A5076275881- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Sesquiterpenes and Asteraceae Studies
- Plant Toxicity and Pharmacological Properties
- Bioactive Natural Diterpenoids Research
- Catalytic C–H Functionalization Methods
Indian Institute of Technology Bombay
2020
University of Mumbai
2020
University of Arkansas for Medical Sciences
2020
Dehydroleucodine is a bioactive sesquiterpene lactone. Herein, four dehydroleucodine amino derivatives were synthesized using the amines proline, piperidine, morpholine, and tyramine, spectroscopic methods single-crystal X-ray diffraction unambiguously established their structures. The cytotoxic activity of these compounds was evaluated against eight acute myeloid leukemia cell lines, toxicity to peripheral blood mononuclear cells also determined. proline adduct most active compound, it...
The Mg-mediated conjugate addition of bromoform to a variety electron-deficient alkenes has been investigated. In the case nitrodienes and dibenzylideneacetones, tribromomethylated products were isolated, whereas spiro-cyclopropanated obtained with cyclic dibenzylideneketones 3-olefinic oxindoles. spiro-cyclopropyl ketones derived from successfully transformed into fused furans via Cloke-Wilson rearrangement.