İrem Deniz Derman

ORCID: 0000-0001-9824-9071
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About
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Research Areas
  • 3D Printing in Biomedical Research
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Soft Robotics and Applications
  • Tendon Structure and Treatment
  • Collagen: Extraction and Characterization
  • Additive Manufacturing and 3D Printing Technologies
  • Augmented Reality Applications
  • Wound Healing and Treatments
  • Nerve injury and regeneration
  • Tissue Engineering and Regenerative Medicine
  • Respiratory Support and Mechanisms
  • Cell Image Analysis Techniques
  • Hair Growth and Disorders
  • Neonatal Respiratory Health Research
  • Respiratory viral infections research
  • Single-cell and spatial transcriptomics
  • Surgical Simulation and Training
  • Silk-based biomaterials and applications
  • Electrospun Nanofibers in Biomedical Applications
  • Planarian Biology and Electrostimulation
  • Tracheal and airway disorders
  • Dermatologic Treatments and Research
  • Lysosomal Storage Disorders Research
  • Olfactory and Sensory Function Studies
  • Cancer Cells and Metastasis

Pennsylvania State University
2023-2024

Park University
2023

Millennium Engineering and Integration (United States)
2023

Istanbul Technical University
2020

Progenitor human nasal epithelial cells (hNECs) are an essential cell source for the reconstruction of respiratory pseudostratified columnar epithelium composed multiple types in context infection studies and disease modeling. Hitherto, manual seeding has been dominant method creating tissue models through biofabrication. However, this approach limitations terms achieving intricate three-dimensional (3D) structure natural epithelium. 3D bioprinting utilized to reconstruct various models,...

10.1088/1758-5090/aced23 article EN cc-by Biofabrication 2023-08-03

Craniomaxillofacial (CMF) reconstruction is a challenging clinical dilemma. It often necessitates skin replacement in the form of autologous graft or flap surgery, which differ from one another based on hypodermal/dermal content. Unfortunately, both approaches are plagued by scarring, poor cosmesis, inadequate restoration native anatomy and hair, alopecia, donor site morbidity, potential for failure. Therefore, new reconstructive warranted, tissue engineered represents an exciting...

10.1016/j.bioactmat.2023.10.034 article EN cc-by-nc-nd Bioactive Materials 2023-11-09

Gaucher disease (GD), the most prevalent lysosomal disorder, is caused byGBA1gene mutations, leading to deficiency of glucocerebrosidase, and accumulation glycosphingolipids in cells mononuclear phagocyte system. While skeletal diseases are cause morbidity reduced quality life GD, pathophysiology bone involvement not yet fully understood, partly due lack relevant human model systems. In this work, we present first 3D GD using aspiration-assisted freeform bioprinting, which enables a platform...

10.1088/1758-5090/acf95a article EN cc-by Biofabrication 2023-09-13

Craniomaxillofacial (CMF) reconstruction is a challenging clinical dilemma. It often necessitates skin replacement in the form of autologous graft or flap surgery, which differ from one another based on hypodermal/dermal content. Unfortunately, both approaches are plagued by scarring, poor cosmesis, inadequate restoration native anatomy and hair, alopecia, donor site morbidity, potential for failure. Therefore, new reconstructive warranted, tissue engineered represents an exciting...

10.1101/2023.10.03.560695 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-10-05

Abstract In this study, we developed a three-dimensionally (3D) printed lung model that faithfully recapitulates the intricate environment. This 3D incorporated alveolar and vascular components allow for comprehensive exploration of physiology responses to infection in vitro . particular, investigated role ventilation on formation epithelial layer its response viral infections. regard, subjected our printed, perfused continuous respiratory cycle at air-liquid interface (ALI) up 10 days...

10.1101/2023.09.24.559194 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-09-24

Abstract Precise investigation of the temperature and duration for collagen denaturation is critical a number applications, such as adjustment during laser-assisted tissue welding or collagen-based repair products (films, implants, cross-linkers) preparation procedures. The result studies can serve guideline to mitigate potential side effects while maintaining functionality collagen. Though variety temperatures have been reported, there has not systematic study report temperature-dependent...

10.1101/682401 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2019-06-26

Human nasal epithelial cells (hNECs) are an essential cell source for the reconstruction of respiratory pseudostratified columnar epithelium composed multiple types in context infection studies and disease modeling. Hitherto, manual seeding has been dominant method creating tissue models. However, approach is slow, low-throughput limitations terms achieving intricate 3D structure natural a uniform manner. Bioprinting utilized to reconstruct various models, such as cutaneous, intestinal,...

10.1101/2023.03.29.534723 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2023-03-30

We present a miniaturized actuator for volumetric tissue imaging. The device consists of hydraulically actuated accordion-like part axial scanning (focus adjustment), and an electromagnetically 2D scanner lateral scanning. is manufactured using selective laser sintering, allowing very low cost rapid production. demonstrate 3D capability through observing the scan pattern at different locations with CMOS camera, multi-layered phantom. further investigate reliability scanner, as well...

10.1117/12.2550250 article EN 2020-02-28
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