Oxidative modification of LDL is an early pathological event in the development atherosclerosis. Oxidation events such as malondialdehyde (MDA) formation may produce specific, immunogenic epitopes. Indeed, antibodies to MDA-derived epitopes are widely used atherosclerosis research and have been demonstrated enable cardiovascular imaging. In this study, we engineered a transgenic zebrafish with temperature-inducible expression EGFP-labeled single-chain human monoclonal antibody, IK17, which...

Endonasal dacryocystorhinostomy (DCR) is a well-established treatment method in patients with nasolacrimal duct obstruction. However, there are few reports about the overall management of failed endonasal DCR. We investigated causes and strategies DCR.This retrospective review included 61 (61 eyes) who had undergone revision surgery by same surgeon after DCR between January 2008 December 2012. The appropriate was determined analysis etiology failure fluorescein dye disappearance test, nasal...

At present there are conflicting results from studies investigating the role of corticosteroids in inhibiting airway remodeling asthma. We have used a mouse model to determine whether administration prevents development allergen-induced structural features remodeling. Mice treated with were subjected repetitive ovalbumin (OVA) challenge for 3 mo, at which time levels peribronchial fibrosis and thickness smooth muscle layer assessed by immunohistology, transforming growth factor (TGF)-beta1...

Objective The aim of this study was to evaluate the prognostic value squamous cell carcinoma antigen (SCC-Ag) and optimal cut-off for predicting recurrence in cervical patients with complete remission after primary treatment. Methods We reviewed records 783 cancer who underwent therapy showed at our institution between January 2000 April 2014. A receiver operating characteristic curve used determine SCC-Ag threshold predict recurrence. Cox regression model disease free survival assess...

Cholesterol-fed zebrafish is an emerging animal model to study metabolic, oxidative, and inflammatory vascular processes relevant pathogenesis of human atherosclerosis. Zebrafish fed a high-cholesterol diet (HCD) develop hypercholesterolemia are characterized by profound lipoprotein oxidation lipid accumulation. Using optically translucent larvae has the advantage monitoring pathology assessing efficacy drug candidates in live animals. Thus, we investigated whether simvastatin ezetimibe,...

To investigate the causes of lower eyelid retraction and evaluate outcomes various surgical procedures.We conducted a retrospective medical record review patients who underwent surgery performed by single surgeon at Kim's Eye Hospital between 2006 2013. We investigated retraction, clinical history, characteristics, treatment, outcomes. Preoperative postoperative margin reflex distance 2 inferior scleral show were measured for each eyelid. Success was defined as positive elevation decrease in...

We evaluated the role of optic nerve sheath diameter (ONSD) using brain computed tomography (CT) in predicting neurological outcomes patients with subarachnoid hemorrhage (SAH). This was a retrospective, multicenter, observational study adult SAH admitted between January 2012 and June 2017. Initial CT performed within 12 h from onset SAH, follow-up 24 treatment ruptured aneurysm. Primary outcome status at 6-month assessed Glasgow Outcome Scale (GOS, 1 to 5). Among 223 patients, 202 (90.6%)...

To evaluate prognostic factors affecting silicone tube intubation outcomes in Asian patients with lacrimal drainage system stenosis.A retrospective review was conducted on the medical records of 822 (1,118 eyes) who had undergone to treat stenosis between January 2011 and December 2012. Patients were divided into two groups: a success group failure group. Success defined as disappearance epiphora symptoms, normalization tear meniscus height, easy passage fluid without resistance...

This study aimed to analyze the common causes of epiphora in Korean patients and their response subsequent management. We retrospectively analyzed medical records 180 who visited Kim's Eye Hospital for between December 2017 January 2019. included 320 eyes patients. In patients, most etiology was reflex tearing due dry eye syndrome, which occurred 167 (52.19%). The other etiologies anatomical abnormality (68 eyes, 21.25%), multifactorial (60 18.75%), functional (14 4.38%), ocular surface...

Purpose: The objective of this study was to compare the surgical outcomes between interrupted and continuous buried suture methods in double eyelid blepharoplasty Koreans. Methods: Medical records 204 patients (392 eyes) who underwent operation by method were followed up for at least more than 3 months reviewed. Patients divided into 2 groups according method; an group (88 patients) a (116 patients). Results: rate loss formed is 19.3 % (17 88 8.6 (10 116 (P = 0.026). One patient experienced...

Objective The aim of this study is to assess the effectiveness oral progestin treatment in women diagnosed with complex atypical hyperplasia (CAH) or grade 1 endometrial cancer (G1EC), who desire preserve their fertility, as alternative a hysterectomy. Methods We reviewed medical records younger than 45 years old that had been CAH G1EC, expressed fertility using at our institution. Women without evidence myometrial invasion on pelvic magnetic resonance imaging scans were included. period was...

To assess the ophthalmologic complications after oculofacial plastic and esthetic surgeries, including their incidence management.A retrospective study was performed on 110 patients who presented with ocular followed by surgeries from January 2014 to December 2015. The management of each surgery or procedure were analyzed.For lower eyelid blepharoplasty, common chemosis ectropion. There also a case canalicular laceration. Exposure keratitis corneal abrasion most upper blepharoplasty....

