A5070018175- Testicular diseases and treatments
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Renal and related cancers
- Epigenetics and DNA Methylation
- Immunodeficiency and Autoimmune Disorders
- Ovarian cancer diagnosis and treatment
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- DNA Repair Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cardiac tumors and thrombi
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Circular RNAs in diseases
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Gastric Cancer Management and Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Ear and Head Tumors
Hospital de Câncer de Barretos
2016-2025
Administração Regional de Saúde de Lisboa e Vale do Tejo
2023
AC Camargo Hospital
2002-2023
Children Cancer Hospital
2023
Hospital São Paulo
1991-2020
Hospital Santa Marcelina
2009-2016
Universidade de São Paulo
2003-2016
Support group for adolescents and children with cancer
2016
Dana-Farber Cancer Institute
2003-2015
Heinrich Heine University Düsseldorf
2012
Preoperative intraarterial (IA) cisplatin (CDP) was administered to 92 patients with nonmetastatic osteosarcoma. The ages of the ranged from 4 28 years. Sixty-four (70%) received 2 or 3 preoperative courses and (30%) more. Sixty-two specimens were available for pathologic examination assess degree tumor necrosis. More than 90% destruction observed in 16 42 (38%) who 1 as opposed 17 20 (85%) more courses. Patients had a 2-fold probability achieving necrosis, 68% underwent conservative...
PURPOSE To describe event-free survival (EFS) and toxicities in children with low-risk acute lymphoblastic leukemia (ALL) assigned to receive either continuous 6-mercaptopurine (6-MP) weekly methotrexate (MTX) or intermittent 6-MP intermediate-dose MTX, as maintenance treatment. PATIENTS AND METHODS Between October 1, 2000, December 31, 2007, 635 patients ALL were enrolled onto Brazilian Childhood Cooperative Group for Treatment (GBTLI) ALL-99 protocol. Eligible (n = 544) randomly allocated...
Osteosarcoma (OS) is the most common primary bone cancer in childhood. OS an aggressive disease, and metastatic patients evolve with very poor clinical outcomes. Genetically, OSs are extremely complex tumors, related process not well understood terms of biology disease. In this context, long non-coding RNAs (lncRNAs) have emerged as important class gene expression regulators that play key roles invasion metastasis several human tumors. Here, we evaluated HULC, which lncRNA associated tumor...
Testicular germ cell tumors (TGCT) represent the second main cause of cancer-related death in young men. Despite high cure rates, refractory disease results poor prognosis. Epigenetic reprogramming occurs during development seminomas and non-seminomas. Understanding molecular genetic basis these would an important advance search for new TGCT markers. Hence frequency methylation a gene panel (VGF, MGMT, ADAMTS1, CALCA, HOXA9, CDKN2B, CDO1 NANOG) was evaluated 72 primary by quantitative...
Journal Article Parental Exposures to Pesticides and Risk of Wilms' Tumor in Brazil Get access Colin R. Sharpe, Sharpe 1Departments Epidemiology Biostatistics, ArmandFrappier Institute McGill UniversityMontreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Eduardo L. Franco, Franco Reprint requests Dr. Institut Armand Frappier, 531 Des Prairies Blvd., Laval, Quebec H7N 4Z3, Beatriz de Camargo, Camargo 2Department Pediatric Oncology, A. C. HospitalSao...
Testicular Germ Cell Tumors (TGCTs) are a rare group of neoplasms and the most common solid malignancy arising in young male adults. Despite good response these tumors to platinum-based chemotherapy, some patients refractory treatment present poor clinical outcomes. During carcinogenesis tumor development, cancer cells reprogram energy metabolism towards hyper-glycolytic phenotype, an emerging hallmark cancer. This phenomenon, known as Warburg effect or aerobic glycolysis, involves...
Mortality from childhood leukemia has declined substantially in developed countries but less markedly the developing world. This study was designed to describe mortality trends and impact of social inequalities on these Brazil 1980 2002.Cancer data by cause estimates resident population stratified age sex were obtained Brazilian Information System (SIM) for years 2002. Age-standardized (ages 0-19 years) rates calculated direct method using 1960 world standard population. Trends modeled...
