A5002351889- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Electrolyte and hormonal disorders
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Diabetes Management and Research
- Dialysis and Renal Disease Management
- Cardiovascular Function and Risk Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pneumocystis jirovecii pneumonia detection and treatment
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Nitric Oxide and Endothelin Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Aortic Thrombus and Embolism
- Infective Endocarditis Diagnosis and Management
- Vasculitis and related conditions
- Antiplatelet Therapy and Cardiovascular Diseases
- Renal function and acid-base balance
- HIV/AIDS drug development and treatment
- Sepsis Diagnosis and Treatment
- Potassium and Related Disorders
- Sodium Intake and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Martin Luther University Halle-Wittenberg
2012-2025
Carl-Thiem-Klinikum Cottbus
2019-2022
Goethe University Frankfurt
2009-2022
University Hospital Leipzig
2021
University Hospital in Halle
2011-2020
University of Nebraska Medical Center
2001-2015
King's College London
2012
British Heart Foundation
2012
Düsseldorf University Hospital
2012
Justus-Liebig-Universität Gießen
2012
The function of Nox4, a source vascular H(2)O(2), is unknown. Other Nox proteins were identified as mediators endothelial dysfunction.We determined the Nox4 in situations increased stress induced by ischemia or angiotensin II with global and tamoxifen-inducible Nox4(-/-) mice.Nox4 was highly expressed endothelium contributed to H(2)O(2) formation. mice exhibited attenuated angiogenesis (femoral artery ligation) PEG-catalase treatment control had similar effect. Tube formation cultured lung...
Background— HMG-CoA reductase inhibitors (statins) have been shown to beneficially affect outcomes in chronic heart failure (CHF). We hypothesized that statins exert effects on autonomic function, as assessed by plasma norepinephrine levels, direct recordings of renal sympathetic nerve activity (RSNA), and baroreflex function. Methods Results— Normolipidemic CHF rabbits were treated with simvastatin or vehicle. was induced continuous ventricular pacing at 320 340 bpm for 3 weeks. Two days...
Background.Pneumocystis jiroveci pneumonia (PcP) is a potentially life-threatening complication in renal transplant recipients with increased reports during the past few years. Individual risk factors for susceptibility to PcP are incompletely understood. Methods. We retrospectively analysed 60 cases of confirmed PcP, diagnosed six German centres between 2004 and 2008, as well matched controls. Results. Compared controls, revealed following significant differences: had poorer function (eGFR...
Inhibitors of hydroxymethylglutaryl-CoA reductase or statins have been shown to alleviate endothelial dysfunction. Their effects on constitutive nitric oxide synthase in the central nervous system may hypothetically affect autonomic balance sympathoexcitatory states, such as chronic heart failure (CHF). To address this issue, simvastatin (SIM) (0.3, 1.5, 3 mg · kg -1 day po) was given rabbits with pacing-induced CHF over a 3-wk period. Normal and vehicle-treated served controls. Autonomic...
Sympatho-excitation is a hallmark of the chronic heart failure (CHF) state. It has long been assumed that this sympatho-excitation mediated by reduction in sensory input from cardiopulmonary and arterial baroreceptors. However, recent data suggest these reflexes may only be important initiation sympatho-excitatory state not necessary for sustained increase sympathetic nerve activity (SNA) CHF. Two humoral factors can influence SNA are nitric oxide (NO) angiotensin II (AngII). Animals with...
Epoxyeicotrienoic acids (EETs) are cytochrome P450-dependent anti-hypertensive and anti-inflammatory derivatives of arachidonic acid, which highly abundant in the kidney considered reno-protective. EETs degraded by enzyme soluble epoxide hydrolase (sEH) sEH inhibitors treatment for chronic renal failure (CRF). We determined whether inhibition attenuates progression CRF 5/6-nephrectomy model (5/6-Nx) mice. 5/6-Nx mice were treated with a placebo, an ACE-inhibitor (Ramipril, 40 mg/kg),...
One of the key mechanisms involved in renal Na + retention chronic heart failure (CHF) is activation epithelial channels (ENaC) collecting tubules. Proteolytic cleavage has an important role activating ENaC. We hypothesized that enhanced levels proteases tubular fluid activate ENaC, resulting rats with CHF. CHF was produced by left coronary artery ligation rats. By immunoblotting, we found several urinary serine were significantly increased compared sham (fold increases: furin 6.7, prostasin...