Purpose: To evaluate the surgical outcome between Quickert suture and with modified lateral tarsal strip in involutional lower eyelid entropion. Methods: A retrospective study was performed on 76 patients (94 eyes) who had undergone (Group 1) 38 (44 2) for correction of entropion from January 2011 to December 2013. Results: In Group 1, recurrence rate is 25.5% (24 mean duration 11.9 months 1. For recurrence, 50% (12 eyes), 37.5% (9 12.5% (3 eyes). 2, 9.1% (4 retractor reinsertion (2 25% (1...

To analyze the clinical features of benign essential blepharospasm in Korean patients.Patients diagnosed with Kim's Eye Hospital from November 2014 to December 2016 were evaluated using a examination and questionnaire. The questionnaire reviewed personal medical history, demographic factors, risk factors for development, relieving aggravating factors.Of 101 patients enrolled, 78 (77.2%) women. mean age was 64.9 years old. Hypertension most common disorder (42.6%), followed by diabetes...

To compare the effect of intravitreal ranibizumab injections for treatment neovascular age-related macular degeneration between phakic and pseudophakic eyes.We retrospectively reviewed medical records 110 patients with receiving therapy categorized them into 2 subgroups: group (75 eyes) (45 eyes). For all patients, initial three loading were performed by month, reinjection was as needed. Main outcome measures included best-corrected visual acuity central thickness assessed optical coherence...

To evaluate the effect of posterior vitreomacular adhesion (VMA), documented by optical coherence tomography, on outcome anti-vascular endothelial growth factor treatment polypoidal choroidal vasculopathy.Medical records 102 patients (104 eyes) with vasculopathy were retrospectively reviewed and categorized according to presence VMA into 2 subgroups: positive (+) group (23 negative (-) (81 eyes). Best-corrected visual acuity central macular thickness after antivascular compared between...

Abstract Blepharoplasty is the most frequently performed cosmetic surgical procedure in Asia. The epicanthal fold, which common Asians, characterized by a curved skin fold that partially hides caruncle and lacrimal lake. may cause weakening of esthetic appearance after blepharoplasty. It makes palpebral fissure height narrower length shorter horizontally. with epicanthoplasty can enhance appearance, but no gold standard technique has been established for epicanthoplasty. Surgeons choose...

대전 민들레안과 3 목적: Colvard와 ORBScanⅡ, Sirius 세 장비로 측정한 동공크기를 비교하고, 굴절교정수술 후 야간시력불편함과 동공크기의 상관관계를 비교하였다.대상과 방법: 전 Colvard, Sirius, ORBScanⅡ로 환자 100명 200안의 의무기록을 후향분석하였다.암순응 상태의 동공크기는 Sirius를, 명순응 ORBScanⅡ과 Sirius를 비교하였다.수술 3개월 야간시 력불편함 정도를 설문조사하여 동공크기와의 검사방법에 따라 비교하였다

To determine the relationship between distribution of adrenergic receptors in human eyelid and elevation after topically instilling 0.5% apraclonidine blepharoptosis patients.A total 26 blepharoptotic patients (30 eyelids) were included experimental study. Marginal reflex distance 1 was measured before topical instillation apraclonidine. Eyelids divided into 2 groups according to responses Patients who positively responded classified as group A those that negatively it B. Müller's muscle...

기존 무기체계 소프트웨어 품질 평가는 방위사업청의 개발단계별 산출물 점검표를 기반으로 한 동료검토를 통해 수행되었다. 점검표는 기술문서의 각 장/절에 대한 내용 유무 확인 수준으로 작성되어 모델링 데이터에 완전성, 일관성, 추적성과 같은 평가가 존재하지 않았다. 이로 인해 개발자 별로 작성 수준이 상이한 기술문서가 작성되었고, 동료검토에 의한 주관적이어서 일관성 있는 측정 및 수치화가 어려웠다. 그리고 산출물들에 검토가 자동화되지 못해 시간과 노력이 많이 소모되었다. 기존의 기술문서 평가 방법을 개선하기 위하여 구성 요소들을 표현하는 참조 모델 방안을 제안하고 정량적인 평가를 위해 메트릭 제시하였다. 또한 자동화된 위한 도구 개발 소개한다.

Purpose: To evaluate the long-term surgical success rate (>3 years) and contributing factors considering motor sensory criteria for patients with intermittent exotropia.Methods: Fifty-four who received surgery exotropia were followed-up a minimum of 3 years, including reoperation, retrospectively evaluated.The first procedure was unilateral recession resection in 50 bilateral lateral rectus 4 patients.Patients classified as achieving good, fair or poor outcome based on criteria.Success...

Lower eyelid orbital fat hyperplasia has not been described in young age patients.A fourteen-year-old girl, a 29-year-old man, and 42-year-old man had visited our hospital complaining of lower bulge. In computed tomography examination, there was excess tissue compared with the opposite side, but no mass lesion matched area bulge patients. The authors planned surgery for removal through conjunctival incision. Intraoperatively, real herniation septum. Septum continuity maintained thinning or...