life on earth dates back more than 3.4 billion years in the form lithified layers complex microbial mats known as microbialites, which are ubiquitous fossil record. Modern, extant microbialites comparatively rare but have been documented globally. Multi-faceted, molecular investigations required to understand community structure and function, factors that influence formation growth, how modern microbialite communities differ from those non-lithifying mats. In this study we...
Ethnopharmacological relevance: Canarium schweinfurthii, also called ‘’Elemierd’Afrique’’ in French, and its bark decoction is used Cameroonian folk medicine to treat patients suffering from hypertension.Aim of the study: This study aimed at identifying potential compounds present extract schweinfurthii that may be effective treatment hypertensionand support or oppose use traditional Pharmacopoeia.Materials methods: Stem was prepared by maceration using 70% ethanol. Ultra-Performance Liquid...
Adsorption of chemical pollutants by microplastics (MPs) has been investigated in prior studies, particularly Europe, Australia, and North America. However, most these studies have a laboratory marine environments few from the African continent context freshwater environments. In this study, we report results an in-situ study that adsorption three selected commonly used pharmaceutical drugs; sulfamethoxazole, ciprofloxacin, 17β-estradiol onto polyethylene terephthalate (PET) over two season:...