A series of 1,2,3-triazole-bound cationic Au(I) catalysts have been synthesized, and their structures characterized by X-ray crystallography. Variable-temperature NMR studies revealed dynamic triazole-Au cation coordination in solution. Reaction profiles clearly indicated that these new possess much better thermal stability than literature-reported Au catalysts, including IPrAu x NTf(2). By application challenging intermolecular hydroaminations were achieved with less-reactive internal...

Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes these were found to have extremely high activities (S/C up 100 000) and enantioselectivities (ee 99.5%) in the asymmetric hydrogenation aromatic, heteroaromatic, α,β-unsaturated ketones.

The enantioselective copper(II)-catalyzed Friedel−Crafts addition of indoles to N-sulfonyl aldimines was developed using chiral bisoxazoline as ligands, and high enantioselectivities (up 96% ee) were achieved.

A highly efficient nickel-catalyzed asymmetric reductive coupling of dienes and aldehydes has been realized by using bulky spirobiindane phosphoramidite ligands, affording bishomoallylic alcohols in high yields with excellent diastereoselectivities enantioselectivities.

[reaction: see text] Highly efficient rhodium-catalyzed asymmetric addition of arylboronic acids to aldehydes has been realized by using chiral spiro monophosphite ligands, affording diarylmethanols in excellent yields and good enantiomeric excesses.

The asymmetric arylation of N-tosylarylimines with arylboronic acids was realized by using rhodium/(S)-ShiP as catalyst. reaction proceeded in aqueous toluene to give diarylmethylamines good yields up 96% ee. [reaction: see text]

Rhodium catalysis: The first example of a catalytic asymmetric addition arylboronic acids to α-ketoesters was realized by using chiral RhI–spirophosphite ligand complex in aqueous solvent provide tertiary α-hydroxyesters good yields with high enantioselectivities (see scheme; DCE=1,2-dichloroethane).

A Lewis base-catalyzed three-component cascade reaction was developed for the synthesis of 4,5-disubstituted-1,2,3-(NH)-triazoles. More than 25 new (NH)-triazoles were prepared in good to excellent yields under mild conditions. The availability C-4 vinyl group allows easy conversion into other triazole derivatives.

The synthesis and characterization of carbon-coated ferromagnetic nanoparticles that organize into 1-D assemblies micrometer-sized chains is described. A controlled aromatization carbonization glucose under hydrothermal reaction conditions enabled the preparation carbonaceous surfactants were used as shells for coating Fe(3)O(4) nanospheres with a uniform size distribution. Under experimental conditions, it was, first time, demonstrated could be employed carbon source in continuous...

A catalytic cascade synthesis of isoxazoline-N-oxide was developed through proline-catalyzed nitroalkene activation. large substrate scope obtained with good to excellent yields. Mechanistic studies revealed intramolecular cyclization as the rate-determining step, giving only trans isomers in all cases.

A facile and efficient synthesis of polysubstituted benzenes has been developed via sequential Michael addition, Knoevenagel condensation nucleophilic cyclization reactions readily available chalcones with active methylene compounds in guanidinium ionic liquids.

On the sunny side: A homogeneous system for H2 production and hydrocarbon oxidation was developed in absence of any sacrificial reagent. This consists [Ru(TPA)(H2O)2]2+ [Fe3(CO)12] as catalysts [Ru(bpy)3]2+ [Ir(bpy)(ppy)2]+ photosensitizers (PS). Water is oxygen source well formation (see picture; Sub=organic substrate). Detailed facts importance to specialist readers are published ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available...

A highly enantioselective aza-Friedel-Crafts reaction of 1H-indoles with isatin-derived N-Cbz-ketimines catalyzed by quinine-derived phase-transfer catalysts was developed. series chiral 3-aminobisindole compounds containing a tetrasubstituted stereocenter were constructed this protocol in high yields (82-91%) and moderate to excellent enantioselectivities (46-94% ee).

The Ru(II) complexes of SDP and DPEN combined with t-BuOK in 2-propanol formed a very effective catalyst for the hydrogenation simple aromatic ketones high activity enantioselectivity. racemic alpha-arylcycloalkanones can also be hydrogenated by this system, providing alpha-arylcycloalkanols excellent cis/trans stereoselectivity (>99:1) enantioselectivity (up to 99.9%) cis isomer. In study effect alkali metal cation acetophenone using RuCl(2)(Tol-SDP)(DPEN) RuCl(2)(Xyl-SDP)(DPEN) catalysts,...

4,5-Disubstituted NH-1,2,3-triazoles (TRIA) were used to coordinate with Rh(I) metal cation, forming a new class of triazole-bridged [Rh(COD)(TRIA)]2 complexes in near-quantitative yields. X-ray crystallography studies revealed that the C-4-substituted groups effectively controlled triazole binding sites, resulting different coordination patterns. In addition, these air- and moisture-stable showed effective catalytic properties Pauson−Khand reactions, superior stability.

Abstract The epidermal growth factor receptor (EGFR) family belongs to type I tyrosine kinases. Overexpression or mutation of EGFR/ErbB1 gene has been detected in a large number human solid tumours. According some previous report, this is not expressed hematological malignancies. However, two recent clinical case reports showed that erlotinib caused complete remission acute myeloid leukaemia (AML)‐M1 patients who had both AML‐M1 and non‐small‐cell lung cancer. These results are supported by...

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The provides facile practical synthesis pyrrolo[2,1-a]isoquinolines. A number pyrrolo[2,1-a]isoquinolines were synthesized moderate to high yields (up 97%).

Abstract Chiral spiro diphosphines (SDP) are efficient ligands for the Pd‐catalyzed asymmetric allylic alkylation of 1,3‐diphenyl‐2‐propenyl acetate with dimethyl malonate and related nucleophiles. The newly synthesized ligand DMM‐SDP ( 1e ) 3,5‐dimethyl‐4‐methoxy groups on P ‐phenyl rings phosphine shows highest enantioselectivity (up to 99.1% ee). Diethylzinc as a base is critical obtaining high in using β‐dicarbonyl structure catalyst [PdCl 2 (( S )‐SDP)] was determined by single crystal...

Summary Interleukin 6 (IL‐6) influences the growth and survival of multiple myeloma (MM) cells via activation signalling cascades. Although sphingosine kinase (SPHK) is known to play important roles in regulation cell proliferation apoptosis, role SPHK IL‐6 pathology MM remains unclear. This study found that activated cells, which mediates suppressive effects on apoptosis. Both lines primary constitutively expressed SPHK, treatment with resulted a concentration‐dependent manner. Specific...

Enantioselective Friedel–Crafts alkylation/cyclization of the indole carbocyclic ring with isatylidene malononitriles was performed using a new bifunctional catalyst.

Abstract An efficient and divergent one‐pot synthesis of substituted 2 H ‐pyrans, 4 ‐pyrans pyridin‐2(1 )‐ones from β‐oxo amides based on the selection reaction conditions is reported. Mediated by N,N,N′,N′ ‐tetramethylchloroformamidinium chloride, underwent intermolecular cyclizations in presence triethylamine at room temperature to give high yields, which could be converted into sodium hydroxide ethanol temperature, or under reflux.