A5043611567- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Clinical practice guidelines implementation
- Neuroendocrine Tumor Research Advances
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Research
- Stroke Rehabilitation and Recovery
- Adrenal and Paraganglionic Tumors
- Atrial Fibrillation Management and Outcomes
- Meta-analysis and systematic reviews
- Acute Ischemic Stroke Management
- Mobile Health and mHealth Applications
- Venous Thromboembolism Diagnosis and Management
- Diabetes Management and Education
- Artificial Intelligence in Healthcare
- Healthcare cost, quality, practices
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Risk Factors
- Digital Mental Health Interventions
- Myasthenia Gravis and Thymoma
- Musculoskeletal pain and rehabilitation
- Pressure Ulcer Prevention and Management
- Digital Imaging in Medicine
- Health Policy Implementation Science
- Health Sciences Research and Education
Healthcare Improvement Scotland
2025
Duke University
2023
Palomar Health
2020
Premier Research Group
2016-2020
Clinical Research Institute
2018
University of Cincinnati Medical Center
2018
Scottish Intercollegiate Guidelines Network
2005-2017
KCI (United States)
2014
International Severity Information Systems (United States)
2005-2010
Indiana University School of Medicine
2009
Conventional surgery and radiotherapy for acromegaly have limitations. There are few data on the use of somatostatin analog octreotide (Oct) as primary medical therapy. An open prospective study 27 patients with newly diagnosed was conducted in nine endocrine centers United Kingdom. Twenty had macroadenomas, 7 microadenomas. For first 24 wk (phase 1), received sc Oct an initial dose 100 μg, 3 times daily, increased to 200 μg three daily after 4 13 whose mean serum GH remained greater than 5...
Artificial intelligence (AI) has been defined by the High-Level Expert Group on AI of European Commission as "systems that display intelligent behaviour analysing their environment and taking actions-with some degree autonomy-to achieve specific goals." potential to support guideline planning, development adaptation, reporting, implementation, impact evaluation, certification, appraisal recommendations, which we will refer "guideline enterprise." Considering this potential, well lack...
OBJECTIVE To assess the results of transsphenoidal pituitary surgery in patients with Cushing's disease over a period 18 years, and to determine if there are factors which will predict outcome. PATIENTS Sixty‐nine sequential treated surgically by single surgeon Newcastle upon Tyne between 1980 1997 were identified data from 61 these have been analysed. DESIGN Retrospective analysis outcome measures. MAIN OUTCOME MEASURES Patients divided into three groups (remission, failure relapse)...
Phaeochromocytoma crisis is a life-threatening emergency that may be undiagnosed because of its numerous, nonspecific manifestations. We analysed, retrospectively, the presentation, management and outcome patients who were admitted to our institution with phaeochromocytoma crises over 5-year period.Five (two males, three females; mean age 34.6 years, range 19-51 years) presented as emergencies requiring intensive care, multiple non-specific manifestations previously pheochromocytoma,...
Abstract OBJECTIVE. To prospectively monitor occupational therapy activities and intervention techniques used during inpatient stroke rehabilitation in order to provide a description of current clinical practice. METHODS. Data were collected from 954 clients with receiving six U.S. hospitals. Descriptive statistics summarized frequency, intensity, duration sessions; proportion time spent 16 therapeutic activities; those that included any 31 interventions. RESULTS. Clients received on average...
To design and facilitate implementation of practice-based evidence changes associated with decreases in pressure ulcer (PrU) development long-term-care (LTC) facilities promote these practices as part routine care.Pre/post observational study.Frail older adult residents 11 US LTC facilities.Project facilitators assisted frontline multidisciplinary teams (certified nurse aides [CNAs], nurses, dietitians/dietary aides) to develop streamlined standardized CNA documentation weekly reports...
Clinical practice guidelines (CPGs) can play a crucial role in achieving better and more cost-efficient health care. This requires training care providers CPG development. study presents results of design-based research on program based the learning theory problem-based learning, following underlying principles active, authentic, collaborative, blended learning. The CoCoCare aims to equip neurology residents with insight development (including cost aspects) understanding how apply CPGs...
Preliminary studies have demonstrated that some pituitary adenomas secrete immunoreactive interleukin-6 (irIL-6) when cultured in vitro. We extended these by investigating 100 of different types measuring and bioactive IL-6. Tumors were either as explants without fetal calf serum or dispersed cells with 10% total serum. Fifty-three the (53%) cultures found to release irIL-6 44 examined, 32 (72.7%) secreted In 61 explant cultures, 30 released IL-6, indicating autonomous secretion. The amount...
Free accessAbstractFirst published online July 2010S109– Rationalized perioperative antibiotic prophylaxis through incorporation of Scottish Intercollegiate Guideline Network (SIGN) guidelines with local practiceWendy L. Craig, MPH, Presenter, Roberta James, PhD, and Terry O'Kelly, MDVolume 143, Issue 1_supplhttps://doi.org/10.1016/j.otohns.2010.04.231
Summary Background American Indian (AI) youth are at high risk for type 2 diabetes. Objectives To partner with Eastern Band of Cherokee Indians and Navajo Nation to develop a culturally sensitive behavioural intervention (Tribal Turning Point; TTP) assess feasibility in an 8‐month randomized pilot study. Methods We enrolled 62 overweight/obese AI children (7–10 years) who participated ≥1 parent/primary caregiver. Intervention participants ( n = 29) attended 12 group classes five individual...
Carbohydrate tolerance and serum lipids were studied in 14 patients with acromegaly before response to treatment high dose somatostatin analogue (octreotide) over a 14‐week period. Patients assessed respect growth hormone (GH) profile, IGF 1 , HbA fasting lipids, the GH, glucose, insulin standard 75 g oral glucose test (OGTT) during therapy. Prior mean levels 11.7 ± 2.8 (± SE) mU l −1 OGTT of 49.8 10.8 . Twelve responded octreotide reduction 24‐h GH (32.9 9.3 4.3 0.9 ), suppression at 60 min...
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The Project on a Framework for Rating Evidence in Public Health (PRECEPT) was initiated and is being funded by the European Centre Disease Prevention Control (ECDC) to define methodology evaluating grading evidence strength of recommendations field public health, with emphasis infectious disease epidemiology, prevention control. One first steps review existing quality appraisal tools (QATs) individual research studies various designs relevant this area, using question-based approach. Through...
Decisions in public health should be based on the best available evidence, reviewed and appraised using a rigorous transparent methodology. The Project Framework for Rating Evidence Public Health (PRECEPT) defined methodology evaluating grading evidence infectious disease epidemiology, prevention control that takes different domains question types into consideration. rates four domains: burden, risk factors, diagnostics intervention. framework guiding it has steps going from overarching...
Introduction To investigate the impact of digital Livongo Diabetes Prevention Program (DPP) on weight at 12 months, understand participants’ self-monitoring behaviors associated with greater loss, and evaluate coaching interactions more frequent behaviors. Research design methods A retrospective analysis was performed using data from 2037 participants enrolled in DPP who completed lesson 1 recorded a starting during 2016–2017. Self-monitoring behaviors, including weigh-ins, food logging,...
Background Technology is rapidly advancing our understanding of how people with diabetes mellitus experience stress. Objective The aim this study was to explore the relationship between stress and sequelae within a unique data set composed adults enrolled in digital management program, Livongo, order inform intervention product development. Methods Participants included 3263 under age 65 who were diagnosed had access Livongo through their employer June 2015 August 2018. Data collected at...