A5002406760- Protein Hydrolysis and Bioactive Peptides
- Protein Interaction Studies and Fluorescence Analysis
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
- Meat and Animal Product Quality
- Natural Antidiabetic Agents Studies
- Food composition and properties
- Nanoparticle-Based Drug Delivery
- Phytochemicals and Antioxidant Activities
- Advanced Technologies in Various Fields
- Food Quality and Safety Studies
- Ruminant Nutrition and Digestive Physiology
- Free Radicals and Antioxidants
- Collagen: Extraction and Characterization
- Phytochemistry and biological activity of medicinal plants
- French Urban and Social Studies
- Competency Development and Evaluation
- Natural product bioactivities and synthesis
- Aluminum toxicity and tolerance in plants and animals
- melanin and skin pigmentation
- Engineering Education and Curriculum Development
- Seaweed-derived Bioactive Compounds
- Biochemical and Structural Characterization
- Marine Invertebrate Physiology and Ecology
- Safety and Risk Management
Henan University of Science and Technology
2008-2025
Zhejiang Wanli University
2007-2022
Luoyang Institute of Science and Technology
2019
Nanjing University
2008-2011
Ocean University of China
2007-2009
In this study, a novel peptide GPPGPA was screened from the collagen hydrolysates of Chinese giant salamander (Andrias davidianus) skin, and its anti-diabetes mechanism predicted by network pharmacology, an inhibitory effect on α-glycosidase protective IR (insulin resistance) oxidative stress IR-HepG2 cells were detected. Through pharmacology screening, found to have good drug-like properties, 103 targets overlap with T2DM targets. These mainly enriched in PI3K-Akt signaling pathway...
There is a growing demand for natural and potent α-glucosidase inhibitors due to the rising prevalence of diabetes. In this study, newly identified inhibitory peptides were from tryptic hydrolysate hemp seed proteins based on peptidomics in silico analysis. A total 424 peptides, primarily derived four cupin-type-1 domain-containing proteins, identified, 13 ultimately selected validation their higher PeptideRanker scores, solubility, non-toxicity, favorable ADMET properties. Molecular docking...
The molecular mechanism of the interaction between resveratrol and trypsin was studied using fluorescence spectroscopy (intrinsic fluorescence, synchronous three-dimensional fluorescence), ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infrared (FT-IR) docking method, as well through enzyme activity antioxidant assay. experiments (the Stern-Volmer quenching constants (KSV)) indicated that quenched intrinsic static mechanism. number binding sites about one. thermodynamic...
Natural and potent tyrosinase inhibitors are in high demand the food, cosmetic, pharmaceutical industries. In this study, hydrolysate was prepared from peony (Paeonia ostii) seed meal proteins (PSMP) by Neutrase with inhibitory activity. The peptide profile analysis exhibited that there were 594 peptides 28 proteins, among which 39 predicted to have bioactivity, good solubility, non-toxicity, suitable for oral or topical administration silico analysis. Molecular docking demonstrated 38 of...
A strategy to manipulate the disulfide bond breaking triggered unfolding, and subsequently assembly of human serum albumin (HSA) in a lipophilic drug-dependent manner is present. In this study, hydrophobic region, molecular switch HSA, was regulated form HSA-paclitaxel (HSA-PTX) nanoparticles by facile route. High-resolution transmission electron microscopy fluorescence quenching indicate that HSA coassembled with PTX, which acts as bridge core-shell about 50-240 nm size, PTX might bind...
In this study, we examined the effect of xylooligosaccharide (XOS) supplementation on growth performance, carcass characteristics, and meat quality Hu lambs. total, 60 lambs (two months old weighing 17.32 ± 0.81 kg) were randomly assigned to four treatment groups, each with three replicates five per replicate. The fed basal diets supplemented 0, 1.5, 3, or 4.5 g/kg XOSs in a diet for days, groups designated XOS0%, XOS1.5%, XOS3%, XOS4.5%, respectively. results revealed, compared theXOS0%...
A two-stage simulated gastro-intestinal (GI) digestion model (2 h pepsin treatment and subsequent 2 pancreatin at 37 °C) was used to explore the antioxidant activity of digested products Cyprinus carpio haematopterus scale gelatin with different molecular weights (MW). From gastric phase intestinal phase, hydrolysis degree increased from 2.6 ± 0.4% 16.9 0.7%. The fraction 0–1 kDa (JCP3) exhibited best activities in hydroxyl radical scavenging, reducing power, metal chelating activity. 1–3...
The molecular mechanism of interaction between aloe-emodin (AE) and trypsin was investigated, exhibiting remarkable outcomes. To detect the mechanism, binding AE with examined by a multi-spectroscopy docking method. Results showed that would lead to static quenching their forces were van der Waals hydrogen bonding. results simultaneous three-dimensional fluorescence spectroscopy combination caused changes in microenvironment around fluorophore, which might change spatial structure trypsin....
This paper adopts a deep learning approach to analyze and study the mechanism of quantitative enhancement college students’ employment entrepreneurial abilities in context digital era. The connotation is predetermined as five abilities, which are metacognitive ability, active communication cooperation processing creative practice empathy experience, and, based on this, questionnaire designed, it reclassified by exploratory factor analysis reduce dimensionality, specific indicators scientific...
E-commerce and the development of modern enterprise management raise a number challenges in process informatization small medium-sized enterprises (SME) china. To address this, we present an approach which is enhanced by using Open Source Software with customized policies. We analyses main informationization obstacles SME china, bring forward that lack bankroll, talents, cost etc. are key problems to SME. Furthermore, have developed textile foreign trade ERP /CRM system based on for local...
In recent years, the employment of college students is becoming more and prominent; no matter for society, universities, themselves, their families have formed a huge pressure, in current situation, success rate to start own business not high; one important reasons that generally defects entrepreneurial psychology. Therefore, effective evaluation students' mental health under environment independent entrepreneurship conducive comprehensively improving quality talent training colleges...
As the primary industry, agriculture is a prerequisite for human survival and basic industry of national economy. result, growth vital nation’s socioeconomic development. The construction ecological civilization reform innovation farmers’ digital entrepreneurial behavior in region are intimately correlated with agricultural eco‐environmental quality. Therefore, it crucial us to improve control maintenance eco‐environment. A requirement directing sustainable economy evaluating identifying...
The third generation mobile systems will be set up in the future not far China, there are a number of challenges e-business small and medium-sized enterprises (SME). To address this, we present solution that is enhanced by using external electronic security key special authentication protocols. Furthermore, have developed textile foreign trade system based on open source software for local distributor China integrating financial, distribution, sales service processes, given implement method...
In the western Henan agricultural area, Duhu (Dupo♂ × Hu sheep♀) hybrid lambs are primary breed of local meat sheep, predominantly raised in large-scale indoor feeding systems, although many farmers still rely on grazing. However, limited research exists quality under both grazing and systems. This study examined how affect nutritional quality, flavor, amino acid profile, fatty composition 7-month-old lamb meat. Grazed exhibited significantly (