A5091600898- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune Bullous Skin Diseases
- Nail Diseases and Treatments
- Asthma and respiratory diseases
- Syphilis Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Complementary and Alternative Medicine Studies
- Immunodeficiency and Autoimmune Disorders
- Plant Pathogens and Fungal Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Reproductive tract infections research
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Antimicrobial Resistance in Staphylococcus
- Immune Cell Function and Interaction
- Facial Rejuvenation and Surgery Techniques
- Laser Applications in Dentistry and Medicine
- Acne and Rosacea Treatments and Effects
- Skin Diseases and Diabetes
- Retinoids in leukemia and cellular processes
- Bacterial Identification and Susceptibility Testing
Riga Stradiņš University
2016-2025
Riga East University Hospital
2015-2024
Pauls Stradiņš Clinical University Hospital
2023
Art Academy of Latvia
2003
New therapies for complicated skin and structure infections (cSSSIs) are needed because of significant morbidity increasing antimicrobial resistance. Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause cSSSIs. Ceftaroline fosamil, novel parenteral cephalosporin with excellent in vitro activity against Gram-positive pathogens, including MRSA, many Gram-negative was evaluated as therapy cSSSIs multinational Phase III study. The primary study objective to determine...
The network of nature reserves that has been a centrepiece Ukraine's environmental policy devastated by Russian aggression. Violation their integrity threatens endemic species and irreplaceable ecosystems; indeed, entire ecosystems have lost; extensive fires, illegal logging, mechanical damage chemical contamination the soil cover are responsible for critical reduction in forest cover, degradation water conservation recreational functions reserve fund. Measures proposed to make best bad...
A new 8% ciclopirox-medicated nail lacquer (P-3051), based on a technology, revealed superior properties in terms of affinity to keratin, permeation, and ease use.This study aims assess the efficacy safety P-3051 vs. market ciclopirox lacquer.This is multicentre, randomized, three-arm, placebo-controlled, parallel groups, evaluator-blinded study. Overall, 467 patients with onychomycosis at least one big toenail were randomized receive P-3051, reference drug or placebo 2 : 1 ratio for 48-week...
Background and Objectives: Data on disease control, treatment, quality of life (QoL) in patients with psoriasis from Baltic countries are lacking. In this study, we aimed to assess the QoL Central Eastern Europe, report data for countries. Materials Methods: a cross-sectional, international study (CRYSTAL), retrospectively assessed real-world severity adult (18–75 years) Estonia, Latvia, Lithuania moderate-to-severe receiving continuous systemic treatment ≥ 24 weeks. Analyses included 50...
Psoriasis is a common, life-long skin disease with significant negative health and societal impact. Data on rates of control treatment strategies are lacking in Central Eastern European countries. We aimed to describe the real-world severity, control, for psoriasis patients from CRYSTAL (EUPAS36459) was cross-sectional, retrospective study adults (18–75 years) Bulgaria, Estonia, Hungary, Latvia, Lithuania, Romania, Russia. enrolled moderate-to-severe receiving continuous systemic ≥24 weeks....
This was a randomized, controlled, parallel-group clinical trial with blinded evaluator, designed to compare the efficacy and safety of nail lacquer P-3051 amorolfine 5% in treatment mild-to-moderate toenail onychomycosis. Patients were treated for 48 weeks daily, or twice weekly 5%. Out 120 evaluable patients, 60 (50.0%) received At baseline, two groups homogeneous terms race, pathogens, number affected toenails severity infected target area. The statistical superiority versus achieved...
Abstract Psoriasis is a chronic relapsing skin disease presenting with erythematous and papulous lesions infiltration extensive desquamation on the surface. It genetically determined, multifactorial dermatosis where genetic, immune, environmental factors play significant roles in its development. In Latvia treatment of different forms extensively spreading psoriasis, PUVA (psoralen ultraviolet A light therapy), combined method, administered, applying long-wave UVA radiation wavelength...
Abstract Methotrexate (MTX) is one of the first-line systemic treatment options in patients with moderate-to-severe plaque psoriasis and can be combined narrow band UVB phototherapy (Nb-UVB). However, such a combination rarely used for optimal duration due to safety efficacy concerns. The aim this study was assess methotrexate low doses Nb-UVB versus MTX monotherapy real-world setting. Retrospective patient medical chart review performed period from 2013 till 2019. therapy group (Group 1, n...
The research relevance of cancer diagnostics and treatment is determined by its widespread occurrence the lack adequate modern diagnostic methods. study aims to characterise new methods, namely screenings in detecting at early stages development. To achieve this goal, bibliosemantic bibliographic methods were used. Main results. Cancer leading cause morbidity mortality after cardiovascular diseases injuries many countries around world. Various are used combat problem, including computed...
This case report discusses immunoglobulin-induced erythema multiforme (EM), a rare and understudied condition that requires further investigation. The presents the of 69-year-old woman with history chronic lymphocytic leukemia who developed an acute hypersensitivity reaction to intravenous gamma globulin medication. patient received immunoglobulin (IVIG) normalize stabilize her levels reduce risk recurrent infections due immunodeficiency predominantly antibody defects. However, after second...
Abstract This article is aimed to provide an overview of psoriasis clinical aspects, available treatment options for moderate-to-severe in Baltics and summarises recommendations authors use different biologicals patients under a limited reimbursement environment.
Abstract Vitiligo is an acquired chronic skin disease, characterised by progressing, usually symmetric, depigmented areas in human skin. affects 0.5% of the population, however, optimal treatment combination real clinical practice has yet to be found. The aim study was assess whether combined therapy with ultraviolet B (UVB) and calcineurin inhibitors (CNI) provides superior response vitiligo patients, compared phototherapy or topical CNI monotherapy. We performed a retrospective cohort...
Abstract Psoriasis is one of the most common autoimmune dermatoses with a chronic relapsing course. Biologic therapy should be initiated for patients moderate to severe psoriasis when conventional systemic and phototherapy are ineffective, or their use limited due comorbidities. In Latvia, adalimumab first choice biologic drugs treatment psoriasis. The correlation between changes in cellular humoral immunological parameters clinical signs based on data from evaluated publication.
Change of TGF-β1 concentration in blood serum patients during systemic treatment severe psoriasis is a growth factor with multiple actions, responsible for many pathological and physiological processes. Radiation the skin narrowband 311 nm UVB light source most often used method therapy treatment. The aim study was to compare different methods on change two weeks statistically significantly lower than control group. For treatment, narrow band phototherapy applied 37 pharmacological...
Background There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim this study was to investigate safety and efficacy as an alternative treatment option for syphilis during pregnancy. Methods A retrospective analysis 79 treated conducted. Results No cases intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. average time seronegativation secondary symptoms 6.14 months ± 2.76, latent forms, it 7.52 1.84. Patients received no...
Optimised Routines for Monitoring of Treated Late Latent Syphilis Patients Highly sensitive and specific tests are needed in monitoring the serological activity efficacy treatment late latent syphilis. In a retrospective study, data 52 patients who had received syphilis were analysed Clinical Centre Skin Sexually Transmitted Diseases, Latvia. The diagnostic sensitivity specificity was calculated by Immunoblot IgG, Treponema Pallidum Immobilisation Reaction (TPIR) Express Diagnosis (SED)....