A highly efficient Pd(OAc)2/guanidine aqueous system for the room temperature Suzuki cross-coupling reaction has been developed. The new water-soluble and air-stable catalyst Pd(OAc)2.(1f)2 from Pd(OAc)2 1,1,3,3-tetramethyl-2-n-butylguanidine (1f) was synthesized characterized by X-ray crystallography. In presence of Pd(OAc)2.(1f)2, coupling arylboronic acids with a wide range aryl halides, including iodides, bromides, even activated chlorides, carried out smoothly in solvent to afford...

Abstract Parkinson’s disease (PD) is a common neurological disorder characterized by dopaminergic (DA) neuron degeneration and death in the midbrain, long noncoding RNA HOTAIR has been shown to affect progression PD. In this study, we aimed further illustrate molecular mechanism of Bioinformatics analysis was utilized determine potential downstream targets Luciferase assay Binding Protein Immunoprecipitation (RIP) were used validate existence binding sites between competing endogenous RNAs...

Brønsted acid−base ionic liquids (GILs) based on guanidine and acetic acid are efficient reaction media for palladium-catalyzed Heck reactions. They offer the advantages of high activity reusability. GIL2 plays multiple roles in reaction: it could act as solvent, a strong base to facilitate β-hydride elimination, ligand stabilize activated Pd species.

The synthesis and characterization of carbon-coated ferromagnetic nanoparticles that organize into 1-D assemblies micrometer-sized chains is described. A controlled aromatization carbonization glucose under hydrothermal reaction conditions enabled the preparation carbonaceous surfactants were used as shells for coating Fe(3)O(4) nanospheres with a uniform size distribution. Under experimental conditions, it was, first time, demonstrated could be employed carbon source in continuous...

Bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors have rarely been explored. The first quaternary ammonium type of these derived from cinchona alkaloids were readily prepared and found to be highly efficient for nitro-Mannich reactions amidosulfones. Compared with previous reports, very broad substrate generality was observed, both enantiomers the products achieved in high enantio- diastereoselectivity (90–99% ee, 13:1 99:1 dr).

A facile and convenient synthesis of substituted pyridines has been developed via a one-pot multicomponent reaction easily available 1,3-dicarbonyl compounds, aromatic aldehydes, malononitrile alcohol in the presence NaOH under mild conditions. series functionalized were thus obtained by this reaction, which four new bonds formed highly chemo- regioselective manner, played dual roles as both reactant medium. Particularly valuable features protocol including conditions, simple execution,...

CD133, a member of the prominin family, is found in variety tissues with at least three variants. The function CD133 not well understood, but its expression subject to changes microenvironment cues including bioenergetic stress. Knockout does affect renewal, mammary gland branching. A point mutation (R733C) leads retinal disorder. embryonic stem cells, normal tissue cell niches, and circulating endothelial progenitors as cancer cells. Maintenance stemness may be attributable asymmetric...

Abstract A protocol for the copper‐mediated direct aryl CH halogenation is presented. Highly selective mono‐ and di‐halogenations are achieved by using acyl hypohalites, generated in situ from readily available carboxylic acid N ‐halosuccinimides (NXS; X=Br Cl) as powerful halogenating reagents. The correct choice of additives solvents essential both high yield selectivity. Consequently, use inexpensive Cu catalyst new strategy generation hypohalite reagents affordable easily‐to‐handle NXS...

A facile and efficient synthesis of polysubstituted benzenes has been developed via sequential Michael addition, Knoevenagel condensation nucleophilic cyclization reactions readily available chalcones with active methylene compounds in guanidinium ionic liquids.

Abstract We present a highly active, inexpensive, universally applicable, and markedly stable [1,3‐bis(diphenylphosphino)propane]nickel(II) chloride [Ni(dppp)Cl 2 ] catalyst that is capable of effecting the Suzuki–Miyaura cross‐coupling inherently less reactive but readily available aryl tosylates mesylates with only 1 mol% loading in absence extra supporting ligand. Under optimized reaction conditions, wide range activated, non‐activated, deactivated, as well sterically hindered...

An efficient enantioselective aza-Henry reaction of aryl α-ketoester-derived ketimines has been realized by using bifunctional thiourea–ammonium salt phase-transfer catalysts, which were derived from quinine. A variety N-Ts investigated, and the corresponding products obtained in high to excellent yields (up 99%) with good enantioselectivities >99% ee).

A novel bifunctional phase-transfer catalyst <bold>1i</bold> was found to be highly efficient for the nitro-Mannich reaction of unactivated ketone-derived imines with introduction protecting group 6-methyl-2-pyridylsulfonyl ketimines. Density functional theory (DFT) calculations are also performed give possible transition-state model.

A novel multichannel dilated convolution neural network for improving the accuracy of human activity recognition is proposed. The proposed model utilizes structure with multiple kernels various sizes to extract multiscale features high-dimensional data during operation and not consider use pooling layers that are used in traditional convolution. Its advantage can first capture intrinsical sequence information by expanding field kernel without increasing parameter amount model. And then, be...

A highly enantioselective aza-Friedel-Crafts reaction of 1H-indoles with isatin-derived N-Cbz-ketimines catalyzed by quinine-derived phase-transfer catalysts was developed. series chiral 3-aminobisindole compounds containing a tetrasubstituted stereocenter were constructed this protocol in high yields (82-91%) and moderate to excellent enantioselectivities (46-94% ee).

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The provides facile practical synthesis pyrrolo[2,1-a]isoquinolines. A number pyrrolo[2,1-a]isoquinolines were synthesized moderate to high yields (up 97%).

A supercritical fluid method has been developed to prepare hydrothermally stable, high quality mesoporous MCM-48 materials. Pure silica materials were post-treated by carbon dioxide containing a small amount of aluminum tri-sec-butoxide (sc-CO2/Al). The hydrothermal stability these treated in boiling water was studied powder X-ray diffraction, nitrogen absorption analysis, transmission electron microscopy, and 29Si 27Al MAS NMR. NMR studies suggest that incorporation the tetrahedral Al atoms...

A high-yield, highly diastereo- and enantioselective nitro-Mannich reaction of α-aryl nitromethanes with amidosulfones catalyzed by a novel chiral phase-transfer catalyst, bearing multiple H-bonding donors, derived from quinine was developed. variety were investigated; the corresponding products obtained in excellent yields enantioselectivities (up to 99% yield, > 99:1 dr >99% ee). As demonstration synthetic utility, resulting β-nitroamines could be converted meso-symmetric optically pure...

The squaramide moiety has proven to be a powerful hydrogen-bonding donor in organocatalysis, but chiral phase-transfer catalysts bearing the motif have not been reported so far. Reported herein is this kind of catalyst and their catalytic performance asymmetric fluorination β-keto esters.