A5075749514- Lipoproteins and Cardiovascular Health
- SARS-CoV-2 and COVID-19 Research
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- RNA and protein synthesis mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- vaccines and immunoinformatics approaches
- Hemophilia Treatment and Research
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Click Chemistry and Applications
- Molecular Communication and Nanonetworks
- Viral Infections and Immunology Research
- Cancer-related Molecular Pathways
- Genetic Syndromes and Imprinting
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Virus-based gene therapy research
Umm al-Qura University
2016-2025
King Khalid University
2024
Ministry of Health
2020-2022
King Abdulaziz City for Science and Technology
2022
Bircham International University
2019
King Saud University
2011-2014
A novel electroactive shape memory polymer nanocomposite of epoxidized linseed oil plasticized polylactic acid and multi-walled carbon nanotubes (MWCNTs) was prepared by a combination solution blending, solvent cast technique, hydraulic hot press moulding. In this study, (PLA) first (ELO) in order to overcome the major limitations PLA, such as high brittleness, low toughness, tensile elongation. Then, MWCNTs were incorporated into ELO PLA matrix at three different loadings (2, 3 5 wt. %),...
Alzheimer’s disease is one of the main causes dementia among elderly individuals and leads to neurodegeneration different areas brain, resulting in memory impairments loss cognitive functions. Recently, a rare variant that associated with 3-fold higher risk onset has been found. The discovered missense mutation loop region exon 2 Trem2 (rs75932628-T, Arg47His). aim this study was investigate evidence for potential structural functional significance gene (Arg47His) through molecular dynamics...
The COVID-19 pandemic that emerged in Wuhan city of China December 2019 has adversely impacted the health and economy, society, other significant spheres human environment. severely economic activities, especially industrial production, transportation, tourism, hoteling industries. present study analyses impact varying severity lockdowns activities during various phases on water quality Yamuna river parameters like pH values, biological oxygen demand, chemical dissolved oxygen, total...
Autosomal recessive ataxias are heterogeneous group of disorders characterized by cerebellar atrophy and peripheral sensorimotor neuropathy. Molecular characterization this identified a number genes contributing to these overlapping phenotypes. Ataxia with oculomotor apraxia type 2 (AOA2) is an autosomal form ataxia caused mutations in the SETX gene. We report on consanguineous family inheritance clinical characteristics AOA2, no mapped AOA locus chromosome 17p12-p13. Sequencing all refined...
Single amino acid substitutions in the globin chain are most common forms of genetic variations that produce hemoglobinopathies--the widespread inherited disorders worldwide. Several hemoglobinopathies result from homozygosity or compound heterozygosity to beta-globin (HBB) gene mutations, such as producing sickle cell hemoglobin (HbS), HbC, HbD and HbE. these mutations deleterious moderate severe hemolytic anemia, with associated complications, requiring lifelong care management. Even...
An efficient atom-economical synthetic protocol to access new imidazole-based N -phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized provide a series of N-phenylbenzamide in short time (2–4 h) with an 80–85% yield. The cytotoxic evaluation revealed that 4e and 4f exhibited good activity, IC 50 values between 7.5 11.1 μM against the tested cancer cell lines. Computational studies interesting insights: docking active (4e 4f) showed higher affinity toward...
Although rice resistance plays an important role in controlling the brown planthopper (BPH), Nilaparvata lugens, not all varieties have same level of protection against BPH infestation. Understanding molecular interactions defense response is tool to help reveal unexplained processes that underlie BPH. A proteomics approach was used explore how wild type IR64 and near-isogenic mutants with gain loss respond during total 65 proteins were found markedly altered Fifty-two associated 11...
Abstract Familial hypercholesterolemia (FH) is an autosomal dominant disease predominantly caused by a mutation in the low-density lipoprotein receptor ( LDLR ) gene. Here, we describe two severely affected FH patients who were resistant to statin therapy and managed on apheresis program. We identified novel duplication variant c.1332dup, p.(D445*) at exon 9 known silent c.1413A>G, p.(=), rs5930, NM_001195798.1 10 of gene both patients.
<strong>Background:</strong> Familial hypercholesterolemia (FH) is an autosomal dominant inherited genetic disorder and results in the development of coronary artery disease (CAD). Clinical diagnosis homozygous HH patients usually straightforward because persistent can produce xanthoma corneal arcus. However, may also be misdiagnosed as skin lesions could therefore mistreated. The aim this case study report to highlight plight with FH means raising awareness condition among dermatologists...
Internal ribosome entry site (IRES) sequences have become a valuable tool in the construction of gene transfer and therapeutic vectors for multi-cistronic expression from single mRNA transcript. The optimal conditions effective use this sequence to construct functional vector are not precisely defined but it is generally assumed that internal dependent second such as cassette less efficient than cap-dependent first gene. Mainly tailoring inter-cistronic significantly enhances IRES...
Familial hypercholesterolemia (FH) is most commonly caused by mutations in the LDL receptor (LDLR), which responsible for hepatic clearance of from blood circulation. We described a severely affected FH proband and their first-degree relatives; was resistant to statin therapy managed on an apheresis program. In order find causative genetic variant this family, direct exon sequencing LDLR, APOB PCSK9 genes performed. identified compound heterozygous mutation with missense p.(W577C) frameshift...
Choroid plexus papilloma (CPP) is a rare benign tumor of the central nervous system that usually confined to cerebral ventricles. According World Health Organization, CPP corresponds grade I atypical (a-CPP); however, it can become more aggressive and reach II, which rarely undergo malignant transformation into choroid carcinoma (grade III). To best our knowledge, identification these tumors mutations by next generation DNA sequencing (NGS) has not been yet reported. In present study, NGS...
Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine in purines.
Heat shock proteins are ubiquitous, induced under a number of environmental and metabolic stresses, with highly conserved DNA sequences among mammalian species. Camelus dromedaries (the Arabian camel) domesticated semi-desert environments, is well adapted to tolerate survive against severe drought high temperatures for extended periods. This the first report molecular cloning characterization full length cDNA encoding putative stress-induced heat HSPA6 protein (also called HSP70B′) from...
A targeted customized sequencing of genes implicated in autosomal recessive polycystic kidney disease (ARPKD) phenotype was performed to identify candidate variants using the Ion torrent PGM next-generation sequencing. The results identified four potential pathogenic PKHD1 gene [c.4870C > T, p.(Arg1624Trp), c.5725C p.(Arg1909Trp), c.1736C p.(Thr579Met) and c.10628T G, p.(Leu3543Trp)] among 12 out 18 samples. However, one variant c.4870C p.(Arg1624Trp) common eight patients. Some patient...