A5042077126- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological and metabolic disorders
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Nuclear Receptors and Signaling
- Traumatic Brain Injury Research
- Diet and metabolism studies
- Folate and B Vitamins Research
- Transcranial Magnetic Stimulation Studies
- Air Quality and Health Impacts
- Ginkgo biloba and Cashew Applications
- Catalytic Processes in Materials Science
- Ultrasound and Hyperthermia Applications
- Stroke Rehabilitation and Recovery
- Vitamin K Research Studies
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrospinal fluid and hydrocephalus
- Noise Effects and Management
- Climate Change and Health Impacts
- Neurobiology of Language and Bilingualism
Yonsei University
2009-2025
Korea University
2024
Gangnam Severance Hospital
2024
Wonju Severance Christian Hospital
2024
Samsung (South Korea)
2023
Inje University Busan Paik Hospital
2021
Montreal Neurological Institute and Hospital
2019
McGill University
2019
Severance Hospital
2018
OBJECTIVE Focused ultrasound (FUS)–mediated blood-brain barrier (BBB) opening is safe and potentially beneficial in patients with Alzheimer’s disease (AD) for the removal of amyloid-beta (Aβ) plaques. However, optimal BBB intervals number treatment sessions clinical improvement remain undefined. Therefore, aim this study was to evaluate safety benefits repeated more extensive alone. METHODS In open-label prospective study, 6 AD were enrolled from June 2022 July 2023. FUS-mediated performed...
Abstract Objective Although chronic exposure to air pollution is associated with an increased risk of dementia in normal elderlies, the effect on rates cognitive decline Alzheimer's disease (AD) has not been elucidated. Methods In this longitudinal study, a total 269 patients mild impairment or early due AD evidence brain β‐amyloid deposition were followed‐up for mean period 4 years. Five‐year normalized hourly cumulative value each pollutant, such as carbon monoxide (CO), nitrogen dioxide...
Although most cases of logopenic variant primary progressive aphasia (lvPPA) are caused by Alzheimer's disease (AD), Lewy body (LBD) has also been reported. We assessed brain perfusion, atrophy, dopamine transporter (DAT) uptake, and language function among patients with lvPPA based on beta-amyloid. Thirty-three 28 healthy controls (HCs) underwent MRI, 18F-florbetaben PET, early- late-phase DAT PET. All completed a test. General linear models were applied to investigate the association...
To investigate the independent and interaction effects of Alzheimer disease (AD) Lewy body (LBD) on cognition brain atrophy.We consecutively recruited 38 controls 108 patients with AD-related cognitive impairment (ADCI) and/or LBD-related (LBCI) from university-based dementia movement clinics. Diagnoses ADCI LBCI were supported by 18F-florbetaben PET 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane-PET, respectively. There controls, 26 pure (18 mild [MCI] 8 dementia), 28...
The correlates of motor parkinsonism in Alzheimer's disease (AD) remain controversial. effects nigrostriatal dopaminergic degeneration on and cognition biomarker-validated patients with AD were evaluated.This study recruited 116 who underwent dual-phase 18 F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography, F-florbetaben 3 T brain magnetic resonance imaging, Unified Parkinson's Disease Rating Scale (UPDRS) neuropsychological tests. mean cortical...
Abstract INTRODUCTION Although mixed pathologies are common in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), the effects of amyloid beta dopaminergic depletion on brain perfusion clinical symptoms have not been elucidated. METHODS In 99 cognitive impairment patients due to AD and/or DLB 32 controls, 18F‐florbetaben (FBB) dual‐phase dopamine transporter (DAT) positron emission tomography (PET) were performed measure FBB standardized uptake value ratio (SUVR), striatal DAT...
This study aimed to determine the pattern of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) related postmortem Lewy body disease (LBD) pathology in clinical Alzheimer (AD).FDG-PET scans were analyzed 62 autopsy-confirmed patients and 110 controls Alzheimer's Disease Neuroimaging Initiative. Based on neuropathologic evaluations Braak stage for neurofibrillary tangle, Consortium Establish a Registry AD score neuritic plaque, Lewy-related pathology, subjects classified into...
