A5056392028- Invertebrate Immune Response Mechanisms
- Animal Genetics and Reproduction
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Tryptophan and brain disorders
- Insect Utilization and Effects
- Neurobiology and Insect Physiology Research
- Diet and metabolism studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Insect and Arachnid Ecology and Behavior
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Biochemical Acid Research Studies
- Regulation of Appetite and Obesity
- Gut microbiota and health
- Viral Infectious Diseases and Gene Expression in Insects
Yueyang Changling Equipment Research Institute (China)
2024
Hunan Agricultural University
2023-2024
Yale University
2021-2023
Yale Cancer Center
2021-2023
Stockholm University
2013-2021
Abstract Background Innate immune responses are evolutionarily conserved processes that provide crucial protection against invading organisms. Gene activation by potent NF-κB transcription factors is essential both in mammals and Drosophila during infection stress challenges. If not strictly controlled, this defense system can activate autoimmune inflammatory reactions, with deleterious consequences for the organism. Negative regulation to prevent gene healthy organisms, presence of...
Abstract In many animals, germline development is initiated by proteins and RNAs that are expressed maternally. PIWI their associated small noncoding PIWI-interacting (piRNAs), which guide to target base-pairing, among the maternal components deposited into of Drosophila early embryo. Piwi has been extensively studied in adult ovary testis, where it required for transposon suppression, stem cell self-renewal, fertility. Consequently, loss using piwi-null alleles or knockdown from oogenesis...
PIWI genes are well known for their germline but not somatic functions. Here, we report the function of Drosophila piwi gene in adult gut, where intestinal stem cells (ISCs) produce enteroendocrine and enteroblasts that generate enterocytes. We show is expressed ISCs enteroblasts. Piwi deficiency reduced ISC number, compromised maintenance, induced apoptosis enterocytes, did affect proliferation its differentiation to cells. In addition, zygotic maternal mildly de-silenced several...
Gut immunity is regulated by intricate and dynamic mechanisms to ensure homeostasis despite a constantly changing microbial environment. Several regulatory factors have been described participate in feedback responses prevent aberrant immune activity. Little is, however, known about how transcriptional programs are directly tuned efficiently adapt host gut tissues the current microbiome. Here we show that POU/Oct gene nubbin (nub) encodes two transcription factor isoforms, Nub-PB Nub-PD,...
Highlights•Drosophila nubbin (nub) is expressed in adult midgut progenitor cells•The Nub-PB isoform drives differentiation and acts as a tumor suppressor•The Nub-PD maintains intestinal stem cell proliferation•Nub-PD regulate proliferation antagonisticallySummaryDrosophila POU/Oct transcription factors are required for many developmental processes, but their putative regulation of activity has not been investigated. Here, we show that Nubbin (Nub)/Pdm1, homologous to mammalian OCT1/POU2F1...
Abstract Background A number of cellular processes have evolved in metazoans that increase the proteome repertoire relation to genome, such as alternative splicing and translation recoding. Another process, translational stop codon readthrough (SCR), generates C-terminally extended protein isoforms many eukaryotes, including yeast, plants, insects, humans. While comparative genome analyses predicted existence programmed SCR species humans, experimental proof its functional consequences are...
Tryptophan (Trp) is an essential amino acid acting as a key nutrition factor regulating animal growth and development. But how Trp modulates food intake in pigs still not well known. Here, we investigated the effect of dietary supplementation with different levels on growing pigs. The data showed that standardized ileal digestibility (SID) to Lysine (Lys) ratio at both 0.18 0.20 significantly increased by activating expression orexigenic gene agouti-related peptide (AgRP) inhibiting...
Abstract Translational stop codon readthrough generates C-terminally extended protein isoforms. While evidence mounts of as a global phenomenon, proofs its functional consequences are scarce. We show that the mRNA for Drosophila POU/Oct transcription factor Drifter occurs at high rate and in spatiotemporal manner vivo , reaching above 50% prothoracic gland. Phylogenetic analyses suggested drifter is conserved among Dipterans, with C-terminal extensions harboring intrinsically disordered...
ABSTRACT In many animals, germline development is initiated by proteins and RNAs that are expressed maternally. PIWI their associated small noncoding P IWI- i nteracting (piRNAs), which guide to target base-pairing, among the maternal components deposited into of early embryo in Drosophila . Piwi has been extensively studied adult ovary testis, where it required for transposon suppression, stem cell self-renewal, fertility. Consequently, loss using piwi -null alleles or knockdown from...