A5023157671- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Hydrocarbon exploration and reservoir analysis
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Geological and Geophysical Studies
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Fungal and yeast genetics research
- HIV/AIDS drug development and treatment
- Microbial Community Ecology and Physiology
- Paleontology and Stratigraphy of Fossils
- Mycorrhizal Fungi and Plant Interactions
- Crystallography and molecular interactions
- Molecular spectroscopy and chirality
- Gut microbiota and health
- Photosynthetic Processes and Mechanisms
- Geological Studies and Exploration
- HIV Research and Treatment
- Molecular Sensors and Ion Detection
- Synthesis and Characterization of Heterocyclic Compounds
- Carbohydrate Chemistry and Synthesis
- Organophosphorus compounds synthesis
- Biocrusts and Microbial Ecology
- Infectious Diseases and Mycology
Oregon State University
2019-2025
University of Montana
2014-2015
Missoula County Public Schools
2014
Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and biosynthesis primary secondary metabolites. In adaptation to marine environment, cyanobacteria use metallophores acquire trace metals when necessary as well reduce potential toxicity from excessive metal concentrations. Leptochelins A–C were identified structurally novel three geographically dispersed genus Leptothoe. Determination complex...
Filamentous fungi produce a vast number of asexual spores that act as efficient propagules. Due to their infectious and/or allergenic nature, fungal affect our daily life. Aspergillus species called conidia; formation involves morphological development and metabolic changes, the associated regulatory systems are coordinated by multiple transcription factors (TFs).
In the course of investigating living phosphatic stromatolites from Schoenmakerskop barrage pool near Gqeberha (Port Elizabeth), South Africa, we discovered new cyclic octadepsipeptides, amatyemides A (1) and B (2), named using Xhosa word ‘amatye’ for ‘rock’. The were isolated methanol extractions a targeted stromatolite sample collection, following an initial metabolomic survey pool. Planar structure elucidation 1 2 relied on NMR LCMS2 data, which delineated same six amino acids one...
An investigation of living phosphatic stromatolites from Schoenmakerskop barrage pool near Gqeberha (Port Elizabeth), South Africa, yielded new cyclic octadepsipeptides, amatyemides A (1) and B (2), named using the Xhosa word 'amatye' for 'rock'. The were isolated methanol extracts a targeted stromatolite sample collection, following an initial metabolomic survey pool. Planar structure elucidation 1 2 relied on NMR LCMS2 data, which delineated same six amino acids one...
(1)H NMR spectroscopic and X-ray crystallographic investigations of a 1,3-bis(4-ethynyl-3-iodopyridinium)benzene scaffold with perrhenate reveal strong halogen bonding in solution, bidentate association the solid state. A nearly isostructural host molecule demonstrates significant C-H hydrogen to same phases.
Bioactivity-guided isolation of Aspergillus ustus led to the discovery five new drimane sesquiterpenes, named ustusal A, ustusolate F and G, ustusoic acid A B, 1–5 respectively. Structural elucidation these fungal terpenes relied on 1D 2D NMR techniques, high-resolution mass spectrometry, chiroptical properties. Their relative configurations were determined by methods, while absolute established using comparative analyses computed experimental chemical shifts ECD spectra. The sesquiterpenes...
ABSTRACT Reptiles and amphibians (herptiles) are some of the most endangered threatened species on planet numerous conservation strategies being implemented with goal ensuring recovery. Little is known, however, about gut microbiome wild herptiles how it relates to health these populations. Here, we report results from characterization both a broad survey herptiles, correlation between fungus Basidiobolus , bacterial community supported by deeper, more intensive sampling Plethodon glutinosus...
Lithified layers of complex microbial mats known as microbialites are ubiquitous in the fossil record, and modern forms increasingly identified globally. A key challenge to developing an understanding microbialite formation environmental role is how investigate diverse communities situ . We selected living, layered (stromatolites) a peritidal environment near Schoenmakerskop, Eastern Cape, South Africa conduct spatial survey mapping composition small molecule production from samples....
Fungal natural products have inspired and enabled countless modern therapeutics. During a survey of the secondary metabolites endophytic fungi, we found that Aspergillus porosus produces new polyketides with interesting structural features named porosuphenols A–D (1, 2, 3a, 3b). The elucidation these was performed 1D 2D NMR techniques, Mosher ester analysis, J-based conformational isotope exchange studies. absolute configuration compounds determined using typical approaches including...
The synthesis of a bidentate halogen bonding receptor and nearly isostructural hydrogen analogue is described. Crystal structures reveal the interactions each with anions in solid state, while NMR titrations elucidate binding association constants solution. Of two, demonstrates stronger, water resistant halide competitive solvents.
Lithified layers of complex microbial mats known as microbialites are ubiquitous in the fossil record, and modern forms increasingly identified globally. A key challenge to developing an understanding microbialite formation environmental role is how investigate diverse communities situ. We selected living, layered (stromatolites) a peritidal environment near Schoenmakerskop, Eastern Cape, South Africa conduct spatial survey mapping composition small molecule production from samples....
Abstract From arid, high desert soil samples collected near Bend, Oregon, 19 unique bacteria were isolated. Each strain was identified by 16S rRNA gene sequencing, and their organic extracts tested for antibacterial antiproliferative activities. Noteworthy, six (30 %) exhibited strong inhibition resulting in less than 50 % cell proliferation more one cancer model, at 10 μg/mL. Principal component analysis (PCA) of LC/MS data revealed drastic differences the metabolic profiles found these...
Metals are important co-factors in the metabolic processes of cyanobacteria including photosynthesis, cellular respiration, DNA replication, and biosynthesis primary secondary metabolites. In adaptation to marine environment, use metallophores acquire trace metals when necessary as well reduce potential toxicity from excessive metal concentrations. Leptochelins A-C were identified structurally novel three geographically dispersed genus Leptothoe. The leptochelins halogenated linear NRPS-PKS...
ABSTRACT Reptiles and amphibians (herptiles) represent some of the more endangered threatened species on planet numerous conservation strategies are being implemented with goal ensuring recovery. Little is known, however, about wild gut microbiome herptiles how it relates to health populations. Here we report results from both a broad survey hosts intensive sampling geography fungi bacteria associated herptile microbiomes. We demonstrate that bacterial communities sampled frogs, lizards...
Evidence of life on earth dates back more than 3.4 billion years in the form lithified layers complex microbial mats known as microbialites, which are ubiquitous fossil record. Modern, extant microbialites comparatively rare but have been documented globally. Multi-faceted, molecular investigations required to understand community structure and function, factors that influence formation growth, how modern microbialite communities differ from those non-lithifying mats. In this study we...
Deep-sea methane seeps host highly diverse microbial communities whose biological diversity is distinct from other marine habitats. Coupled with community analysis, untargeted metabolomics of environmental samples using high resolution tandem mass spectrometry provides unprecedented access to the unique specialized metabolisms these chemosynthetic microorganisms. In addition, natural products are broad interest due their potential applications for human and health well-being. this...
Abstract Inspired by bioactive biaryl-containing natural products found in plants and the marine environment, a series of synthetic compounds belonging to azaBINOL chiral ligand family was evaluated for antiviral activity against HIV-1. Testing 39 unique azaBINOLs singleround infectivity assay resulted identification three promising compounds, including 7-isopropoxy-8-(naphth-1-yl)quinoline (azaBINOL B#24 ), which exhibited low-micromolar activity. The active several close structural...