A5059712025- Computational Drug Discovery Methods
- Essential Oils and Antimicrobial Activity
- Piperaceae Chemical and Biological Studies
- Synthesis and biological activity
- Enzyme Structure and Function
- Amino Acid Enzymes and Metabolism
- Pancreatic function and diabetes
- Biochemical and Molecular Research
- Enzyme Catalysis and Immobilization
- Malaria Research and Control
- Air Quality Monitoring and Forecasting
- Bacterial Genetics and Biotechnology
- Phytochemicals and Antioxidant Activities
- Click Chemistry and Applications
- Biotin and Related Studies
- Antibiotic Use and Resistance
- Pharmaceutical and Antibiotic Environmental Impacts
- COVID-19 impact on air quality
- Phenothiazines and Benzothiazines Synthesis and Activities
- Diverse Scientific Research Studies
- Moringa oleifera research and applications
- Ethnobotanical and Medicinal Plants Studies
- Atmospheric aerosols and clouds
- HIV Research and Treatment
- RNA Interference and Gene Delivery
National Research and Innovation Agency
2023-2025
Bandung Institute of Technology
2020-2025
Indonesian Agency for Agricultural Research and Development
2024-2025
Padjadjaran University
2023-2024
National Nuclear Energy Agency of Indonesia
2023-2024
Osaka University
2021
Universitas Pertamina
2020
Pertamina (Indonesia)
2020
PM2.5 is a fine particle that has adverse health effects. Characterizing the diurnal variations and influence of meteorology critical for understanding drivers air pollution planning effective mitigation strategies. We studied variation its relationship with meteorological variables in seven cities representing Indonesia's three different rainfall patterns during 2021. used half-hourly concentrations obtained by quality monitoring system (AQMS), planetary boundary layer height (PBLH)...
Breynia cernua has been used as an alternative medicine for wounds, smallpox, cervical cancer, and breast cancer. This plant is a potential source of new plant-derived drugs to cure numerous diseases its multiple therapeutic functions. An in vitro study revealed that the methanol extract B. (stem) exhibits antioxidant activity according DPPH SOD methods, with IC50 values 33 8.13 ppm, respectively. The also exerts antibacterial against Staphylococcus aureus minimum bactericidal concentration...
Abstract Land restoration is expected to enhance the supply of valuable ecosystem resources such as herbaceous bushes and weeds. This study aimed determine primary phytochemical constituents bioactivities methanol extracts from eight weeds collected a restored post-mining landscape in South Kalimantan, Indonesia. Qualitative analysis showed presence phenolic compounds, flavonoids, tannins, alkaloids, steroids, terpenoids saponins plants. Their antioxidant activity was measured by using...
Mutant of lipase at oxyanion hole (H110 F) was constructed. The gene highly expressed in Eschericia coli BL21 (DE3) and the recombinant protein purified using Ni-NTA affinity chromatography. activity mutant enzyme significantly increased compared to that wild type. Further comparison showed both enzymes exhibited same optimum pH temperature, highest lipolytic on pNP-decanoate (C10). type appeared lost C14 C16 substrates meanwhile still up 20 %. In presence non polar organic solvent such as...
Background: Multidrug resistance in various cancer types is a major obstacle treatment. The concept of single drug molecular target often causes treatment failure due to the complexity cellular processes. Therefore, combination chemotherapy, which two or more anticancer drugs are co-administered, can overcome this problem because it potentially have synergistic efficacy besides reducing resistance, and doses. Previously, we reported that pyrazoline B had promising activity both silico vitro...
Context: Searching for novel anticancer-leading drugs is a current major concern providing better treatment outcomes. Piper nigrum one of the spice plants used as an anticancer in traditional medicine. Many studies reported secondary metabolite content P. nigrum. Some have been evaluated agents, but many still need to be studied. Aims: To evaluate silico activity metabolites. Methods: Cheminformatics and bioinformatics analysis were investigate drug-likeness, toxicity, pharmacokinetics, drug...
Context: Metastatic breast cancer is still categorized as an incurable disease because all available therapies are palliative treatments to relieve symptoms and increase life expectancy. Our previous study showed that N-pyrazoline-derived compounds have the potential antiproliferative drug in cervical cells line. Therefore, virtual screening conducted this predict anticancer of several molecules (chalcone pyrazoline derivatives) against before vitro testing. Aims: To screen chalcone...
Sanchez et al. (2005) have shown the structure of vector space genetic code over Galois field GF(4) which relate to physicochemical properties on proteins. From this space, an automorphism can be constructed reflect mutation process in code. This study investigates a type transformation LK_ITB5a lipase gene mutation. The result shows that there is matrix from wild mutant H110F diagonal with non-zero determinant. means automorphism. Key words: Automorphism, mutational pathways  
Plasmodium falciparum is the most common species of that causes malaria in Southeast Asia. Artemisinin, a drug with mechanism action by inducing oxidative stress infected red blood cells (RBC) currently used as main therapy for malaria, after resistance to chloroquine has been found. However, evidence artemisinin was discovered several regions Therefore, research required prove existence other drugs have anti-malaria effects. A candidate, doxorubicin also can induce formation inside cells....
β-hydroxy amino acids, such as serine, threonine, and phenylserine, are important compounds for medical purposes. To date, there has been only limited exploration of thermostable serine hydroxylmethyltransferase (SHMT) the synthesis these despite great potential that enzymes may offer commercial use due to their high stability catalytic efficiencies. ITBSHMT_1 (ITB clone number 1) from thermophilic methanol-tolerant bacteria Pseudoxanthomonas taiwanensis AL17 was successfully cloned....