A5033157419- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Estrogen and related hormone effects
- Radiopharmaceutical Chemistry and Applications
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Hormonal and reproductive studies
- Molecular Biology Techniques and Applications
- Vascular Tumors and Angiosarcomas
- Tannin, Tannase and Anticancer Activities
- Lung Cancer Research Studies
- Cardiac Imaging and Diagnostics
- Nutrition and Health in Aging
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cardiac tumors and thrombi
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Neurofibromatosis and Schwannoma Cases
Institut Gustave Roussy
2017-2024
Inserm
2023-2024
Université Paris-Saclay
2019-2024
Istituto Ortopedico Rizzoli
2024
Prédicteurs moléculaires et nouvelles cibles en oncologie
2023
Saint Joseph University
2013-2020
Université Paris-Sud
2019
Hôtel-Dieu de France
2015-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2017
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2017
BackgroundInfarct size is an important predictor of cardiac risk after acute myocardial infarction. The established modality for its assessment Tc99m-Sestamibi Single-photon emission computed tomography (SPECT). In recent years, data are emerging demonstrating that scar as assessed by late gadolinium enhancement in cardiovascular magnetic resonance imaging (CMR) well the presence microvascular obstruction (MO) may also provide prognostic information, however, so far no direct comparisons...
The androgen receptor axis inhibitors (ARPI; e.g., enzalutamide, abiraterone acetate) are administered in daily practice for men with metastatic castration-resistant prostate cancer (mCRPC). However, not all patients respond, and mechanisms of both primary acquired resistance remain largely unknown.In the prospective trial MATCH-R (NCT02517892), 59 mCRPC underwent whole-exome sequencing (WES) and/or RNA (RNA-seq) samples collected before starting ARPI. Also, 18 biopsy at time resistance....
Evaluation of bone marrow involvement (BMI) is paramount in diffuse large B-cell lymphoma (DLBCL) for prognostic and therapeutic reasons. PET/CT scanner (PET) now a routine examination the staging DLBCL with implications. This study evaluates role PET detecting compared to biopsy (BMB). monocentric included 54 patients diagnosed between 2009 2013 who had FDG pre-treatment setting. A correlation analysis detection BMI by BMB was performed. evaluation and/or an overall 2-year survival were...
Background Our aim was to explore the prognostic value of anthropometric parameters in a large population patients treated with immunotherapy. Methods We retrospectively included 623 advanced non-small cell lung cancer (NSCLC) (n=318) or melanoma (n=305) by an immune-checkpoint-inhibitor having pretreatment (thorax-)abdomen-pelvis CT scan. An external validation cohort 55 NSCLC used. Anthropometric were measured three-dimensionally (3D) deep learning software (Anthropometer3DNet) allowing...
With the emergence of novel targeted therapeutic options in early-stage and advanced-stage malignancies, researchers have shifted their focus on developing personalized treatment plans through molecular profiling. Circulating tumor DNA (ctDNA) is a cell-free fragment, originating from cells, circulating bloodstream as well biological fluids. Over past decade, many techniques were developed for liquid biopsies next-generation sequencing. This alternative non-invasive biopsy offers several...
Brain metastases (BM) are rare in colorectal cancer (CRC) and associated with a dismal prognosis. This work aims to report the rate of BM CRC patients treated single institution, along survival prognostic factors.Medical charts for histologically proven were retrospectively reviewed.A total 538 identified, whom 33% developed any metastatic disease 4.4% presented BM. Lung was most frequently site (in 68% cases). The only factor independently development presence at time initial presentation....
The fibroblast growth factor receptor 3 (FGFR3) plays critical roles in driving oncogenesis of a subset patients with urothelial carcinomas (UC).Growing evidence from preclinical studies suggests that FGFR3 inhibition can reduce proliferation and survival vitro vivo models FGFR3-altered UC.Early clinical trials investigating selective inhibitor have reported preliminary signs antitumor activity advanced UC selected mutations or fusions.Currently, phase erdafitinib rogaratinib are enrolling...
The few studies of the molecular biology colorectal cancer (CRC) in Middle Eastern populations have included only small samples patients.Evaluate frequency and prognostic effect RAS, BRAF, PIK3CA, PTEN, EGFR somatic mutations as well mismatch repair (MMR) deficiency Lebanese patients.Retrospective single-center descriptive study.Lebanese patients a tertiary medical cen.ter.We all diagnosed with CRC between January 2010 December 2015, whom RAS mutational status expression MLH1 MSH2 proteins...
The most recent progress in the oncology field has led to a paradigm shift management of cancer with tsunami immune checkpoint inhibitors that are associated particular pattern immunological adverse events. This is case 54-year-old woman demonstrated granulomatous reaction same dermatomal distribution previously treated shingles infection during treatment an anti-programmed death 1 agent (pembrolizumab) for newly diagnosed stage IV Hodgkin lymphoma. purpose this increase awareness...