A5049288417- Muscle Physiology and Disorders
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Protease and Inhibitor Mechanisms
- Dietary Effects on Health
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Metabolism, Diabetes, and Cancer
- Coenzyme Q10 studies and effects
- ATP Synthase and ATPases Research
- Genomics, phytochemicals, and oxidative stress
- FOXO transcription factor regulation
- Adipokines, Inflammation, and Metabolic Diseases
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
University of Auckland
2019-2024
Harvard University
1995
What is the central question of this study? Does short-term high-intensity interval training alter composition microbiome and associated with exercise-induced improvements in cardiorespiratory fitness insulin sensitivity? main finding its importance? Although increased sensitivity cardiovascular fitness, it did not microbiome. This suggests that changes occur prolonged exercise might be response to metabolic health rather than driving training-induced adaptations.Regular reduces risk...
Loss of β-catenin impairs in vivo and isolated muscle exercise/contraction-stimulated glucose uptake. β-Catenin is required for exercise-induced skeletal actin cytoskeleton remodelling. β-Catenin675 phosphorylation during exercise may be intensity dependent.The conserved structural protein an emerging regulator vesicle trafficking multiple tissues supports insulin-stimulated transporter 4 (GLUT4) translocation by facilitating cortical Actin remodelling a convergence point between insulin...
Oxidative stress induced by acute exercise may regulate training-induced adaptations that improve metabolic health. One of the central transcription regulatory targets reactive oxygen species (ROS) is Nrf2 (nuclear factor erythroid-derived 2-like 2, or NFE2L2). Here, we investigated whether global deficiency in mice would impact changes glucose and lipid homeostasis. We report following 6 wk treadmill training, Nrf2-deficient have elevated fasting plasma triglycerides free fatty acids higher...
The human tropomyosin 3 (TPM3) gene was previously localized to chromosome 1. non-muscle isoform of the TPM3 product becomes fused a from tyrosine kinase receptor (NTRKl), 1q23→q24, generate an active oncogene. Two sequence tagged sites spanning three exons and two introns in carboxy coding region were used localize 1q22→q23 by fluorescence situ hybridization. This localization now places NTRKl genes close proximity, so that fusion rearrangement would not be cytologically detected. is within...
Neutrophils accumulate in peripheral tissues during obesity and are critical coordinators of tissue inflammatory responses. Here, we provide evidence that inhibition the primary neutrophil protease, elastase, with α1-antitrypsin A (A1AT) can improve insulin sensitivity glucose homeostasis mice fed a high-fat diet. This was attributed to improved insulin-induced IRS-1 phosphorylation white adipose provides further support for role neutrophils mediating diet-induced resistance.
Disuse-induced muscle atrophy is accompanied by a blunted postprandial response of the mammalian target rapamycin complex 1 (mTORC1) pathway. Conflicting observations exist as to whether postabsorptive mTORC1 pathway activation also disuse and plays role in atrophy. It unknown changes habitual protein intake alter regulatory proteins how they may contribute development anabolic resistance. The primary objective this study was characterize downstream responsiveness skeletal its upstream...
Interleukin-6 (IL-6) is produced and secreted by skeletal muscle cells during exercise plays an important role in mediating metabolic responses to exercise. The promoter region of the IL-6 gene contains a common genetic variant (-174 G/C, rs1800795) which may alter training. To isolate impact this on exercise-induced expression transcription following we generated knock-in mice with GG or CC genotype for murine homolog rs1800795. overall gross phenotype resting was similar between genotypes;...