A5071313494- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Genetic Neurodegenerative Diseases
- Metabolism, Diabetes, and Cancer
- Biomedical Research and Pathophysiology
- Neonatal Health and Biochemistry
- Amino Acid Enzymes and Metabolism
- Exercise and Physiological Responses
- Cardiovascular and exercise physiology
University of Auckland
2021-2022
Loss of β-catenin impairs in vivo and isolated muscle exercise/contraction-stimulated glucose uptake. β-Catenin is required for exercise-induced skeletal actin cytoskeleton remodelling. β-Catenin675 phosphorylation during exercise may be intensity dependent.The conserved structural protein an emerging regulator vesicle trafficking multiple tissues supports insulin-stimulated transporter 4 (GLUT4) translocation by facilitating cortical Actin remodelling a convergence point between insulin...
The lysosomal storage disease cystinosis is caused by mutations in CTNS, encoding the cystine transporter cystinosin, and its severest form leads to proximal tubule dysfunction followed kidney failure. Patients receive drug-based therapy cysteamine from diagnosis. However, despite long-term treatment, only slows progression of end-stage renal disease. Preclinical testing cystinotic rodents required evaluate new therapies; however, current models are suboptimal. To solve this problem, we...
The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples Pacific islands (including New Zealand Māori and Polynesia), with a frequency up 25% these populations. This associates large increase body mass index (BMI) but significantly lower risk type-2 diabetes (T2D). It remains unclear whether increased BMI driven by adiposity or lean mass. We undertook composition analysis using DXA 189 young men descent living Aotearoa Zealand. Further...
Unaccustomed exercise causes muscle damage resulting in loss of function, which may be attributable to exercise-induced increases skeletal reactive oxygen species. This study examined the effect mitochondria-targeted antioxidant supplementation on recovery function following exercise. Thirty-two untrained men received MitoQ (20 mg/day) or a placebo for 14 days before performing 300 maximal eccentric contractions knee extensor muscles 1 leg. Muscle was assessed using isokinetic dynamometry...
ABSTRACT The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples Pacific islands (including New Zealand Māori and Polynesia), with a frequency up 25% these populations. This associates large increase body mass index (BMI) but significantly lower risk type-2 diabetes (T2D). It unclear whether increased BMI driven by adiposity or lean mass. Hence, we undertook composition analysis using DXA 189 young men descent living Aotearoa Zealand. A was...