This study aimed to determine the neuropsychological differences between patients with early-stage Alzheimer's disease (AD) and dementia Lewy bodies (DLB) a Clinical Dementia Rating (CDR) score of ≤1.We examined 168 AD (126 CDR score=0.5, 42 score=1) 169 DLB (104 65 whose diagnoses were supported by 18F-flobetaben positron-emission tomography (PET) 18F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane PET. Neuropsychological test scores compared after controlling for age, sex,...
Abstract Nigrostriatal dopaminergic degeneration is a pathological hallmark of dementia with Lewy bodies (DLB). To identify the subregional dopamine transporter (DAT) uptake patterns that improve diagnostic accuracy DLB, we analyzed N-(3-[ 18 F] fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl)-nortropane (FP-CIT) PET in 51 patients 36 mild cognitive impairment body (MCI-LB), and 40 healthy controls (HCs). In addition to high affinity for DAT, FP-CIT show modest serotonin or norepinephrine...
Association of medial temporal lobe (MTL) metabolism with Alzheimer's disease (AD) and dementia Lewy bodies (DLB) has not been evaluated considering their mixed (MD).
Abstract Objective Although basal forebrain (BF) cholinergic degeneration and white matter hyperintensities (WMHs) are important in neurodegeneration Alzheimer's disease (AD) dementia with Lewy bodies (DLB), their relationships dopaminergic clinical manifestations remain unclear. Methods A total of 407 patients cognitive impairment meeting the diagnostic criteria for AD, DLB, or both (AD+DLB) were assessed. All participants underwent 3T MRI, dopamine transporter (DAT) positron emission...
To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in diagnosis clinical symptoms dementia with Lewy bodies (DLB), 55 DLB patients 49 controls underwent neuropsychological evaluation FDG-, DAT-, 18F-Florbetaben (FBB) PET. DAT- FDG-uptake FDG/DAT ratio were measured anterior posterior striatum. The first principal component (PC1) FDG subject residual profiles was identified for each subject. Receiver operating...
Abstract Introduction Lewy body–related pathology is commonly observed at autopsy in individuals with dementia, but vivo biomarkers for α‐synucleinopathy are lacking. Methods Baseline cerebrospinal fluid (CSF) biomarkers, polygenic risk score (PRS) Parkinson's disease (PRS‐PD) and Alzheimer's (PRS‐AD), longitudinal cognitive scores, magnetic resonance imaging were measured 217 participants from the Disease Neuroimaging Initiative. Linear mixed models used to find relationship of CSF PRS...
Coexisting Alzheimer's disease (AD) pathology is common in Parkinson's (PD). However, the implications of genetic risk scores (GRS) for AD have not been elucidated PD. In 413 de novo PD and 195 healthy controls from Progression Marker Initiative database, effects GRS (GRS-AD) (GRS-PD) on longitudinal CSF biomarkers clinical outcomes were explored. Higher GRS-PD lower baseline α-synuclein associated with an increased group, GRS-AD was correlated positively p-tau/Aβ negatively α-synuclein....
Abstract Background : Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is safe and potentially beneficial in patients with Alzheimer’s disease (AD) for the removal of amyloid plaques behavioral improvement. We aimed to evaluate safety, feasibility, potential benefits repeated extensive BBB opening. Methods In this open-label prospective study, six AD were enrolled at Severance Hospital Korea from July 2022 2023. FUS-mediated was performed three times 2-month intervals...
Parkinson disease (PD) shows degeneration of dopaminergic neurons in the substantia nigra and characteristic changes brain metabolism. However, how they correlated affect motor cognitive dysfunction PD has not yet been well elucidated.
Background: Small vessel disease (SVD) magnetic resonance imaging (MRI) markers including deep and periventricular white matter hyperintensities (PWMH), lacunes, microbleeds are frequently observed in Alzheimer’s (AD) Lewy body (LBD), but their implication has not been clearly elucidated. Objective: To investigate the of SVD MRI cognitively impaired patients with AD and/or LBD. Methods: We consecutively recruited 57 pure AD-related cognitive impairment (ADCI), 49 LBD-related (LBCI), 45 mixed...
Abstract Background Although mixed pathologies are common in Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB), effects of β‐amyloid dopaminergic depletion on brain perfusion clinical features have not been elucidated. Method In 99 patients cognitive impairment due to AD and/or DLB 32 control participants, 18 F‐Florbetaben (FBB) PET, dual‐phase dopamine transporter (DAT) MRI were performed measure standardized uptake value ratio (SUVR), the ventral striatum, caudate, putamen,...