A5017276766- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Semiconductor materials and interfaces
- Semiconductor Quantum Structures and Devices
- Thin-Film Transistor Technologies
- CRISPR and Genetic Engineering
- GaN-based semiconductor devices and materials
- Silicon Nanostructures and Photoluminescence
- Silicon and Solar Cell Technologies
- Pluripotent Stem Cells Research
- Advanced Biosensing Techniques and Applications
- Nanowire Synthesis and Applications
- Spectroscopy and Quantum Chemical Studies
- Optical Coatings and Gratings
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Intermetallics and Advanced Alloy Properties
- Magnetic properties of thin films
- ZnO doping and properties
- Surface and Thin Film Phenomena
- Magnetic Field Sensors Techniques
- Glioma Diagnosis and Treatment
- FOXO transcription factor regulation
- Semiconductor materials and devices
- Cancer Research and Treatments
Hyundai Motor Group (South Korea)
2022
Cedars-Sinai Medical Center
2013-2020
Rockefeller University
2020
University of California, Santa Cruz
2020
Broad Institute
2020
Green Cross (South Korea)
2016
Samsung (South Korea)
2005-2015
Korea Advanced Institute of Science and Technology
2014
California Institute for Regenerative Medicine
2012
University at Buffalo, State University of New York
2005-2007
The structure of water was investigated at the quartz/water interface in presence supported lipid bilayers (SLBs) by use infrared−visible sum frequency spectroscopy. By varying pH bulk solution and charge on SLB, changes both ice-like water-like peaks were observed OH stretch region with respect to plain interface. oscillator strengths most affected applying charged SLBs, rather than that did not contain a net charge. Time-dependent studies peak intensity 5.6 during fusion vesicles bare...
We investigate the effects of refractive index encapsulant on light-extraction efficiency (LEE) light-emitting diodes (LEDs) for GaN LEDs (n ≈ 2.5) and AlGaInP 3.0). For non-absorbing rectangular parallelepiped LED chips, as increases, LEE first increases quasi-linearly, then sub-linearly, finally a saturation is reached. Furthermore, with dual-layer graded-refractive-index (GRIN) (n(encapsulant 1) = 1.57 n(encapsulant 2) 1.41) fabricated through two-step curing process. demonstrate that...
Highlights•MADR enables single-locus somatic genetic modification and lineage tracing in vivo•MADR can be used to interrogate the dosage response of transgenes allows "personalized" brain tumor modeling vivo via CRISPR variants or transgenes•MADR is adaptable hundreds available mouse linesSummaryIn situ transgenesis methods such as viruses electroporation rapidly create transgenic mice but lack control over copy number, zygosity, locus specificity. Here we establish mosaic analysis by dual...
As the list of putative driver mutations in glioma grows, we are just beginning to elucidate effects dysregulated developmental signaling pathways on transformation neural cells. We have employed a postnatal, mosaic, autochthonous model that captures first hours and days gliomagenesis more resolution than conventional genetically engineered mouse models cancer. provide evidence disruption Nf1-Ras pathway ventricular zone at multiple nodes uniformly results rapid stem cell depletion,...
We used vibrational sum frequency spectroscopy (VSFS) to investigate lysozyme adsorption at the quartz/water and air/water interfaces. These investigations found that water structure depended intimately on bulk pH both hydrophobic, air, hydrophilic, quartz, Changes in interfacial potential caused by protonation/deprotonation of titratable groups protein (as well as quartz case solid/liquid studies) played a major role this. Furthermore, intensity CH stretch range from was observed under all...
Significance Medulloblastoma (MB) is a tumor of the cerebellum that primarily forms in pediatric patients during brain development. The immune system ultimately fails to eradicate MB because it “blind” cells as result poor surveillance caused by existence blood–brain barrier and brain’s privileged status. Another mechanism escape suppressors act “smokescreen,” blocking effective antitumor immunity. We show blockade TGF-β signaling pathway promotes memory T cell development, conferring...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation Ming Ma, David S. Meyaard, Qifeng Shan, Jaehee Cho, E. Fred Schubert, Gi Bum Kim, Min-Ho Cheolsoo Sone; Polarized light emission from GaInN light-emitting diodes embedded with subwavelength aluminum wire-grid polarizers. Appl. Phys. Lett. 6 August 2012; 101 (6): 061103. https://doi.org/10.1063/1.4744422...
Sum frequency spectra of gramicidin A at the air/water interface in partially deuterated dimyristoylphosphatildycholine monolayers were collected as a function surface pressure and mole fraction peptide. Reorganization lipid peptide molecules followed between 5 35 mN/m. Selective deuteration enabled independent observation ordering tail headgroup regions. The results from pure monolayer studies revealed that both portions amphiphile rearranged roughly tandem pressure. When membrane was added...
