I. Botev

ORCID: 0000-0003-2371-8691
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About
Contact & Profiles
Research Areas
  • Cutaneous Melanoma Detection and Management
  • Immunotherapy and Immune Responses
  • Genetic and rare skin diseases.
  • Cancer Immunotherapy and Biomarkers
  • Melanoma and MAPK Pathways
  • Autoimmune Bullous Skin Diseases
  • Dermatological and Skeletal Disorders
  • RNA regulation and disease
  • Nonmelanoma Skin Cancer Studies
  • Cancer Diagnosis and Treatment
  • Cancer and Skin Lesions
  • vaccines and immunoinformatics approaches
  • Immune responses and vaccinations
  • Dermatologic Treatments and Research
  • Blood disorders and treatments
  • Oropharyngeal Anatomy and Pathologies
  • Neonatal Health and Biochemistry
  • Head and Neck Cancer Studies
  • Otitis Media and Relapsing Polychondritis
  • Complementary and Alternative Medicine Studies
  • Vascular Malformations and Hemangiomas
  • Ear and Head Tumors
  • Psoriasis: Treatment and Pathogenesis
  • Nail Diseases and Treatments
  • Beetle Biology and Toxicology Studies

National Specialized Hospital for Active Treatment of Hematologic Diseases
2024

Medical University of Sofia
1993-2020

Queen Giovanna Hospital
2011

University of Göttingen
1999

Basal cell carcinoma (BCC) is the most common paraneoplastic disease among human neoplasms. The tumor affects mainly photoexposed areas, often in head and seldom appears on genitalia perigenital region. BCC progresses slowly metastases are found less than 0.5% of cases; however, a considerable local destruction mutilation could be observed when treatment neglected or inadequate. Different variants as nodular, cystic, micronodular, superficial, pigment described literature differential...

10.4103/2229-5178.105456 article EN cc-by-nc-sa Indian Dermatology Online Journal 2013-01-01

Psoriasis is a common, life-long skin disease with significant negative health and societal impact. Data on rates of control treatment strategies are lacking in Central Eastern European countries. We aimed to describe the real-world severity, control, for psoriasis patients from CRYSTAL (EUPAS36459) was cross-sectional, retrospective study adults (18–75 years) Bulgaria, Estonia, Hungary, Latvia, Lithuania, Romania, Russia. enrolled moderate-to-severe receiving continuous systemic ≥24 weeks....

10.3389/fimmu.2024.1410540 article EN cc-by Frontiers in Immunology 2024-05-23

Immune function plays a prominent role in the defence against cutaneous malignant melanoma and increased risk of development during immunosuppression. Since immune system Is challenged beyond its routine activity by an infection, effect previous infectious diseases on may also be crucial. In European Organization for Research Treatment Cancer (EORTC) case-control study performed six countries Israel, we compared history severe infections 603 patients with that 627 population controls. We...

10.1097/00008390-199910000-00011 article EN Melanoma Research 1999-10-01

Oral condyloma acuminatum is a papillomatous lesion that transmitted most often sexually and associated with the human papilloma virus (HPV). This report describes case of 30-year-old woman multiple oral condylomata acuminata, located on lateral edges dorsum tongue. The incisional biopsy showed histological features compatible those acuminatum. E6 viral oncogene HPV types 6, 11, 16, 33 was identified by means polymerase chain reaction (PCR). lesions were removed radiodissecation treated...

10.1080/13102818.2006.10817314 article EN Biotechnology & Biotechnological Equipment 2006-01-01

Извършихме пилотно проучване с цел да апробираме хирургична техника по отношение на хиперплазията тубарната тонзила. При 11 пациенти (6 деца и 5 възрастни) след огледа дефинирането патологията в епифаринкса, ексцесивно хиперплазиралата лимфоидна тъкан областта торус тубариус се отстрани посредством апарат Coblаtor II (Arthrocare®). На контролните прегледи 6 месеца операцията 7 от оперираните показаха нормални аудиологични показатели, 3-ма имаха подобрение 1 получи рецидив. Ние считаме, че...

10.14748/orl.v7i1.7023 article BG International Bulletin of Otorhinolaryngology 2011-03-11

Целта на статията е да се направи кратък обзор физиологията и патологията тубарната тонзила. В детска възраст хиперплазията хроничните възпалителни заболявания фарингеалната лимфна тъкан могат доведат до назална обструкция, обструктивна сънна апнея участват в патогенезата риносинуити, рецидивиращия среден отит серозния отит. Досега за тази патология беше обвинявана предимно аденоидната вегетация. Редица автори считат, че тези нарушения дължат солитарна хиперплазия Разгледани са основните...

10.14748/orl.v7i2.7005 article BG International Bulletin of Otorhinolaryngology 2011-06-10

Abstract The group of congenital limb overgrowth syndromes associated with vascular malformations include various disorders, often variable clinical expression. Klippel-Trenaunay syndrome is the most common in this group, compared to other similar disorders such as Proteus, Parkes-Weber, Sturge-Weber, Cobb, Maffucii and CLOVES syndromes. We present a case 55-year-old male who presented swelling, pain, heaviness, numbness increased local temperature, involving right upper extremity side chest...

10.2478/amb-2020-0020 article EN cc-by-nc-nd Acta Medica Bulgarica 2020-07-01

10.1097/00008390-199309002-00028 article EN Melanoma Research 1993-09-01
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