A5072222831- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Reactions of Organic Compounds
- Inflammatory mediators and NSAID effects
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- Multicomponent Synthesis of Heterocycles
- HIV/AIDS drug development and treatment
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Eicosanoids and Hypertension Pharmacology
- Synthesis of Tetrazole Derivatives
- Food Science and Nutritional Studies
- HER2/EGFR in Cancer Research
- Enzyme function and inhibition
- Drug Solubulity and Delivery Systems
- Advances in Cucurbitaceae Research
- Coordination Chemistry and Organometallics
- Lung Cancer Research Studies
- Synthesis of Organic Compounds
- Natural Antidiabetic Agents Studies
- Chemical Reaction Mechanisms
- Synthesis and Reactivity of Heterocycles
Tokyo Metropolitan University
2025
Shri Jagdishprasad Jhabarmal Tibrewala University
2017
Savitribai Phule Pune University
2014
A new series of clubbed thiazolidinone-barbituric acid and thiazolidinone-triazole derivatives was synthesized to study the effect a hydrophobic unit, hydrogen bonding domain electron-donor group on compounds' anticonvulsant activity.The structures compounds were confirmed by their spectroscopic data elemental analysis.All evaluated for activity in two animal models seizures, viz.maximal electroshock seizure (MES) subcutaneous pentylenetetrazole (scPTZ).The also neurotoxicity.Compounds 4g,...
Background: The epidermal growth factor receptor (EGFR) regulates cell survival and proliferation, making it a key therapeutic target in cancer. EGFR tyrosine kinase inhibitors (TKIs) block signaling, preventing uncontrolled growth. However, current EGFR‐TKIs face resistance toxicity issues, necessitating optimized pharmacophores novel chemical entities (NCEs). Objectives: This study aimed to develop 3D quantitative structure‐activity relationship (QSAR) model for pharmacophore optimization...
Open‐chain tetrapyrroles and their analogues, consisting of four pyrrole rings linked by methylene or methine carbons, originate from natural synthetic pathways. These compounds exhibit unique structural flexibility due to extended p‐conjugation tunable coordination with metal ions, enabling precise control over electronic geometric properties. Such versatility makes them promising candidates for chiroptical, optoelectronic, bio‐related applications. By modulating molecular design,...
Most non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the deadlier gastrointestinal (GI) toxicities. The free -COOH group is responsible for GI toxicity associated with all traditional NSAIDs. In present research work, main objective was to develop new chemical entities as potential agents no results of synthesis and pharmacological screening a series hybrid molecules having general formula 2-(5-(5-(substituted...
A series of N(1) -(4-substituted-benzyl)-pyrimidines were subjected to 2D and 3D quantitative structure-activity relationship analyses. Statistically significant models generated, the most robust model for was obtained using simulated annealing-multiple linear regression. The physicochemical descriptors, viz., slogp, estate descriptors like SaaCHE index SdsCHE contribute significantly biological activity. pharmacophore requirements selective inhibition Mycobacterium tuberculosis thymidine...
For the treatment of NSCLC one promising strategies is targeted inhibition EGFR and its mutants. In this research work, we tend to epitomize design, synthesis, in-vitro anticancer evaluation novel indole-thiazole derivatives as reversible inhibitor which have trifling toxicity. The structure was designed considering standard drug EAI045. detailed study first generation, second third generation fourth inhibitors carried out before designing derivatives. results point toward 7(a-n) potential...
Abstract Introduction : Curcumin, an anticancer natural compound with multiple pharmacological activities, has a weak pharmacokinetic and instability due to diketone moiety. Curcumin's stability challenges can be overcome by removing the moiety shortening 7‐carbon chain, resulting in mono‐carbonyl analogs. Cancer proliferation is caused activation of Epidermal Growth Factor (EGFR) pathways. Current available EGFR inhibitors have issue resistance. Aim Thus, we aimed design new curcumin...
2D and 3D quantitative structure–activity relationship studies have been carried out for establishing a correlation between the structural properties of benzyl urea derivatives their anti-tumour activities. From this correlation, new chemical entities were designed, activity absorption, distribution, metabolism, excretion, toxicity also predicted. Finally, most promising compounds from these screening synthesized biologically evaluated anti-cancer properties. Compound 1-(2,...