A5101879633- Asymmetric Synthesis and Catalysis
- Asymmetric Hydrogenation and Catalysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Magnetic properties of thin films
- Magnetic Properties and Applications
- Magnetic Properties of Alloys
- Synthetic Organic Chemistry Methods
- Cancer therapeutics and mechanisms
- Axial and Atropisomeric Chirality Synthesis
- Cyclopropane Reaction Mechanisms
- Chromatography in Natural Products
- Crystallography and molecular interactions
- Fluorine in Organic Chemistry
- Surface Chemistry and Catalysis
Jilin University
2010-2021
Jilin Medical University
2017-2018
Southwest University of Science and Technology
2012
A novel bifunctional phase-transfer catalyst <bold>1i</bold> was found to be highly efficient for the nitro-Mannich reaction of unactivated ketone-derived imines with introduction protecting group 6-methyl-2-pyridylsulfonyl ketimines. Density functional theory (DFT) calculations are also performed give possible transition-state model.
N,N'-Acetals are sensitive compounds, and the challenging asymmetric synthesis of acyclic N,N'-acetals by general addition amines to ketimines has never been reported so far. In this study, highly enantioselective aryl isatin-derived catalyzed chiral urea derived from quinine was developed. A series new were constructed protocol in high excellent yields (78-99%) enantioselectivities (76-96% ee).
A series of bifunctional asymmetric phase-transfer catalysts containing novel fluorine-containing urea groups derived from cinchona alkaloids have been synthesized and successfully applied in the intramolecular Mannich reaction. The 4-azaindoline products bearing multiple substrates were obtained excellent yield (90−99%), with high enantioselectivity (up to 95%) diastereoselectivity >99:1).
A homogeneous organocatalyst for asymmetric reduction of imines can be reused several cycles through a self-assembly method using MNPs.
A series of chiral thiourea bearing multiple H-bond donors derived from hydroquinine has been reported. The aza-Henry reaction isatin-derived ketimines and long-chain nitroalkanes catalyzed by these thioureas can achieve high enantioselectivity (78–99% ee) excellent diastereoselectivity (up to 99:1). This work is the first report on as substrates with in metal-free catalytic systems.
A series of 3-substituted 3-amino-oxindoles were constructed in excellent yields (96–99%) with high enantioselectivities (up to 95% ee) and diastereoselectivities 95 : 5 dr) catalyzed by Cinchona alkaloid-derived phase-transfer catalysts.
A series of 3-substituted 3-amino-oxindoles were constructed by this protocol in excellent yields (92–99%) with high enantioselectivities (85–99% ee) and diastereoselectivities (up to >99 : 1 dr).
Abstract Chiral phase-transfer catalysts derived from tert-leucine were synthesized and used in the asymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers corresponding products obtained excellent yield (up to 99%) with high enantioselectivities 91% ee) diastereoselectivities >99: 1 dr).