A5002642323- Growth Hormone and Insulin-like Growth Factors
- Effects and risks of endocrine disrupting chemicals
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Toxic Organic Pollutants Impact
- Sperm and Testicular Function
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Sexual Differentiation and Disorders
- Protein Tyrosine Phosphatases
- Estrogen and related hormone effects
- Fibroblast Growth Factor Research
- Testicular diseases and treatments
- Galectins and Cancer Biology
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Cancer Cells and Metastasis
- Ophthalmology and Eye Disorders
- Congenital heart defects research
- Cancer, Hypoxia, and Metabolism
- Insect and Pesticide Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hedgehog Signaling Pathway Studies
- Adrenal Hormones and Disorders
- Nanoplatforms for cancer theranostics
Lund University
2009-2014
University of Turku
2005-2008
University of Amsterdam
2000-2005
Amsterdam UMC Location University of Amsterdam
2000-2004
Japan External Trade Organization
1998-2003
Endometrial prostaglandins (PGs) and the PGE2/PGF2alpha ratio play an important role in regulating estrous cycle establishment of pregnancy. The enzymes downstream cyclooxygenase-2 may determine porcine uterus. Thus, we have cloned PGF synthase (PGFS) microsomal PGE synthase-1 (mPGES-1) characterized their expression endometrium during early PGFS mPGES-1 amino acid sequences possessed a high degree (>67% >77%, respectively) identity with other mammalian homologs. There was little modulation...
TSH secretion from the anterior pituitary is mainly regulated by TRH and thyroid hormones. We hypothesized that in addition itself could modulate production sensing its own release, enabling fine-tuning of secretion. For such an ultra-short loop control, should contain a receptor (TSH-R). To find evidence for this we screened human complementary DNA library with digoxigenin-labeled TSH-R probe found 2 positive clones 32,000 plaques. One clone was sequenced to be completely identical TSH-R....
TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) has a potency to induce decreased fertility and structural reproductive anomalies in male female mammals. While the activity profile of sex steroid hormone production distinctly differs developing males females, we wanted analyze sex-specific effects introduced utero via lactation on gonadal steroidogenesis gonadotropin levels rat infant pups. One oral dose (0, 0.04, 0.2, or 1.0 μg/kg) was given dams gestational day (GD) 13. Plasma testosterone,...
Abstract The protein tyrosine kinase (PTK) receptors and cytosolic signaling proteins as well the phosphatases (PTPs) have important roles in regulation of growth benign malignant prostate gland. Here, we studied expression phosphatase SHP‐1 cancer cell lines human prostatic tissues. is expressed at a high level LNCaP cells compared with PC3 cells. Silencing siRNA led to an increased rate proliferation, whereas overexpression by means transient stable transfection decrease proliferation....
Thyrotropin secretion from the anterior pituitary is regulated mainly through TRH and thyroid hormones. Recent findings of a TSH receptor (TSHR) on folliculo-stellate (FS) cells in human indicate that might, addition, be paracrine manner via FS cells. In order to elucidate physiological relevance TSHR expression we evaluated effects murine cell line, TtT/GF. First, Western blot analysis confirmed protein these Second, three potential second messenger pathways were studied. Last, cDNA array...
Testicular development is an androgen-dependent process, and fetal exposure to antiandrogens disrupts male sexual differentiation. A variety of testicular disorders may result from impaired Leydig Sertoli cells. We hypothesized that antiandrogenic during interferes with desert hedgehog (Dhh) signaling in the testis results cell Fetal rats were exposed utero antiandrogen flutamide 10.5 d post conception (dpc) until they killed or delivery. testes isolated at different time points gestation...
Antithyroid treatment for Graves' hyperthyroidism restores euthyroidism clinically within 1–2 months, but it is well known that TSH levels can remain suppressed many months despite normal free T4 and T3 levels. This has been attributed to a delayed recovery of the pituitary-thyroid axis. However, we recently showed pituitary contains receptor through which secretion may be down-regulated via paracrine feedback loop. In disease, autoantibodies also bind this receptor, thus causing continued...
Antithyroid treatment effectively restores euthyroidism in patients with Graves' hyperthyroidism. After a few months of treatment, are clinically euthyroid normal levels thyroid hormones, but many TSH remain suppressed. We postulated that receptor autoantibodies could directly suppress secretion, independently from hormone levels, via binding to the pituitary receptor. To test this hypothesis, we prospectively followed 45 hyperthyroidism who were treated antithyroid drugs. Three after...
Src homology 2 domain-containing tyrosine phosphatase-2 (SHP-2) is an important regulator of cell signaling because its ability to dephosphorylate receptors growth factors as well the cytokines and tyrosine-phosphorylated proteins associated with these receptors. In current study, we used four different prostate cancer lines: PC3, DU145, LNCaP LNCaP-IL6+. Tumor specimens from 122 patients were analyzed using a tissue microarray. Our data demonstrate that all lines express SHP-2 protein....
In the Western world, testicular germ cell cancer (TGCC) is most common malignancy of young men. The malignant transformation cells thought to be caused by developmental and hormonal disturbances, probably related environmental lifestyle factors because rapidly increasing incidence TGCC in some countries. Additionally, there a strong genetic component that affects susceptibility. However, polymorphisms have been identified so far only partially explain risk TGCC. Many persistent pollutants...
Adenohypophyseal-hormone production is regulated by hypothalamic peptides and target-gland hormones. Additionally, paracrine regulation folliculo-stellate cells within the pituitary has been suggested. We recently showed TSH receptor expression in human speculated that receptors for other adenohypophyseal hormones might also be expressed cells. Using RT-PCR, we evaluated of TSH, GH, ACTH, LH, FSH PRL a murine cell line, TtT/GF. Transcripts receptor, GH ACTH were detected this line. LH...