IR-visible sum frequency spectroscopy (SFS) was employed to investigate the molecular level details of adsorption positively charged polyelectrolyte, polydiallyldimethylammonium chloride (PDDA), at quartz/water interface. Below pH 9.0, signal from interfacial water structure visible, but none adsorbed polymer could be detected. This indicated that PDDA not well enough aligned interface under these conditions elicit a response. At more basic values (>or=9.6), however, molecules became...
Trophic factor delivery to the brain using stem cell-derived neural progenitors is a powerful way bypass blood-brain barrier. Protection of diseased neurons this technology promising therapy for neurodegenerative diseases. Glial cell line-derived neurotrophic (GDNF) has provided benefits Parkinsonian patients and being used in clinical trial amyotrophic lateral sclerosis. However, chronic trophic prohibits dose adjustment or cessation if side effects develop. To address this, we engineered...
Difference in the vibes! The effect of divalent metal-cation absorption on structure water at aqueous interfaces was explored presence deprotonated fatty acid monolayers. Vibrational spectra were obtained from charged monolayers Zn2+ and Mg2+ ions using vibrational sum frequency spectroscopy (see graphic). differing modes coordination by two cations to carboxylate headgroups led significantly different structures interfaces.
Recent findings have indicated the presence of a progenitor domain at marginal zone/layer 1 cerebral cortex, and it has been suggested that these progenitors neurogenic gliogenic potential. However, their contribution to histogenesis cortex remains poorly understood due difficulties associated with genetically manipulating unique cells in population-specific manner. We adapted electroporation technique target pial surface for rapid genetic manipulation postnatal day 2. In vivo data show most...
Self-assembled nanobridges, 30–80 nm in diameter and 1–2μm length, have been fabricated using spontaneously grown nanowires by the metal-induced growth method at 575 °C. Ni as a catalyst was first deposited on SiO2-coated Si wafers. sputtered from target dc magnetron system. A solid-state reaction of with provided highly linear nanowires. These single-crystal NiSi composition. Laterally propagated formed nanobridges passing through vertically trenched region, without trench sidewall. The...
The authors report on the development and demonstration of high power operation optically end-pumped vertical external cavity surface emitting laser devices at 532 460nm. 2.7W green 1.4W blue output powers were achieved with a good beam quality by intracavity frequency doubling second harmonic generation crystal. High efficiency are attributed to enhanced thermal management diamond heat spreader directly bonded gain region effective optical pumping placing pump diode behind structure.
An effective method to enhance the light extraction for GaInN light-emitting diodes (LEDs) is reported. The employs TiO2 micro-pillars with tapered sidewalls, which are refractive-index-matched underlying GaN. fabricated by using reflowed photoresist as mask during CHF3-based dry etch, O2 added in order precisely control taper angle. LEDs patterned sidewalls show a 100% enhancement light-output power over planar reference LEDs. measured results good agreement ray-tracing simulations, showing...
A ternary compound of Co3Ti2Si is suggested as a reaction barrier for the formation epitaxial CoSi2 in Co/Ti/Si system when adopting rapid thermal annealing process. It controls Co diffusion to Si substrate, followed by CoSi2. After was formed, interfacial morphology upper layer/ interface very different according silicidation temperature, that is, planar at 800 °C, but rough 900 °C. This attributed between layer consisting Co–Ti–Si and which resulted Ti-rich precipitates surface. The acted...
We report a high-power fundamental transverse mode operation of an optically pumped 920-nm vertical-external- cavity surface-emitting laser. The effects the gain related structural parameters on laser performance are investigated. Based optimization structure and thermal management, maximum pump-limited output power 12 W in TEM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">00</sub> with slope efficiency 58% (input 24 W) was achieved at room...
We report on the demonstration of highly efficient blue lasers based intracavity frequency doubling vertical-external-cavity surface-emitting (VECSELs). By optimizing number InGaAs quantum wells and employing Al0.3Ga0.7As carrier blocking layers in resonant periodic gain structures, we observed pump-power-limited output power 4.5W at 920nm for an InGaAs∕GaAs well VECSEL. With a LiB3O5 crystal inside cavity, 1.9W continuous-wave 460nm was demonstrated. Power conversion efficiencies (=output...
A ternary compound of Co3Ti2Si is suggested as reaction barrier for the formation epitaxial CoSi2 in Co/Ti/Si system. It has a role to control Co diffusion Si substrate, followed by CoSi2. After was formed, CoO and Ti oxide were formed at surface, depending on thickness. In case being outdiffusion accelerated. Then, decomposition occurred with oxide, resulting uniform However, suppressed, thermally Co3Ti2Si. This caused nonuniform supply form