A5109577234- Heme Oxygenase-1 and Carbon Monoxide
- Vanadium and Halogenation Chemistry
- Amoebic Infections and Treatments
- Parasitic Infections and Diagnostics
- Amino Acid Enzymes and Metabolism
- Selenium in Biological Systems
- Neonatal Health and Biochemistry
- Plant tissue culture and regeneration
- Biomedical Research and Pathophysiology
- Transgenic Plants and Applications
- Parasitic infections in humans and animals
- Toxoplasma gondii Research Studies
- Peripheral Neuropathies and Disorders
- Curcumin's Biomedical Applications
- Reproductive System and Pregnancy
- Galectins and Cancer Biology
- Urban Stormwater Management Solutions
- Ocular Infections and Treatments
- Neurological diseases and metabolism
- Pharmacological Effects and Toxicity Studies
- Chromium effects and bioremediation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Legionella and Acanthamoeba research
- Chromatography in Natural Products
- Thyroid Disorders and Treatments
Northeastern University
1972-2024
University of Auckland
2021-2022
Fortis Hospital
2022
National Institute of Mental Health and Neurosciences
2021
National Hospital for Neurology and Neurosurgery
2019
University College London
2019
Boston University
2010-2017
University of Kentucky
2010-2017
University of Calcutta
2007-2010
Bose Institute
2006
Abstract Multiple system atrophy (MSA) is a fatal late-onset neurodegenerative disease. Although presenting with distinct pathological hallmarks, which in MSA consist of glial cytoplasmic inclusions (GCIs) containing fibrillar α-synuclein oligodendrocytes, both and Parkinson’s disease are α-synucleinopathies. Pathologically, can be categorized into striatonigral degeneration (SND), olivopontocerebellar (OPCA) or mixed subtypes. Despite extensive research, the regional vulnerability brain to...
The infectious and diagnostic stage of Giardia lamblia (also known as G. intestinalis or duodenalis) is the cyst. cyst wall contains fibrils a unique β-1,3-linked N-acetylgalactosamine (GalNAc) homopolymer at least three proteins (CWPs) composed Leu-rich repeats (CWPLRR) C-terminal conserved Cys-rich region (CWPCRR). Our goals were to dissect structure determine how it disrupted during excystation. intact thin (∼400 nm), easily fractured by sonication, impermeable small molecules. Curled...
Vanadium is a well recognized industrial hazard known to adversely affect male reproductive functions. The intricate mechanistic aspects of this metal and the role oxidative stress in deterioration testicular functions are investigated current study. experiment also focused on effects testosterone propionate sperm rat intoxicated with vanadate. exposure resulted more prominent spermatogenic arrest consistently abolished conversion round mature spermatids along decreased epididymal number...
Trichomonas vaginalis causes vaginitis and increases the risk of HIV transmission by heterosexual sex, while Tritrichomonas foetus premature abortion in cattle. Our goals were to determine effects, if any, anti-retroviral lectins, which are designed prevent HIV, on adherence ectocervical cells infections a mouse model. We show that Asn-linked glycans (N-glycans), like those bind mannose-binding lectin (MBL) is part innate immune system. N-glycans lectins (cyanovirin-N griffithsin) 2G12...
Giardia lamblia, the protist that causes diarrhea, makes an Asn-linked-glycan (N-glycan) precursor contains just two sugars (GlcNAc2) attached by a pyrophosphate linkage to polyprenol lipid. Because candidate cis-prenyltransferase of appears be more similar bacterial enzymes than those most eukaryotes and because is missing dolichol kinase (ortholog Saccharomyces cerevisiae SEC59 gene product), we wondered how synthesizes phosphate (Dol-P), which used make N-glycans...
The lysosomal storage disease cystinosis is caused by mutations in CTNS, encoding the cystine transporter cystinosin, and its severest form leads to proximal tubule dysfunction followed kidney failure. Patients receive drug-based therapy cysteamine from diagnosis. However, despite long-term treatment, only slows progression of end-stage renal disease. Preclinical testing cystinotic rodents required evaluate new therapies; however, current models are suboptimal. To solve this problem, we...
ABSTRACT Transition metal vanadium has been shown to modulate the cellular redox potential and catalyze generation of reactive oxygen intermediates. Since free radical production lipid peroxidation are potentially important mediators in testicular physiology pathophysiology, present study was conducted elucidate vanadium-induced oxidative damages rat testis ameliorative role zinc sulphate against such adverse effects vanadium. Adult male rats were dosed for 26 days with daily intraperitoneal...
Background Blindness is caused by eye pathogens that include a free-living protist (Acanthamoeba castellanii, A. byersi, and/or other Acanthamoeba spp.), fungus (Fusarium solani), and bacterium (Chlamydia trachomatis). Hand-eye contact likely contributor to the spread of these pathogens, so hand washing with soap water or alcohol–based sanitizers (when not available) might reduce their transmission. Recently we showed ethanol isopropanol in concentrations present kill walled cysts Giardia...
Objective For efficient biofarming we attempted to enrich plant interstitial fluid (IF)/apoplastic with targeted recombinant therapeutic protein. We employed a synthetic human Glucocerebrosidase (GCB), model biopharmaceutical protein gene in this study. Results Twenty one Nicotiana varieties, species and hybrids were initially screened for individual IF recovery based on the findings, selected tabacum NN (S‐9‐6), nn (S‐9‐7) benthamiana (S‐6‐6) as plants raising transgenic expressing GCB via...
ABSTRACT Enteric protozoan parasites, which are spread by the fecal-oral route, important causes of diarrhea ( Giardia duodenalis ) and amebic dysentery Entamoeba histolytica ). Cyst walls have a single layer composed fibrils β-1,3-linked GalNAc β-1,4-linked GlcNAc (chitin), respectively. The goal here was to determine whether hand sanitizers that contain ethanol or isopropanol as active microbicide might reduce transmission these parasites. We found treatment with alcohols without drying in...
The limited amount of data available renders it challenging to characterize which biological processes are relevant a rare disease. Hence, there is need leverage the knowledge disease pathogenesis and treatment from wider landscape understand mechanisms. Furthermore, well understood that discoveries can inform our common diseases. In this paper, we introduce Dis2Vec (Disease Vector), new representation learning method for characterizing diseases with focus on underlying mechanisms, step...
Abstract Background The lysosomal storage disease cystinosis is caused by mutations in CTNS , encoding a cystine transporter, and its severest form leads to proximal tubule dysfunction followed kidney failure. Patients receive the drug-based therapy cysteamine from diagnosis. However, despite long-term treatment, only slows progression of end-stage renal transplant inevitable. Pre-clinical testing cystinotic rodents required evaluate new therapies; however, current models are sub-optimal. To...