A5068337058- Algal biology and biofuel production
- Social Policy and Reform Studies
- Regional Development and Policy
- Labor market dynamics and wage inequality
- Employment and Welfare Studies
- Income, Poverty, and Inequality
- Healthcare innovation and challenges
- Retirement, Disability, and Employment
- Diatoms and Algae Research
- University-Industry-Government Innovation Models
- Medicinal Plants and Bioactive Compounds
- European Union Policy and Governance
- Food Waste Reduction and Sustainability
- Microbial Natural Products and Biosynthesis
- Marine Biology and Environmental Chemistry
- Biochemical Acid Research Studies
- Metabolomics and Mass Spectrometry Studies
- Biocrusts and Microbial Ecology
- Firm Innovation and Growth
- Science, Research, and Medicine
- Intestinal Malrotation and Obstruction Disorders
- European Socioeconomic and Political Studies
- Entrepreneurship Studies and Influences
- Marine Ecology and Invasive Species
- Mitochondrial Function and Pathology
Universidade do Porto
2004-2025
Metals are important cofactors in the metabolic processes of cyanobacteria, including photosynthesis, cellular respiration, DNA replication, and biosynthesis primary secondary metabolites. In adaptation to marine environment, cyanobacteria use metallophores acquire trace metals when necessary as well reduce potential toxicity from excessive metal concentrations. Leptochelins A–C were identified structurally novel three geographically dispersed genus Leptothoe. Determination complex...
Essential trace metals are vital for cellular processes such as respiration, DNA replication, and photosynthesis. Cyanobacteria must tightly regulate metal homeostasis to prevent deficiency or toxicity, yet their metallophores remain overlooked. Here, we report lusichelins A-E (1-5), new isolated from the marine cyanobacterium Lusitaniella coriacea LEGE 07167. Their structures configurational assignments were determined using NMR, mass spectrometry, TD-DFT calculations, retrobiosynthetic...
Objetivo: Identificar as principais alterações gastrointestinais decorrentes da polifarmácia em idosos. Introdução: O aumento longevidade e a alta prevalência de doenças crônicas tornam o uso múltiplos medicamentos uma realidade comum nessa população, elevando risco eventos adversos como dispepsia, refluxo, gastrite, úlceras, má absorção na motilidade intestinal. Tais condições comprometem qualidade vida reforçam necessidade um manejo clínico cuidadoso. Referencial Teórico: envelhecimento...
The Blue Biotechnology and Ecotoxicology Culture Collection (LEGE-CC) holds a vast number of cyanobacteria whose chemical richness is still largely unknown. To expedite its bioactivity screening we developed natural products library. Sixty strains four environmental samples were chromatographed, using semiautomatic HPLC system, yielding 512 fractions that tested for their cytotoxic activity against 2D 3D models human colon carcinoma (HCT 116), non-cancerous cell line hCMEC/D3. Six showed...
ABSTRACT This article aims to assess the extent which social policies address current and persistent poverty in southern European Union countries general Portugal particular. The welfare regime, includes Greece, Italy, Spain, has been seen as less developed generous covering risks. Additionally, regime presents several inefficiencies that make much successful tackling poverty. In spite of having recently followed a common path reforms, are far from achieving substantial results reduction...
During the last decade development of Norte region Portugal has been object several studies whose conclusions - according to present paper need revision in line with a new scientific paradigm. It is our understanding that regional and innovation policies should be based on complex systems approach emergence acknowledged first part paper. Accepting usefulness this meta-theory for research firms’ behaviour innovation, we develop preliminary analysis strategic small medium-sized enterprises...
Metals are important co-factors in the metabolic processes of cyanobacteria including photosynthesis, cellular respiration, DNA replication, and biosynthesis primary secondary metabolites. In adaptation to marine environment, use metallophores acquire trace metals when necessary as well reduce potential toxicity from excessive metal concentrations. Leptochelins A-C were identified structurally novel three geographically dispersed genus Leptothoe. The leptochelins halogenated linear NRPS-PKS...
One of the top causes worldwide mortality is cancer. In many cases, effectiveness traditional chemotherapy hampered given emergence drug resistance alongside a wide range unwanted side effects. To overcome this, it essential to search for new drugs that can lead more successful cancer treatment. Cyanobacteria are diverse group photosynthetic prokaryotes known produce bioactive metabolites, with various interesting biotechnological applications. Currently, four FDA (food and...
Event Abstract Back to Bioactivity screening of cyanobacteria for the isolation novel anticancer compounds using 2D and 3D cell culture models Leonor Ferreira1, 2, 3*, Maria L. Sousa1, Marco Preto1, Vitor Vasconcelos1, 3 Ralph Urbatzka1* 1 Centro Interdisciplinar de Pesquisa Marine e Ambiental (CIIMAR), Portugal 2 Institute Biomedical Sciences Abel Salazar (ICBAS), Faculdade Ciências, Universidade do Porto, Cyanobacteria are microorganisms who produce secondary metabolites potentially...
The usage of paints and coatings with toxic components for the mitigation marine biofouling in submerged surfaces continues to cause economic, environmental human health-related problems worldwide. Natural products have potential provide solutions antifouling applications that are effective ecologically compatible. diversity secondary metabolites produced by cyanobacteria make these organisms a promising source bioactive compounds, especially when activity has already been documented....
Cancer has a tremendous negative socio-economic impact on our society. Thus, the discovery of new and more effective anticancer drugs is utmost importance. To address this societal challenge, main goal CYANCAN project was compounds from cyanobacteria. These photosynthetic bacteria are considered among most promising groups capable producing metabolites with pharmaceutical applications. A valuable underexplored natural resource that can underpin be found in Blue Biotechnology Ecotoxicology...