Endothelin-1 (ET-1) is elevated in chronic heart failure (CHF). In this study, we determined the effects of ET-1 blockade on renal sympathetic nerve activity (RSNA) conscious rabbits with pacing-induced CHF. Rabbits were chronically paced at 320–340 beats/min for 3–4 wk until clinical and hemodynamic signs CHF present. Resting RSNA arterial baroreflex control determined. Responses before after antagonist L-754,142 (a combined ET A B receptor antagonist, n = 5) was administered by osmotic...
The reflex regulation of sympathetic nerve activity has been demonstrated to be impaired in the chronic heart failure (CHF) state compared with normal condition (Liu JL, Murakami H, and Zucker IH. Circ Res 82: 496–502, 1998). Exercise training (Ex) appears beneficial patients CHF shown reduce outflow this disease (Hambrecht R, Hilbrich L, Erbs S, Gielen Fiehn E, Schoene N, Schuler G. J Am Coll Cardiol 35: 706–713, 2000). We tested hypothesis that Ex corrects reduced cardiopulmonary (CP)...
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic reactions and cosubstrate signaling pathways of cells. While the intracellular function NAD well described, much less known about its importance as an extracellular molecule. Moreover, there only little information concentration ratio between oxidized (NAD+) reduced (NADH) form humans. Therefore, our study aimed at analysis total NAD+/NADH human plasma depending on sex age. First, enzymatic assay was established for detecting...
Abstract Background Pneumocystis jirovecii pneumonia (PcP) remains a life‐threatening opportunistic infection after solid organ transplantation, even in the era of prophylaxis. The association between risk developing PcP and low CD4 + T cell counts has been well established. However, it is unknown whether lymphopenia context post‐renal transplant increases mortality. Methods We carried out retrospective analysis cohort kidney patients with (n = 49) to determine factors for mortality...
Abstract Aims Acute cardiorenal syndrome (CRS) with and without consideration of the volume state was assessed regard to inflammatory parameters. Methods results Blood samples from patients acute CRS (Ronco type 1 or 3, Group 1, n = 15), end‐stage renal disease (Group 2, 12), hypertension and, in a second cohort, hypervolemia 4, 9) 5, 10) were analysed lipopolysaccharide‐binding protein (LBP), interleukins (ILs), monocyte function (flow cytometry) both on admission (all groups) discharge...
Here, we report a case of central pontine demyelinization in type-2 diabetes patient with hyperglycemia after binge-eating attack the absence relevant hyponatremia. A 55-year-old, male diabetic liver cirrhosis stage Child-Pugh B was admitted due to dysmetria his right arm, gait disturbance, dizziness, vertigo, and polyuria, polydipsia sweets (a whole fruit cake 2 Liters soft drinks). recently initiated insulin therapy had been discontinued for 8 months. serum glucose measurement obtained 5...
Dysregulation of the autonomic nervous system is frequent in subjects with cardiovascular disease. The contribution different forms renovascular hypertension and mechanisms contributing to dysfunction are incompletely understood. Here, murine models preserved (2-kidneys-1 clip, 2K1C) reduced (1-kidney-1 1K1C) kidney mass were studied regard regulation (sympathetic tone: power-spectral analysis systolic blood pressure; parasympathetic heart rate) baroreflex sensitivity rate by spontaneous,...
Calciphylaxis cutis is characterized by media calcification of arteries and, most prominently, cutaneous and subcutaneous arterioles occurring in renal insufficiency patients.A 53-year-old woman with chronic cardiac failure complained painful crural, non-varicosis ulcers. She was hospitalized an immobilized condition due to both the crural ulcerations existing heart-failure state (NYHA III-IV) having pleural pericardial effusions, atrial fibrillation weight loss 30 kg over past year. Despite...
Cardiovascular comorbidities regularly determine renal function. We report a case of acute kidney injury (Acute Kidney Injury Network stage 3) due to an intermittent third-degree atrioventricular block, which had not been diagnosed before. A 76-year-old Caucasian man with liver cirrhosis non-alcoholic fatty disease, and type-2 diabetes was cognitively impaired reduced vigilance presumably caused by hepatic encephalopathy and/or Alzheimer dementia. Within 2 years, two hospitalizations...