A5041061514- Bone health and osteoporosis research
- Hip and Femur Fractures
- Bone health and treatments
- Bone fractures and treatments
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Elbow and Forearm Trauma Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Orthopedic Surgery and Rehabilitation
- Natural Compound Pharmacology Studies
- Hip disorders and treatments
- Estrogen and related hormone effects
- Medicinal Plant Extracts Effects
- COVID-19 and healthcare impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Surgical Sutures and Adhesives
- Menopause: Health Impacts and Treatments
- Nutrition and Health in Aging
- Medical and Biological Ozone Research
- Telemedicine and Telehealth Implementation
- Biomarkers in Disease Mechanisms
- Facial Rejuvenation and Surgery Techniques
- Pregnancy and Medication Impact
Georgetown University
2014-2024
MedStar Georgetown University Hospital
2014-2024
Georgetown University Medical Center
2008-2024
Pennsylvania State University
2024
University of Arizona
2016
Columbia University
2016
Johns Hopkins University
2016
University of California, San Francisco
2016
Mayo Clinic in Florida
2016
New York University
2016
Osteoporosis is the most common metabolic bone disease in USA and world. It a subclinical condition until complicated by fracture(s). These fractures place an enormous medical personal burden on individuals who suffer from them take significant economic toll. Any new fracture adult aged 50 years or older signifies imminent elevated risk for subsequent fractures, particularly year following initial fracture. What patient perceives as unfortunate accident may be seen sentinel event indicative...
Denosumab and zoledronic acid (ZOL) are parenteral treatments for patients with osteoporosis.The objective of the study was to compare effect transitioning from oral bisphosphonates denosumab or ZOL on bone mineral density (BMD) turnover.This an international, multicenter, randomized, double-blind trial.A total 643 postmenopausal women osteoporosis previously treated participated in study.Subjects were randomized 1:1 sc 60 mg every 6 months plus iv placebo once 5 12 months.Changes BMD...
ABSTRACT In the United States, osteoporosis affects over 10 million adults, has high societal costs ($22 billion in 2008), and is currently being underdiagnosed undertreated. Given an aging population, this burden expected to rise. We projected fracture US women by modeling demographic shift as well potential policy changes. With anticipated population growth, annual fractures are increase from 1.9 3.2 (68%), 2018 2040, with related rising $57 $95 billion. Policy‐driven expansion of case...
Interstitial cystitis (IC) is a relatively uncommon and enigmatic disorder characterized by pain in the bladder pelvic region, typically accompanied urinary urgency frequency. Fibromyalgia more common disorder, with prominent symptoms being diffuse musculoskeletal fatigue, it has been well established that there substantial clinical overlap between fibromyalgia chronic fatigue syndrome (CFS). Although genitourinary predominate IC respectively, both disorders share number of features,...
The International Osteoporosis Foundation (IOF) Capture the Fracture® Campaign with Fragility Fracture Network (FFN) and National (NOF) has developed eleven patient-level key performance indicators (KPIs) for fracture liaison services (FLSs) to guide quality improvement.Fracture Liaison Services are recommended worldwide reduce risk after a sentinel fracture. Given not every FLS is automatically effective, IOF working group implemented Best Practice Framework assess organisational components...
Calcium is the dominant mineral present in bone and a shortfall nutrient American diet. Supplements have been recommended for persons who do not consume adequate calcium from their diet as standard strategy prevention of osteoporosis related fractures. Whether with or without vitamin D supplementation beneficial detrimental to vascular health known.The National Osteoporosis Foundation Society Preventive Cardiology convened an expert panel evaluate effects dietary supplemental on...
Abstract Summary In a characterization of treatment rates and healthcare costs among patients with an osteoporotic-related fragility fracture overall by site care, were high low. Purpose Osteoporotic fractures can be debilitating, even fatal, older adults. The cost osteoporosis related is projected to increase more than $25 billion 2025. objective this analysis characterize disease-related osteoporotic diagnosis. Methods retrospective analysis, individuals identified in the Merative...
Bone weakening can be affected by agents other than bone mineral density (BMD). Increased marrow fat may have a direct link to loss. This pilot study analyzes the relationship between and BMD in subjects with normal structurally weakened vertebrae.Twenty-six underwent both dual-energy X-ray absorptiometry proton MR spectroscopy of 71 lumbar vertebrae. Fifteen had normal-appearing vertebrae on MRI, 11 signs weakening.We found that high did not consistently equate low BMD. indicate nearly as...
The effects of COVID-19 have the potential to impact on management chronic diseases including osteoporosis. A global survey has demonstrated that these impacts include an increase in telemedicine consultations, delays DXA scanning, interruptions supply medications and reductions parenteral medication delivery. pandemic had profound health population both directly, via sequelae infection, indirectly, relative neglect disease management. Together International Osteoporosis Foundation National...
Objective: The objective of this double-blind, randomised, placebo-controlled, multicentre clinical study was to demonstrate the non-inferiority and safety hypericum extract STW3-VI in a once-daily dosage regime treatment moderate depression. During 6-week phase, course depression documented by use HAMD (items 1-17), von Zerssen's Adjective Mood Scale (BfS) CGI scales. primary 3-arm design (900 mg) SSRI citalopram (20 superiority over placebo. Methods: Outpatients (N = 388) suffering from...
Abstract Background Osteoporotic-related fractures represent an increasing burden to patients, health care systems and society. Aims This study estimated cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) compared relevant alternative strategies in US men women aged 50 80 years at very high fracture risk (bone mineral density T-score ≤ − 2.5 a recent fracture). Methods A lifetime Markov-based microsimulation model was used estimate healthcare...
Objective: The objective of this double-blind, multi-center clinical study was to demonstrate the non-inferiority hypericum extract versus sertraline in treatment moderate depression. Methods: A total 241 patients with a diagnosis depressive disorder (according ICD-10 criteria) were randomized either 50 mg or 612 (hypericum group n = 123; 118). According protocol, 200 treated for at least 12 weeks (n 102 extract; 98 sertraline); 81 and 80 after week an additional weeks. Thus, most period 6...
Abaloparatide (ABL) significantly increases bone mineral density in men with osteoporosis similar to what was reported postmenopausal women osteoporosis. The cost effectiveness of sequential treatment ABL followed by alendronate (ALN) at high fracture risk compared relevant alternative treatments. A Markov-based microsimulation model based on a lifetime US healthcare decision maker perspective developed evaluate the (expressed US$2021) per quality-adjusted life-years (QALYs) gained ABL/ALN....
Abstract Osteoporosis in men is an underappreciated public health issue, accounting for approximately 30% of the societal burden osteoporosis. Although prevalence osteoporosis lower, fracture-related morbidity and mortality rates exceed those women. Abaloparatide a synthetic, 34-amino acid peptide with homology to human parathyroid hormone-related protein (PTHrP), which favors bone formation by selective activation PTH receptor type 1. In Treatment Men With (ATOM; NCT03512262) trial, 228...