In 1988, we formed a consortium of Brazilian institutions to develop uniform standards for the diagnostic assessment and multidisciplinary treatment children adolescents with germ cell tumors. We also implemented first childhood tumor protocol, GCT-91, evaluating two-agent chemotherapy cisplatin etoposide (PE). now report on clinical characteristics survival tumors treated this protocol.From May 1991 April 2000, 115 patients (106 assessable patients) were enrolled onto protocol diagnosis...
There is currently a global shortage of healthcare professionals equipped to handle the rising burden childhood cancer. St. Jude Global an initiative improve survival rates children with cancer worldwide while improving access quality care. One overriding goals focused on education: training clinical workforce needed expand care for all Herein, we describe Academy (SJGA) and its programs. The three main workstreams SJGA are: programs, courses, distance learning. collaborates eight...
Abstract Introduction Central nervous system (CNS) tumors are the most common solid in childhood, comprising 20% of all neoplasms that age. Besides, they constitute biggest cause morbidity and mortality among childhood tumors, about two thirds surviving patients have sequelae. The build-up sequelae due to neoplastic growth is directly related with time until diagnosis. Therefore, late diagnosis has a negative influence on prognosis. Objective To analyze journey pediatric CNS their families...
Introdução: O câncer corresponde à proliferação anormal de células e, embora possa ser considerado raro em crianças, adolescentes e adultos jovens, constitui a primeira causa mortalidade por doença até os 29 anos. Objetivo: Investigar características epidemiológicas pacientes famílias, Regiões do Estado São Paulo, com análise contextual primeiro atendimento das dificuldades chegada ao Hospital Câncer Infantojuvenil Barretos. Métodos: Estudo transversal, ambispectivo, janeiro 2015 2023, uso...
The aim of this study was to evaluate the frequency polymorphisms in TYMS, XRCC1, and ERCC2 DNA repair genes pediatric patients with acute lymphoblastic leukemia using polymerase chain reaction (PCR) PCR-restriction fragment length polymorphism (RFLP) approaches. conducted 206 364 controls from a Brazilian population. No significant differences were observed among analyzed groups regarding XRCC1 codon 399 194 751 312 polymorphisms. TYMS 3R variant allele significantly associated reduced risk...
We describe the results of a risk-adapted, response-based therapeutic approach from Brazilian GCT-99 study on germ cell tumors.From May 1999 to October 2009, 579 participants were enrolled in study. Treatment, defined as specific chemotherapy regimen and number cycles, was allocated by means risk-group assignment at diagnosis with consideration for stage primary tumor site. Patients low risk received no chemotherapy. intermediate (IR) good response (GR) four cycles platinum etoposide (PE),...
Mutations of the tumor suppressor gene p53 are commonly found in several kinds human cancer. In some types neoplasms, accumulation protein has been reported to correlate with more aggressive clinical behavior. The role expression Wilms tumors (WT) is not clear yet, but most studies have confirmed its correlation anaplasia and advanced stage disease.Ninety-seven WT were evaluated for by immunohistochemistry formalin-fixed paraffin-embedded tissue correlated outcome. Tumors classified as...
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV associated with infectious mononucleosis human cancers, including some lymphomas gastric carcinomas. Although was first reported in lymphoepithelioma-like carcinoma, the also found conventional adenocarcinomas. In present study, 53 carcinomas diagnosed São Paulo State, Brazil, were evaluated for by non-isotopic situ hybridization biotinylated probe...
Testicular germ cell tumors (TGCT) are the most common malignant neoplasm in young men. DNA mismatch repair deficiency can lead to microsatellite instability (MSI), an important mechanism of genetic instability. A mutation BRAF gene has been implicated pathogenesis several solid and recently become therapeutic target. The role MSI TGCT, particularly refractory disease, is poorly understood reported findings controversial. In this study, we aimed determine frequency clinical impact status...