A5101540950- Influenza Virus Research Studies
- Torture, Ethics, and Law
- International Law and Human Rights
- Trauma and Emergency Care Studies
- Acute Myeloid Leukemia Research
- Geriatric Care and Nursing Homes
- Emergency and Acute Care Studies
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Health disparities and outcomes
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Immune Response and Inflammation
- Telemedicine and Telehealth Implementation
- COVID-19 Clinical Research Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Military and Defense Studies
- COVID-19 and Mental Health
- Economic Sanctions and International Relations
- Child Welfare and Adoption
- Shoulder Injury and Treatment
- Healthcare Systems and Technology
- Bone and Joint Diseases
- Medical Device Sterilization and Disinfection
University of Colorado Denver
2024
Institute of Environmental Science and Research
2011-2023
University of Calgary
2023
University of Northern British Columbia
2020-2022
Harvard University
2021
The University of Queensland
2021
Broad Institute
2021
Canmore Museum and Geoscience Centre
2021
Massachusetts Institute of Technology
2021
University of Ottawa
2020
Clonal hematopoiesis results from somatic mutations in cancer driver genes hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an unbiased analysis sequencing data 84,683 persons and identified common the 5-methylcytosine reader,
Cytokines and chemokines are key signaling molecules of the immune system. Recent technological advances enable measurement multiplexed cytokine profiles in biological samples. These can then be used to identify potential biomarkers a variety clinical phenotypes. However, testing for such associations each separately ignores highly context-dependent covariation secretion decreases statistical power detect due multiple hypothesis testing. Here we present CytoMod-a novel data-driven approach...
This paper uses data from multiple surveillance systems to describe the experience in New Zealand with second complete wave of pandemic influenza A(H1N1)2009 2010. Measures such as hospitalisation rates suggest overall impact 2010 was between half and two thirds that first 2009. There considerable regional sub-regional variation a tendency for higher activity areas experienced low Demographic characteristics were similar those 2009 highest seen children under age five years, indigenous Māori...
Cardiac rehabilitation programs (CRP) are effective evidence-based secondary prevention that reduce morbidity and mortality in patients with cardiovascular disease (CVD). However, participation remains suboptimal, resulting under-treatment greater risk for recurrent cardiac events. Understanding the reasons behind CRP dropout is urgently needed to inform development of best meet patient needs support sustained engagement.The aim this study was identify understand factors impacting from...
Abstract: A novel nuclear factor κB (NF‐κB) binding sitehas been identified within the promoter region of mouse gene encodingcholine acetyltransferase (ChAT), enzyme that synthesizes acetylcholineand has implicated in cognitive deficits associated with aging andAlzheimer's disease. This site, which is located nervegrowth (NGF)‐responsive enhancer element, was recognized by theNF‐κB protein p49 but not p65 or p50. from both basal forebrain andPC12 extracts interacted this specific sequence...
The failure to mount an antibody response following viral infection or seroconversion is a largely underappreciated and poorly understood phenomenon. Here, we identified immunologic markers associated with robust responses after influenza virus in two independent human cohorts, SHIVERS FLU09, based Auckland, New Zealand Memphis, Tennessee, USA, respectively. In the cohort, significantly associates (1) hospitalization, (2) greater numbers of proliferating, activated CD4+ T cells, but not CD8+...
Abstract How a history of influenza virus infections contributes to protection is not fully understood, but such might explain the contrasting age distributions cases two lineages B, B/Victoria and B/Yamagata. Fitting statistical model those using surveillance data from New Zealand, we found they could be explained by historical changes in lineage frequencies combined with cross-protection between strains same lineage. We additional against B/Yamagata people for whom it was their first B...
Trimethylaminuria (TMAU) is an inborn error of metabolism characterized by the excess trimethylamine (TMA) in various bodily secretions. Increased TMA secretions affected individuals causes a body odor similar to decaying fish despite appropriate hygiene practices. Although accumulation not toxic body, symptoms associated with TMAU have profound effects on individual's mental health. Many complaints odor, or without confirmed diagnosis, report feeling dismissed healthcare professionals...
Opioids are often necessary for patients experiencing high-intensity pain. However, side effects exist and some may misuse opioids. To better understand how opioids prescribed to with early-stage cancer enhance opioid safety, clinicians' views of prescribing were explored.This was a qualitative inquiry including any Alberta clinician cancer. Semistructured interviews conducted nurse practitioners (NP), medical oncologists (MO), radiation (RO), surgeons (S), primary care physicians (PCP),...
Currently, the use of quality indicators in surgical setting may be challenged by diverse patient needs, clinical complexity, and health trajectories. Therefore, objective this study was to examine adaptability existing a context propose new time points.A multi-method approach included an environmental scan literature, consultation with multinational experts, analysis data. Quality from nurse-administered interRAI Acute Care instrument were examined within using secondary data hospital...
<div>Abstract<p>Clonal hematopoiesis results from somatic mutations in cancer driver genes hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an unbiased analysis sequencing data 84,683 persons and identified common the 5-methylcytosine reader <i>ZBTB33</i> as well <i>YLPM1, SRCAP</i>, <i>ZNF318</i>. also these at low frequency patients with myelodysplastic syndrome. <i>Zbtb33</i>-edited mouse...
<div>Abstract<p>Clonal hematopoiesis results from somatic mutations in cancer driver genes hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an unbiased analysis sequencing data 84,683 persons and identified common the 5-methylcytosine reader <i>ZBTB33</i> as well <i>YLPM1, SRCAP</i>, <i>ZNF318</i>. also these at low frequency patients with myelodysplastic syndrome. <i>Zbtb33</i>-edited mouse...